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Researchers at Children’s Hospital of Philadelphia Reveal New Insights into Non-Inflammatory Causes of Rare Neurological Symptoms in Children, Adolescents and Young Adults Following CAR-T Therapy
Researchers at Children’s Hospital of Philadelphia (CHOP) revealed for the first time that children, adolescents and young adults may experience very rare neurological issues of paraparesis and quadriparesis following chimeric antigen receptor T-cell (CAR-T) therapy, a type of immunotherapy used to treat B-cell Acute Lymphoblastic Leukemia (B-ALL). Additionally, these complications occurred without the type of inflammation typically seen in adults. The findings were published today in the journal Blood.
First Patients at CHOP Begin Newly Approved Sickle Cell Gene Therapies
CHOP announced that its first patients outside of clinical trials have begun the treatment process for the newly FDA approved sickle cell gene therapies.
A Breath of Fresh Air
A gift from the Wyss Foundation elevates CHOP's research in thoracic insufficiency syndrome, a rare and complex condition.
A Decade of Holistic Healing
The Integrative Health Program empowers patients to take charge of their recovery.
A Day in the Life: A Seating Clinic Physical Therapist
At the Seating and Adaptive Equipment Clinic, Emma McKenzie, PT, DPT, works with children who have mobility issues.
Overcoming Fears and Empowering Other Kids
Inspired by her own journey, a CHOP patient helps other children deal with the stress of managing an illness.
Grant Will Provide Transformative Career Opportunities
A new partnership between CHOP and a local high school aims to lift families out of poverty.
New Avenues
CHOP researchers are aiming to treat a wider range of cancers by reaching previously “unreachable” drug targets.
News & Views — RSV Prevention in Adults: A Year in Review
Find info about RSV vaccines for older adults, including updates to vaccine recommendations, new data on vaccine safety and efficacy, and more.
In the Journals: Pediatric Influenza Deaths Largely Preventable Through Vaccination
A recent study by the CDC underscored the importance of influenza vaccination of children.