Research News from CHOP
Children’s Hospital of Philadelphia Researchers Find Evidence That Tumor Necrosis Factor Alpha Helps Reduce Anemic Inflammation
Researchers at Children’s Hospital of Philadelphia (CHOP) found compelling preclinical evidence that a molecule called tumor necrosis factor alpha (TNFα), typically known for promoting inflammation, also plays a helpful role in recovery from anemia that is caused by ongoing immune disturbances.
Children’s Hospital of Philadelphia Researchers Discover Previously Hidden Brain Event During Electroconvulsive Therapy (ECT)
Researchers at Children’s Hospital of Philadelphia (CHOP) discovered a previously unrecognized brain event following electroconvulsive therapy (ECT), the most clinically effective treatment for severe, medication-resistant depression. The findings, which could provide additional insight into the biological mechanism of ECT, were recently reported in the journal Nature Communications.
Transformational $50 million gift will launch the Lurie Autism Institute at Children’s Hospital of Philadelphia and Penn Medicine
A $50 million gift to Children’s Hospital of Philadelphia (CHOP) and Penn Medicine will create an ambitious joint initiative called the Lurie Autism Institute to drive discoveries with transformative impact for those living with autism spectrum disorder (ASD). The gift, from the Lurie family, is the largest single donation to U.S. academic medical centers focused on autism research across the lifespan.
Children’s Hospital of Philadelphia Researchers Show Quality Improvement Initiative in the Emergency Department Improved Family Engagement Around Firearm Safety Resources
Researchers in the Center for Violence Prevention (CVP) at Children’s Hospital of Philadelphia (CHOP) embarked on a quality improvement (QI) initiative with behavioral health patients at CHOP’s Philadelphia and King of Prussia emergency departments with the goal of improving firearm safety conversations.
Pediatric Thyroid Center at Children’s Hospital of Philadelphia Performs 1,000th Thyroid Surgery
Children’s Hospital of Philadelphia (CHOP) reached a significant milestone — performing its 1,000th pediatric thyroid surgery in February. The Pediatric Thyroid Center at CHOP, which treats children and teens with thyroid disease, thyroid nodules, thyroid cancer, and other endocrine related disorders, is one of the busiest and most advanced U.S. centers of its kind.
Children’s Hospital of Philadelphia Researchers Show Stem Cell Transplant Offers Potentially Curative Therapy in Pediatric Patients with Monogenic Inflammatory Bowel Disease
A collaborative team of researchers from Children’s Hospital of Philadelphia (CHOP) found that hematopoietic stem cell transplantation is a highly effective method for treating patients with monogenic inflammatory bowel disease (IBD), a more severe form of the illness usually affecting younger patients.
Children’s Hospital of Philadelphia Researchers Develop Promising Tools to Enhance Gene Therapy Delivery for Hard-to-Treat Diseases
Researchers at CHOP established a transformative advance in gene therapy, demonstrating how new generations of AAV vectors can target relevant brain cells and structures at much lower doses than current AAV based drugs.
Children’s Hospital of Philadelphia Researchers Find Pediatric Patients May Be at an Increased Risk of Kidney Problems after COVID-19 Infection
Researchers at Children’s Hospital of Philadelphia (CHOP) found that children and adolescents who had SARS-CoV-2 infection (COVID-19) were at a higher risk of developing kidney-related complications, especially if they have preexisting chronic kidney disease (CKD) and experienced decreased kidney function while actively infected.
Children’s Hospital of Philadelphia Researchers Recommend New Standard of Care for Families with Hereditary Neuroblastoma Linked to ALK Mutation
Researchers at Children’s Hospital of Philadelphia (CHOP) highlighted the success of anaplastic lymphoma kinase (ALK) inhibition therapy in treating hereditary neuroblastoma, a rare subset of a common childhood cancer. Researchers suggest that the findings, published recently in JCO Precision Oncology, could help establish a new standard of care.
Preclinical Study from Children’s Hospital of Philadelphia Highlights Innovative Approach to Replacing Brain Cells in the Treatment of Leukodystrophies
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Perelman School of Medicine at the University of Pennsylvania announced the first ever direct approach to the depletion and replacement of microglia, the native immune cells of the central nervous system (CNS).