This new method, typically used in adult patients, may spare patients from having to undergo open heart surgery.

A multimillion-dollar gift from the Topolewskis will further advance both clinical and basic science research at CHOP that is finding new solutions for kids with complex heart valve disease.

Children’s Hospital of Philadelphia (CHOP) announced that it has received a multi-million dollar gift from the Topolewski family, longstanding supporters of the Cardiac Center at CHOP, to establish the Topolewski Pediatric Heart Valve Center.

Two research teams in CHOP’s Cardiac Center have been awarded research grants to study single ventricle congenital heart disease.

Researchers in CHOP’s Pediatric Heart Valve Center have found that the neurotransmitter serotonin can adversely affect the heart’s mitral valve, contributing to a heart disease known as degenerative mitral regurgitation.

The co-directors of CHOP’s Cardiac Center highlight some of the biggest recent breakthroughs in pediatric cardiology along with one change they would like to see.

CHOP researchers have found that modifying bioprosthetic heart valves (BHV) with a polymer known as POZ prevents structural degeneration of the valve.

CHOP researchers participated in clinical trial that led to approval of Harmony™ Transcatheter Pulmonary Valve (TPV), which allows for valve replacement without open-heart surgery.

Learn more about the pioneering team behind the breakthroughs at the Topolewski Pediatric Heart Valve Center.

Muhammad Nuri, MBBS, talks breakthroughs — the ones he’s made and the ones he looks forward to.