Researchers at Children’s Hospital of Philadelphia (CHOP) have elucidated the significant role that alternative splicing – a process whereby a single gene produces multiple proteins by rearranging its messenger RNA segments in different combinations – plays in resistance to chemotherapy in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). The study published today in the journal Cancer Research.

The vaccine is the first mRNA vaccine against C. difficile and would be the first vaccine in general to successfully ward off the bacterial infection.

Researchers aim to develop personalized therapies for urea cycle disorders and other genetic conditions using advanced CRISPR technology.

We are honored to announce that CHOP has been given the NOD Leading Disability Employer Seal for 2024 by the National Organization on Disability (NOD) for the fourth time.

Find info about influenza deaths in children during the 2023-24 season and check out new RSV Q&A sheets.

Watch as Dr. Handy discusses the history of vaccine mandates and the role they play in keeping children healthy today.

Find resources related to vaccine ingredients. Plus, get tools to help evaluate information about this and other science-based topics.

This award will help research, validate and implement a new model for sharing and integrating data at a national level.

On a September Sunday on the Ben Franklin Parkway, nearly 8,000 supports – comprising of more than 275 teams – participated in CHOP Cancer Center’s largest fundraiser, the Parkway Run & Walk, presented by Citadel Credit Union.

Leaders from CHOP's Youth Heart Watch and the School District of Philadelphia present certificates to six schools recognizing their Heart Safe School status.