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Researchers at Children’s Hospital of Philadelphia Highlight Role of Alternative Splicing in Chemotherapy Resistance
Researchers at Children’s Hospital of Philadelphia (CHOP) have elucidated the significant role that alternative splicing – a process whereby a single gene produces multiple proteins by rearranging its messenger RNA segments in different combinations – plays in resistance to chemotherapy in relapsed or refractory B-cell acute lymphoblastic leukemia (B-ALL). The study published today in the journal Cancer Research.
Penn Medicine and Children’s Hospital of Philadelphia Create mRNA Vaccine to Prevent and Treat C. difficile
The vaccine is the first mRNA vaccine against C. difficile and would be the first vaccine in general to successfully ward off the bacterial infection.
$14M NIH grant funds gene-editing research for rare metabolic diseases at Penn and CHOP
Researchers aim to develop personalized therapies for urea cycle disorders and other genetic conditions using advanced CRISPR technology.
CHOP Cell and Gene Therapy Researcher Receives NIH New Innovator Award
Evan Weber will use this “high risk, high reward” grant to fund research into improving CAR-T therapies.
Researchers at Children’s Hospital of Philadelphia Highlight Benefits of Proton Therapy for Pediatric Hodgkin Lymphoma Patients
A new study from Children’s Hospital of Philadelphia (CHOP) showed promising results for Pediatric Hodgkin Lymphoma (pHL) patients who underwent proton therapy to treat their disease in rare regions located below the diaphragm, such as the abdomen and pelvis. The study highlights the advantages of proton therapy over conventional photon radiotherapy, demonstrating fewer side effects and better protection for critical organs. It was published recently in the journal Pediatric Blood and Cancer.
Children’s Hospital of Philadelphia’s 22nd Annual Parkway Run & Walk presented by Citadel Credit Union Raises More than $1.95 Million to Bolster Pediatric Cancer Research and Care
On a September Sunday on the Ben Franklin Parkway, nearly 8,000 supports – comprising of more than 275 teams – participated in CHOP Cancer Center’s largest fundraiser, the Parkway Run & Walk, presented by Citadel Credit Union.
Children’s Hospital of Philadelphia Successfully Separates Conjoined Twin Boys
After nearly a year at Children’s Hospital of Philadelphia (CHOP), conjoined twins Amari and Javar Ruffin were successfully separated by CHOP surgeons on August 21, 2024.
Children’s Hospital of Philadelphia Named a 2024 Leading Disability Employer by the National Organization on Disability
Children’s Hospital of Philadelphia (CHOP) is honored to announce that it has received a Leading Disability Employer Seal for 2024 from the National Organization on Disability (NOD).
Doylestown Pediatricians at Two Upcoming Events in the Community
Parents and caregivers are invited to attend our community events this October presented by CHOP Primary Care, Doylestown, in partnership with local organizations.
Children’s Hospital of Philadelphia Researchers Find Extreme Heat Can Impact Youth Mental Health, Contributing to Aggression in Pre- and Early Adolescents
A new study from researchers at Children’s Hospital of Philadelphia (CHOP) found racial and ethnic disparities in pre- and early adolescent exposure to extreme heat, as well as a small but significant association between extreme heat and specific behavioral symptoms like aggression. The study was recently published in the journal JAACAP Open, the open-access journal of the American Academy of Child and Adolescent Psychiatry.