Research Studies

Division of Gastroenterology, Hepatology and Nutrition Research Studies

Find research studies available to children cared for by the Division of Gastroenterology, Hepatology and Nutrition team.
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Clinical trial
Children (14)
Adults (9)
Healthy Controls (4)
One-Time Visit Studies (3)
Remote (Online / Phone Call Only) Studies (3)

Clinical Trial Phases
Pilot (2)
Phase I (1)
Phase II (1)
N/A (10)

Recruitment Status
Recruiting (9)
Non-recruiting (5)

Related Specialties and Programs
Division of Gastroenterology, Hepatology and Nutrition (14)
Department of Pediatrics (2)
Center for Pediatric Inflammatory Bowel Disease (1)

Specialty
Gastroenterology (14)
General Pediatrics (2)

AA Genetic Study
The purpose of this study is to compare the genes of African American children and adults who have inflammatory bowel disease (IBD) with the genes of those who do not have IBD. Genes are pieces of hereditary material found in human cells. How an individual's genes cause intestinal inflammation in IBD is still being tested and not much is known about the association between genes and IBD in individuals with African ancestry. We hope to understand which genes cause IBD and if certain genes can help doctors personalize treatment for patients with IBD. For more information please contact IBDResearch@email.chop.edu. 

Phase: N/A

Actively recruiting: No

Category: Adults, Children

Bio Repository
The purpose of this research study is to collect different types of samples (such as stool, swabs, urine) to form a biorepository. This repository will provide valuable samples from people with and without IBD so that investigators can learn more about the cause of IBD, and different therapies that could be used to treat it. These samples will be used for future gastrointestinal research. Because technology and scientific understanding may advance quickly, it is not yet known what specific studies the samples may be used for. 

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children, Healthy Controls

ENCODE
The purpose of this investigation is to evaluate the impact of non-persistent and persistent chemical exposures on autoimmunity, gene expression and the microbiome in children with and without Crohn’s disease. If these chemical exposures are associated with differences in the epigenome and microbiome that are known to predispose for Crohn’s disease, the proposed research could further support changes in dietary behaviors to limit exposure, and efforts to regulate manufacturing processes that unintentionally and intentionally add these chemicals to food.

Phase: N/A

Actively recruiting: No

Category: Adults, Children, Healthy Controls

HEALTHY BITES
Teens ages 14-17 with BMI in the 85th percentile or above and without diabetes are invited to participate in the HEALTHY BITES Research Study. The purpose of this research study is to find out if we can develop a mobile health approach that can improve diet quality in teens. 

Phase: Pilot

Actively recruiting: Yes

Category: Children, One-Time Visit Studies, Remote (Online / Phone Call Only) Studies

Hypnotherapy in Functional Abdominal Pain Disorders
The purpose of this study is to find out if a video-guided hypnotherapy (VGH) program will improve the symptoms of those with a functional abdominal pain disorder (FAPD). This program uses guided relaxation, intense concentration, and focused attention to achieve a heightened state of awareness. These techniques can be used to help some people change certain behaviors, and it is also used to treat chronic pain. VGH does not feature direct in-person interaction with a psychotherapist (mental health professional), but rather recorded sessions that can be viewed at any time at the discretion of the patient. This study will use the video-guided hypnotherapy program that has been developed by Jeffrey Lazarus, MD, FAAP. Dr. Lazarus is a general pediatrician with an extensive background in the use of clinical hypnosis in children. He has been certified as an Approved Consultant by the American Society of Clinical Hypnosis.

Phase: Pilot

Actively recruiting: Yes

Category: Adults, Children, Remote (Online / Phone Call Only) Studies

New Pediatric IBD Therapies

The purpose of this study is to help understand how well new IBD medications work, obtain safety information, and understand patient's quality of life while on the medications.

Phase: N/A

Actively recruiting: Yes

Category: Children

PAIR
The purpose of this study is to characterize the microbiome in children with Crohn’s disease who have perianal fistula and to compare it to other children with Crohn’s disease who do not have perianal disease. Studying the role of the microbiome in perianal fistula may help us to develop new therapies.

Phase: N/A

Actively recruiting: No

Category: Adults, Children

Pedaitric Study of Acute Recurrent and Chronic Pancreatitis
The goals of this research study are to learn more about acute recurrent and chronic pancreatitis in order to better understand the disease in the hopes of enhancing future treatment options. If you and your child agree to participate you will each be asked to: meet with the study team at your annual check-up, complete questionnaires about medical history, family history, and quality of life, agree to a one-time blood or saliva sample collection. All participants will be compensated for their time and effort. If you would be interested in participating, please contact study coordinator Lucia Sanchez by phone at 267-426-8411, or email at sanchezlc@email.chop.edu. 

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children, One-Time Visit Studies

Polyethylene Glycol Safety in Children

This study was designed to measure components or metabolites of PEG 3350 in blood and urine from children who were already taking PEG 3350 and to compare these levels to measurements of the same molecules from a group of children who were not taking PEG 3350. PEG 3350 was not prescribed as part of this study. Participants completed questionnaires and provided access to their medical records.Enrollment for this study has been completed. Laboratory analysis of specimens and data analysis are being conducted. This work will be submitted for publication once all analyses have been completed. When available, study results will be accessible on https://classic.clinicaltrials.gov/ct2/show/NCT05424757.

Phase: N/A

Actively recruiting: No

Category: Children, Healthy Controls

RE-EEN Smoothie Study

The RE-EEN Smoothie Study is recruiting patients newly diagnosed with Crohn's Disease who are interested in using diet to help achieve disease remission. The purpose of the study is to evaluate the use of a whole-food based smoothie as Exclusive Enteral Nutrition for Crohn's Disease. In this study, participants will be randomly assigned to receive either a whole-food based smoothie, or formula as Exclusive Enteral Nutrition (EEN) therapy for Crohn's Disease. Participants will work closely with the study dietician to ensure that all of their nutritional needs are met during their participation in the study. 

Phase: Phase II

Actively recruiting: Yes

Category: Adults, Children