The primary objective of this study is to collect biospecimens to conduct protein biomarker studies in patients with heart failure requiring advanced therapies such as OHT and VAD. A dedicated heart failure biospecimen repository will allow the Cardiac Center to be at the forefront of molecular sub-phenotyping to improve mechanistic understanding, clinical care, and trial design.

The primary goal of this research study is to learn if patients with autosomal recessive polycystic kidney disease (ARPKD) are at risk for brain aneurysms or cardiovascular abnormalities.Participants in this study will involve patients that have a clinical diagnosis of ARPKD.The study will also involve a comparison group of healthy individuals that have no history of kidney or cardiac conditions.

The study will measure both myocardial dysfunction and inflammation as it is related to the severity of cardiac arrest, and their association with post-cardiac arrest morbidity and mortality. The study will also determine how the change in both myocardial function and inflammatory markers over time is association with outcomes.

iTONE will study the impact of a 4-month home exercise program on physical activity levels, skeletal muscle mass and strength, functional health status, and quality of life in children and teenagers with pulmonary hypertension. Participants will receive home exercise prescriptions from the CHOP exercise trainers, tailored to their interests and abilities. Participants will wear a smartwatch that tracks activity and communicates with a digital health platform connected to the study team.

The purpose of this research study is to learn more about improving the treatment and outcomes for patients who have a diagnosis of a single ventricle, such as Hypoplastic Left Heart Syndrome (HLHS) or similar heart defects. You will be asked to fill out a questionnaire called the Ages and Stages Questionnaire about your child. It is used widely in pediatrics to check on babies development. We will ask you to fill this out about every three months during your childs 15 months of life. Also, information will be collected about your childs surgeries, clinic visits and hospital stays from diagnosis through the first year of life. The information may be used to help us understand an infant's response to surgery and medical treatment and may be used to improve care for children with single ventricles.

This pilot study is investigating the feasibility of a prospective biomarker study in the CICU by measuring enrollment of subjects, as well as the looking at outcomes. The goal of this study is to risk stratify neonates with congenital heart disease requiring neonatal cardiopulmonary bypass for poor outcomes in order to appropriately tailor medical care and for possible future trials.