Peter J. Madsen, MD, MBE
Areas of expertise: Brain and spinal cord tumors, Congenital spine disorders, Craniofacial disorders, Hydrocephalus, Brain and spine trauma, Peripheral nerve tumors
Locations: Main Building
About Peter J. Madsen, MD, MBE
As a Pediatric Neurosurgeon at the Children’s Hospital of Philadelphia, I have the privilege of treating children and young adults with various conditions of the brain, spine, and peripheral nervous system. I have a broad interest in all aspects of pediatric neurosurgery and provide surgical care for patients with tumors of the brain and spinal cord, congenital spine disorders, craniofacial abnormalities, hydrocephalus, traumatic brain and spine injuries, and tumors of the peripheral nervous system. I strive for a collaborative approach to decision-making as I work closely with patients and their families to find the best possible surgical or non-surgical treatments for their conditions.
I have a particular interest in the care of children and young adults with brain tumors, such as medulloblastoma, ependymoma, AT/RT, diffuse midline glioma, and low-grade glioma. I collaborate with my colleagues in the Pediatric Neuro-Oncology Program at CHOP to treat children and young adults with these challenging diseases. Whether I am caring for a patient with a newly diagnosed brain tumor or meeting with a family seeking a second opinion, the goal is always to achieve the best outcome in the safest way possible that maximizes a patient’s chances for long-term health and happiness. Whenever possible, we strive to use the most advanced and minimally invasive techniques, including microsurgery, endoscopic surgery, and laser interstitial thermal ablation.
While surgery is an important part of the care for patients with brain tumors, it is essential that our team investigate and develop new and comprehensive brain tumor therapies. I spend much of my time pursuing research efforts to develop new, targeted treatments that will hopefully one day spare children from risks of surgery and the side-effects of currently available treatments. I have a particular interest in bringing developments in the field of immunotherapy to the treatment of children and young adults with brain tumors. Through various grants and collaborative partnerships with CHOP neuro-oncologists, I direct laboratory efforts testing CAR-T cell therapies for multiple types of pediatric brain tumors with the hope of translating these approaches into clinical trials.
As a parent myself, I appreciate the level of trust that parents must place in a surgeon when their child needs pediatric neurosurgical care. I am so fortunate to be a part of an incredible team of doctors, nurses, therapists, and support staff at CHOP who are united in providing exceptional care for our patients. This team-based approach that puts children and their families at the center of their care makes all the difference, allowing us to provide the highest quality treatment with compassion and dedication.
Titles
Attending Neurosurgeon, Division of Neurosurgery
Director, Neuro-oncology and Translational Research, Division of Neurosurgery
Assistant Professor of Neurosurgery, Perelman School of Medicine at the University of Pennsylvania
Awards and Honors
2023 Matt Larson Foundation Iron Matt Award
2023 CHOP Foerderer Award
2022-24 CHOP K-Readiness Pilot Program
2022 – 2023 Neurosurgery Research & Education Fund Young Clinician Investigator Award
2022 – 2023 American Society of Spine Radiology Grant
2020, Penn Health Tech Pilot Award
2018, AANS/CNS Tumor Section, Columbia Softball Charity Award
2012-2013, Class of 1949 Medical Student Scholarship
2011, CHOP Pediatric Neurosurgery Medical Student Fellows Research Program
2009-2013, Samuel Bellet Scholarship, University of Pennsylvania, Center for Bioethics
2009, Kevin Heaney and Judi Marvel Brain Tumor Research Fellowship
2008-2012, Schlesinger Medical Student Scholarship
2008, University Honors, Carnegie Mellon University
2008, Sigma Xi, Research honor society
2008, Senior Leadership Award, Carnegie Mellon University
2007, HHMI Undergraduate Student Research Travel Award
Leadership and Memberships
Memberships in Professional Organizations
2022 – present Society for Neuro-Oncology
2021 – present Investigator, Philadelphia Coalition for a Cure
2019 – 2021 AANS/CNS Joint Section on Pediatric Neurological Surgery, Communications Subcommittee Member
2018 – present Investigator, Pacific Neuro-Oncology Consortium (PNOC)
2013 – present Pennsylvania Neurosurgical Society
2013 – present Congress of Neurological Surgeons
2012 – present American Academy of Neurological Surgery
2011 – present AANS/CNS Joint Section on Pediatric Neurological Surgery
Education & training
Graduate Degree
Masters of Bioethics - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Medical Degree
MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Residency
Neurological Surgery - Hospital of the University of Pennsylvania, Philadelphia, PA
Fellowship
Neurosurgical Oncology and Skull Base Surgery - Wellington Regional Hospital, Wellington, New Zealand
Pediatric Neurosurgery - Children's Hospital of Philadelphia, Philadelphia, PA
Publications
Publications
2022
Madsen PJ, Hollawell ML, Santi M, Surrey LF, Vossough A, Orr BA, Tucker AM, Storm PB, Foster JF. Diffuse leptomeningeal glioneuronal tumor in a child masquerading as an intramedullary spinal pilocytic astrocytoma. 2022. In review.
