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Children’s Hospital of Philadelphia Researchers Discover Underlying Mechanisms that Make CRISPR an Effective Gene Editing Tool
Using state-of-the-art technology, researchers say understanding underlying movements and mechanisms may pave the way for more effective forms of CRISPR-based therapy.
Children’s Hospital of Philadelphia Researchers Find Hemophilia A Drug May Be Effective for Select People with Hemophilia B
Researchers at Children’s Hospital of Philadelphia (CHOP) found that emicizumab, a widely used drug for hemophilia A, could also improve blood clotting for select people with hemophilia B depending on their genes. The preclinical study, recently published in Blood, offers proof that this class of hemophilia A drug could potentially be used to treat hemophilia B.
$14M NIH grant funds gene-editing research for rare metabolic diseases at Penn and CHOP
Researchers aim to develop personalized therapies for urea cycle disorders and other genetic conditions using advanced CRISPR technology.
Penn Medicine and Children’s Hospital of Philadelphia Create mRNA Vaccine to Prevent and Treat C. difficile
The vaccine is the first mRNA vaccine against C. difficile and would be the first vaccine in general to successfully ward off the bacterial infection.
Researchers at Children’s Hospital of Philadelphia Highlight Role of Alternative Splicing in Chemotherapy Resistance
Researchers at Children’s Hospital of Philadelphia (CHOP) have elucidated the significant role that alternative splicing – a process whereby a single gene produces multiple proteins by rearranging its messenger RNA segments in different combinations – plays in resistance to chemotherapy in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). The study published today in the journal Cancer Research.
Brighten up the season
This year, many children will spend the holidays in the hospital. Brighten the season for them and their families by creating a virtual toy drive—a fun and easy way to raise funds to buy gifts for kids in CHOP this holiday season.
Headache Case Study: When to Worry, When to Treat
This case study discusses when primary care professionals should refer their patients to a specialist.
Case Study: When Spinal Surgery Can Improve Mobility for Children with Spastic Diplegic Cerebral Palsy
Read this case study to learn how spinal surgery can help improve mobility for children with spastic diplegic cerebral palsy.
Corporate Community’s Impactful Day
At CHOP's Helping Hands event, volunteers engaged in a day of service to fundraise and make kits for patients.
CHOP, University of Pittsburgh Researchers Demonstrate Modified Health Questionnaire is Better at Predicting Suicidal Behavior Among Teens
Three questions on modified health questionnaire were more likely to predict suicidal behavior within one year of screening