Research Studies Finder

Use this finder to find a study or trial that is the right fit for your child. Also, filter results by phase — which are the specific steps researchers take throughout the trial to find answers, solutions and cures.

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Showing 1 - 10 of 344 results

SAR443579 in AML, B-ALL, or MDS

This study involves taking a study drug called SAR443579. The overall goal of this study is to find out if the study drug is safe and effective at treating adults and children with relapsed or refractory acute myeloid leukemia (R/R AML), high risk myelodysplastic syndrome (HR-MDS), or B-cell acute lymphoblastic leukemia (B-ALL). This is a first-in-human research study.

Phase: Phase I, Phase II

Actively recruiting: Yes

Category: Adults, Children

DCA Trial in PDC Deficiency

We are studying an investigational drug called sodium dichloroacetate (DCA). Investigational means that the study drug has not been approved by the US Food and Drug Administration (FDA) and that its use in this study is experimental. This a purpose of this research study is to determine whether DCA is a helpful treatment for patient with pyruvate dehydrogenase complex (PDC) deficiency (PDCD).

Phase: Phase III

Actively recruiting: No

Category: Children

The Charisma Study

We are currently enrolling adolescents ages 15-21 of South Asian ancestry, African American ancestry, and European American or "White" ancestry. This study is looking to better understand ancestry related differences in risks for developing cardiovascular disease and type 2 diabetes. The study involves 2 visits to the CHOP Main Hospital in Philadelphia, and participants will be compensated for their efforts.

Phase: N/A

Actively recruiting: No

Category: Adults, Children, Healthy Controls

Brains Keep Changing

We want to study how brain function and structure change in childhood. We will compare brain measures in children with and without autism spectrum disorder (ASD) who are between the ages of 10-13 years old.

Phase: Pilot

Actively recruiting: Yes

Category: Children, Healthy Controls, MRI/Imaging Studies

Healthy Controls EndoPAT

The purpose of this research study is to learn more about the normal function of blood vessels in healthy children and adolescents. This will help us discover differences between healthy individuals and children with lupus. Healthy control participants will be asked to make 1 visit to CHOP to complete a brief survey, a fasting blood draw and a test to measure the blood pressure in your fingers.

Phase: N/A

Actively recruiting: No

Category: Adults, Children, Healthy Controls, One-Time Visit Studies

Contrast-Enhanced Ultrasound Evaluation of Bowel Perfusion in Necrotizing Enterocolitis

The goal of this study is to develop ultrasound techniques that assess blood supply to the intestines using an investigational contrast agent. Our hope is to contribute to early diagnosis and improved outcomes.

Phase: N/A

Actively recruiting: No

Category: Children

Hypnotherapy in functional abdominal pain disorders

The purpose of this study is to find out if a video-guided hypnotherapy (VGH) program will improve the symptoms of those with a functional abdominal pain disorder (FAPD). This program uses guided relaxation, intense concentration, and focused attention to achieve a heightened state of awareness. These techniques can be used to help some people change certain behaviors, and it is also used to treat chronic pain. VGH does not feature direct in-person interaction with a psychotherapist (mental health professional), but rather recorded sessions that can be viewed at any time at the discretion of the patient. This study will use the video-guided hypnotherapy program that has been developed by Jeffrey Lazarus, MD, FAAP. Dr. Lazarus is a general pediatrician with an extensive background in the use of clinical hypnosis in children. He has been certified as an Approved Consultant by the American Society of Clinical Hypnosis.

Phase: Pilot

Actively recruiting: Yes

Category: Adults, Children, Remote (Online / Phone Call Only) Studies

Assessing Optically Pumped Magnetoencephalography (MEG)

The goal for this study is to compare performance between a conventional helium based “Cryo_MEG” (magnetoencephalography) system and an investigational optically pumped (‘OP_MEG’) MEG system using brain recordings from typically developing adults. MEG (magnetoencephalography) is a safe, non-invasive brain imaging method used in many forms of research as well as clinical care. MEG is measured by safely wearing a helmet filled with MEG sensors. During the MEG scan, you will be asked to look at a screen, listen to some tones, and push a button. OPM (Optically Pumped Magnetometry), is a brain imaging method that is also worn as a helmet and acquires MEG recording data but differs from conventional “cryo-MEG” because OPM sensors can be positioned closer to the head. This may present an opportunity for better measurement of underlying brain activity.

Phase: Phase I

Actively recruiting: Yes

Category: Adults, Healthy Controls, MRI/Imaging Studies, One-Time Visit Studies

Abemaciclib For Solid Tumors

The purpose of this studyis to determine the highest safe dose of abemaciclib in patients with relapsedor treatment refractory solid tumors given in combination with the chemotherapydrugs, irinotecan and temozolomide (Part A) or in combination with just temozolomide(Part B).

Phase: Phase I

Actively recruiting: No

Category: Children

Oral Desensitization

The purpose of this research study is to understand what happens to the immune systems and gut microbiomes (gut bacteria) of people who have a food allergy while they undergo an oral desensitization protocol. We will also study the immune systems and gut microbiomes of people without food allergy to better understand if the changes we see are due to oral desensitization or to natural development of these systems.

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children, Healthy Controls

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