The primary goal of this research study is to learn if patients with autosomal recessive polycystic kidney disease (ARPKD) are at risk for brain aneurysms or cardiovascular abnormalities.Participants in this study will involve patients that have a clinical diagnosis of ARPKD.The study will also involve a comparison group of healthy individuals that have no history of kidney or cardiac conditions.

iTONE will study the impact of a 4-month home exercise program on physical activity levels, skeletal muscle mass and strength, functional health status, and quality of life in children and teenagers with pulmonary hypertension. Participants will receive home exercise prescriptions from the CHOP exercise trainers, tailored to their interests and abilities. Participants will wear a smartwatch that tracks activity and communicates with a digital health platform connected to the study team.

This pilot study is investigating the feasibility of a prospective biomarker study in the CICU by measuring enrollment of subjects, as well as the looking at outcomes. The goal of this study is to risk stratify neonates with congenital heart disease requiring neonatal cardiopulmonary bypass for poor outcomes in order to appropriately tailor medical care and for possible future trials.