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Promising New Preclinical Therapy Offers Hope in the Development of Precision Medicine Treatments for Aggressive Cancers

CHOP researchers developed CDX0239-PBD, a novel antibody-drug conjugate that demonstrates exceptional effectiveness against cancers expressing the ALK protein, achieving durable tumor responses in preclinical models. This breakthrough could pave the way for new precision medicine treatments, enhancing patient outcomes and reducing the side effects associated with existing therapies.

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Vaccine News & Notes — September 2025

Find recent data on vaccine coverage among teens, resources on how to assess the quality of scientific info, and a new tool that evaluates the effects of cuts to NIH grants on U.S. counties.

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First-of-its-Kind Initiative to Provide Custom-Designed, Medically Safe Backpacks to Cancer Patients

A new program within the Cancer Center at Children’s Hospital of Philadelphia (CHOP) will support caregivers to safely and comfortably manage their child’s leukemia. It’s called Backpacks With Barbara, a first-of-its-kind initiative that will provide 300 custom-designed, kid-friendly and medically safe backpacks to patients at CHOP undergoing blinatumomab therapy, a cutting-edge immunotherapy used to treat B-cell acute lymphoblastic leukemia.

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Preventing Kidney Stones

Kidney stones have become more common among children and young adults over the past few decades. Get expert advice that everyone can follow to prevent kidney stones.

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