Tucker AM, Madsen PJ, Coyle AM, King H, Zahner C, Lang SS, Taylor JA, Heuer GG. Preprocedural Electrophysiological Monitoring in Craniofacial Surgery for a Patient with Chiari Malformation. Cleft Palate Craniofac J. 2022; epub ahead of print.
Foster JB, Griffin C, Rokita JL, Stern A, Brimley C, Rathi K, Lane MV, Buongervino SN, Smith T, Madsen PJ, Martinez D, Wechsler-Reya RJ, Kariko K, Storm PB, Barrett DM, Resnick AC, Maris JM, Bosse KR. Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. J. Immunother. Cancer. 2022; 10(9): e004450.
Shaprio JA, …, Madsen PJ, …, Taroni JN. An open pediatric brain tumor atlas. 2022. https://alexslemonadegithub.io/OpenPBTA-manuscript/v/7207b5942e7207c7205ee7208a7363f7202cc 7254c7204a7278ec7206f7810e/
Punchak MA, Hollawell ML, Viaene AN, Cahill AM, Storm PB, Madsen PJ, Tucker AM. Large scalp venous malformation in a pediatric patient managed with sclerotherapy and surgery: a case report and review of literature. Child’s Nerv Syst. 2022; epub ahead of print.
Rahman RK, Tomlinson SB, Katz J, Galligan K, Madsen PJ, Tucker AM, Kessler SK, Kennedy BC. Stereoelectroencephalography Before Age Two. Neurosurg. Focus. 2022; epub ahead of print.
Fischer KM, Madsen PJ, Tucker AM, Long CJ. Thoracic spinal arachnoid cyst in a pediatric patient presenting with isolated bladder and bowel incontinence. Urol. Case Rep. 2022; 44, epub ahead of print.
Madsen PJ, Rahman RK, Patel YA, Lang SS, Storm PB, Tucker AM. Surgical Management and Outcomes of Intracranial Metastatic Wilms’ Tumor in the Pediatric Population: A Case Series. Childs Nerv Syst. In production.
Lang SS, Kumar NK, Madsen PJ, Gajjar AA, Gajjar E, Resnick AC, Storm PB. Neurotrophic tyrosine receptor kinase fusion in pediatric central nervous system tumors. Cancer Genet. 2022; 262-3: 64-70.
Villavisanis DF, Cho DY, Shakir S, Kalmar CL, Wagner CS, Cheung L, Blum JD, Lang SS, Heuer GG, Madsen PJ, Bartlett SP, Swanson JW, Taylor JA, and Tucker AM. Parietal bone thickness predicts operative transfusion and blood loss in a cohort of patients undergoing spring mediated cranioplasty for nonsyndromic sagittal craniosynostosis. J. Neusorug. Pediatr. 2022; Online ahead of print.
2021
Lang SS, Gajjar A, Tucker AM, Storm PB, Madsen PJ, O’Brien A, Chiotos K, Kilbaugh T, Huh JW. Urgent neurosurgical interventions in the COVID-19 positive pediatric population. World Neurosurg. 2021; 158:196-205.
Buch VP, Kobina MB, James G, Brian P, Madsen PJ, Borja A, Haldar D, Basenfelder P, Yoon J, Schuster J, Chen HC. Development of an Intraoperative Pipeline for Holographic Mixed Reality Visualization During Spinal Fusion Surgery. Surg. Innov. 2021;28(4):427-437.
