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Researchers at Children’s Hospital of Philadelphia Highlight Role of Alternative Splicing in Chemotherapy Resistance

Researchers at Children’s Hospital of Philadelphia (CHOP) have elucidated the significant role that alternative splicing – a process whereby a single gene produces multiple proteins by rearranging its messenger RNA segments in different combinations – plays in resistance to chemotherapy in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). The study published today in the journal Cancer Research.

Two school-age girls wearing holiday lights and winter clothes, smiling and holding up peace signs
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Brighten up the season

This year, many children will spend the holidays in the hospital. Brighten the season for them and their families by creating a virtual toy drive—a fun and easy way to raise funds to buy gifts for kids in CHOP this holiday season.

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