The purpose of this study is to assess the efficacy, safety, and how the body interacts with an investigational drug in pediatric patients with Crohn's disease who have not had success with other medications. After study participants are screened, if eligible, they will receive the study drug. The study drug in this study is called Upadacitinib. While Upadacitinib is FDA-approved for use in adults with Crohn's Disease, it is investigational for children with Crohn's Disease.

This study seeks to characterize dietary intake in children with IBS and explore severity of symptoms and quality of life. This study uses the G-Tech wireless patch system to define patterns of gut motility in patients with IBS and associate these patterns with dietary intake and GI symptoms. Participants will wear the patches for 7 days as a part of the study. They can be worn under clothing and participants can continue daily activities other than swimming, bathing (although they can shower), and exercising. Stool and urine samples will also be collected to explore the gut microbiome and its association with IBS symptoms, diet, and patterns of gut motility.

We are looking to partner with patients with a confirmed diagnosis of IBS between 8 and 18 years of age who are undergoing dietary modifications such as a low-FODMAP (fermentable oligosaccharides, disaccharides, monosaccharides and polyols) diet.

Teens ages 14-17 with BMI in the 85th percentile or above and without diabetes are invited to participate in the HEALTHY BITES Research Study. The purpose of this research study is to find out if we can develop a mobile health approach that can improve diet quality in teens.

The purpose of this study is to find out if a video-guided hypnotherapy (VGH) program will improve the symptoms of those with a functional abdominal pain disorder (FAPD). This program uses guided relaxation, intense concentration, and focused attention to achieve a heightened state of awareness. These techniques can be used to help some people change certain behaviors, and it is also used to treat chronic pain. VGH does not feature direct in-person interaction with a psychotherapist (mental health professional), but rather recorded sessions that can be viewed at any time at the discretion of the patient. This study will use the video-guided hypnotherapy program that has been developed by Jeffrey Lazarus, MD, FAAP. Dr. Lazarus is a general pediatrician with an extensive background in the use of clinical hypnosis in children. He has been certified as an Approved Consultant by the American Society of Clinical Hypnosis.