Jane E. Minturn, MD, PhD
Areas of expertise: Pediatric brain and spine tumors, Early phase clinical trials in neuro-oncology, International medicine
About Jane E. Minturn, MD, PhD
My clinical practice is limited to caring for patients with brain and spinal cord tumors as a member of the multidisciplinary Brain Tumor Program. Our team includes specialists in Neuro-Oncology, Neurology, Neurosurgery, Radiation Oncology, and Neuropsychology along with skilled nurse practitioners. There is a broad spectrum of expertise that The Children's Hospital of Philadelphia brings to treating its patients with brain tumors.
Treating cancer is a team effort at Children's Hospital, and we consider patients and their families as part of the team. Since our young patients are dependent on their parents for medical decision-making, I try to give them a sense of some control over their disease, communicating in an age appropriate manner. Kids do much better when they are part of the treatment plan and "secrets" are not kept from them.
My research is focused on developing personalized and targeted therapeutics in tumors of the nervous system and understanding the late effects of our therapies in long-term survivors.
As part of our approach to identifying new treatments for children with brain tumors, we are members of the multi-institutional Pacific Pediatric Neuro-Oncology Consortium (PNOC) and a Children's Oncology Group (COG) Phase 1 Institution. These groups are involved in early phase clinical trials for relapsed and refractory brain tumors, with a particular focus on testing new, targeted treatments in children with brain tumors.
Our Children's Hospital team has partnered with drug development groups, and we are rapidly identifying drugs that show promise in patients with brain tumors who have no other curable option. There is a sense of urgency in our group — working collaboratively with laboratory scientists and drug development companies on rational, biologically-based therapies.
There is huge progress in getting promising drugs to children with cancer. Through our cooperative group consortia, the pace is much more rapid than in past years, and Children's Hospital is a major part of the effort to help bring new agents to children with brain tumors.
Titles
Attending Physician
Clinical Associate Professor, Perelman School of Medicine at the University of Pennsylvania
Certifications
Pediatric Hematology-Oncology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Awards and Honors
2010, Hyundai Hope on Wheels, Hope Grant Award Winner
2010, Advances in Neuroblastoma Research Annual Meeting: Best Clinical Poster Award, Stockholm, Sweden
2006-2009, American Cancer Society Mentored Research Scholar Grant
2004-2006, Wolfson Scholar in Neuroblastoma Research
2003-2006, American Society of Clinical Oncology Career Development Award
2003, Florence R.C. Murray Program Fund Award
2002-2003, American Society of Clinical Oncology Young Investigator Award
2000, Selected Participant, American Association for Cancer Research Workshop, Molecular Biology in Clinical Oncology, The Given Institute, Aspen, CO
1989-1996, Pre-doctoral Fellowship, Howard Hughes Medical Institute
1988, Medical Student Research Fellowship, American Heart Association
1986, 1986 Phi Kappa Phi, University of Southern California
1986, 1986 Phi Beta Kappa, University of Southern California
1986, 1986 Summa Cum Laude, University of Southern California
Leadership and Memberships
Memberships in Professional Organizations
American Association for Cancer Research
American Society of Clinical Oncology
American Society of Pediatric Hematology/Oncology
Children’s Oncology Group (COG)
Pediatric Brain Tumor Consortium
Institutional Principal Investigator
Society for Neuro-Oncology
Pacific Pediatric Neuro-Oncology Consortium
- Institutional Principal Investigator
Editorial and Academic Positions
Editorial positions
Reviewer
Clinical Cancer Research
Journal of Neuro-Oncology
Neuropediatrics
Pediatric Blood & Cancer
Pediatric Drugs
Neuropsychiatric Disease and Treatment
Academic and Institutional Committees
2015-present, Oncology Liaison, International Medicine
2013-present, Clinical Competency Committee
2011-present, Targeted Therapy Glioma Group
2010-present, Proton Therapy Triage Committee
2008-present, Pediatric Protocol Review Committee
2006-present, Pediatrics Residency Program Faculty Interviewer
Education & training
Undergraduate Degree
University of Southern California (BS, psychobiology), Los Angeles, Calif.
Graduate Degree
PhD in Neurobiology - Yale University, New Haven, CT
MPhil - Yale University, New Haven, CT
Medical Degree
MD - Yale University School of Medicine, New Haven, CT
Internship
Pediatrics - The Children’s Hospital, Boston, MA
Residency
Pediatrics - The Children's Hospital, Boston, MS
Fellowship
Hematology/Oncology, The Children's Hospital of Philadelphia, Philadelphia, Pa.
Publications
Publications
2015
Shah AC, Cole KA, Waanders AJ, Minturn JE, Fisher MJ, Hill-Kayser C. Proton radiation therapy effect mimicking radiologic relapse in two young adults with pure CNS germinoma. Pediatric Blood and Cancer, 2015 (in review).
Frick M, Minturn JE, Li Y, Hill-Kayser CE. Radiotherapy-related outcomes in pediatric patients with atypical teratoid rhabdoid tumor of the central nervous system. Journal of Pediatric Hematology/Oncology, 2015 (in review).
Shah AC, Minturn JE, Li Y, Belasco JB, Phillips PC, Kang TI, Cole KA, Waanders AJ, Pollack R, Didomenico C, Wildes C, Fisher MJ. Carboplatin rechallenge after hypersensitivity reactions in pediatric patients with low-grade glioma. Pediatric Blood and Cancer, 2015 (in press).
Lectures by Invitation
2015
From the Office through Treatment and Survivorship: Pediatric Brain Tumors. CME Lecture Series in Pediatric Oncology, Bridgewater NJ, March 2015.
2014
Neurocognitive effects of brain tumor therapy in children. Pediatric Brain Tumor Foundation, Valley Forge Christian College, Phoenixville, PA, September 2014.
2013
Advances in Precision Medicine for Pediatric Brain Tumors. Pediatric Brain Tumor Foundation Annual Ride for Kids Program, Valley Forge Christian College, Phoenixville, PA, September 2013.
Books
Chapters
2015
Minturn JE and Fisher MJ: Brain Tumors, In: Schwartz MW (ed), The 5-Minute Pediatric Consult, 7th Edition, Philadelphia: Wolters Kluwer, 2015, p.124-125.
2013
Zhi W, Minturn J, Rappaport E, Brodeur G, Li H: Network-based analysis of multivariate gene expression data. In: Statistical Methods for Microarray Data Analysis, vol 972, Yakovlev AY, Klebanov L, and Gaile D, (eds). Humana Press, Totowa, NJ, Pp. 121-139, 2013.
2012
Minturn JE: Teratoma, In Schwartz MW (ed), The 5-Minute Pediatric Consult, 6th Edition, Lippincott Williams & Wilkins, Philadelphia, PA. Pp. 864-865, 2012.
2011
Sievert AJ, Minturn JE. Brain tumors. In: Florin TA, Ludwig S, editors. Netter's pediatrics. Philadelphia: Elsevier Publishing; 2011.
2008
Fisher MJ, Minturn J, Phillips PC. Brain tumors. In: Brodeur GM, Manno CS, editors. Pediatric hematology/oncology: the requisites in pediatrics. Philadelphia: C.V. Mosby Publishing; 2008.
Minturn JE. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2008. p. 840-41.
2005
Minturn JE. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 834-35.
2002
Minturn JE, Friedman DL. Teratoma. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 812-13.
Minturn JE. Idiopathic thrombocytopenic purpura. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 464-65.
Minturn JE, Kelly KM. Hemophilia. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 420-21.
Minturn JE, Kelly KM. Aplastic anemia. In: Schwartz MW, editor. The 5-minute pediatric consult. 5th ed. Philadelphia: Lippincott Williams & Wilkins; 2002. p. 130-31.