Foster JB, Griffin C, Rokita JL, Stern A, Brimley C, Rathi K, Lane MV, Buongervino SN, Smith T, Madsen PJ, Martinez D, Wechsler-Reya RJ, Kariko K, Storm PB, Barrett DM, Resnick AC, Maris JM, Bosse KR. Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors. J. Immunother. Cancer. 2022; 10(9): e004450.
Dimentberg R, Kvint S, Madsen P, Glauser G, Choudhri O. Microsurgical Treatment of a Complex Cognard V Tentorial Dural Fistula with Superior Cerebellar Artery Supply. World Neurosurg. 2021; 146:14.
2020
Madsen PJ, Taylor JA, Heuer GG. Commentary: Craniopagus separation, a model for innovation in surgery. Surgery. 2020; epub ahead of print.
Piazza M, Zadnik-Sullivan P, Madsen PJ, Branche M, McShane B, Saylany A, Sharma N, Arlet V, Ozturk A. Proximal junctional kyphosis following Tl 0-pelvis fusion presenting with neurologic compromise: case presentations and review of the literature. Br J Neurosurg. 2020; epub ahead of print.
Proximal junctional kyphosis following Tl 0-pelvis fusion presenting with neurologic compromise: case presentations and review of the literature. Br J Neurosurg. 2020; epub ahead of print.
Flanders TM, Madsen PJ, Pisapia JM, Hudgins ED, Mackell CM, Alexander EE, Moldenhauer JS, Zarnow DM, Flake AW, Adzick NS, Heuer GG. Improved post-operative metrics with modified myofascial closure in fetal myelomeningocele repair. Oper. Neurosurg. 2020; 18(2): 158-65.
Flanders TM, Heuer GG, Madsen PJ, Buch VP, Mackell CM, Alexander E, Moldenhauer JS, Zarnow DM, Flake AW, Adzick NS. Detailed analysis of hydrocephalus and hindbrain herniation after prenatal and postnatal myelomeningocele closure: Report from a single institution. Neurosurg. 2020; 86(5):637-45.
2019
Heuer GG, Madsen PJ, Flanders TM, Kennedy BC, Storm PB, Taylor JA. A multidisciplinary separation of craniopagus twins. NEJM 2019; 380:358-64.
Ramayya AG, Carrasquilla A, Hitti FL, Madsen PJ, Thawani JP, Sinha S, Kvint S, Kung DK, Schuster J. Non-traumatic Rupture of the Ligamentum Flavum with Symptomatic Spontaneous Lumbar Epidural Hematoma: A case report. Interdiscip. Neurosurg. 2019; 16:51-3.Foster JB*, Madsen P J*, Hegde M, Ahmed NM, Cole KA, Maris JM, Resnick AC, Storm PB, Waanders AJ. lmmunotherapy for Pediatric Brain Tumors: Past and Present. Neuro Onco. 2019; 21(10):1226-38.
Goldstein HE, Shao B, Madsen PJ, Hartnett SM, Blount JP, Brockmeyer DL, Campbell RM, Conklin M, Hankinson TC, Heuer GG, Jea AH, Kennedy BC, Tuite GF, Rodriguez L, Feldstein NA, Vitale MG, Anderson RCE. Increased complications without neurological benefit are associated with prophylactic spinal cord untethering prior to scoliosis surgery in children with myelomeningocele. Childs Nerv Syst. 2019; 35(11):2187-94.
Madsen PJ, Buch VP, Douglas JE, Parasher AK, Lerner DK; Alexander E, Workman AD, Palmer JN, Lang SS, Kennedy BC, Vossough A, Adappa ND, Storm PB. Endoscopic Endonasal Resection of Pediatric Craniopharyngioma: Comparison to Open Resection with a Focus on Cerebrovascular and Related Complications. J. Neurosurg. Pediatr. 2019; 24(3):236-45. 2019 JNS Editor's Choice - Tumor.
2018
Madsen PJ, Mallela AN, Hudgins ED, Storm PB, Heuer GG, Stein SC. The Effect and Evolution of Patient Selection on Outcomes in Endoscopic Third Ventriculostomy for Hydrocephalus: A Large-Scale Review of the Literature. J. Neural. Sci. 2018; 385: 185-91.
Stewart L, Sinha S, Madsen PJ, Glaser L, Chen I, Culyba MJ. Spinal epidural abscess caused by Gardnerella vagina/is andPrevotella amnii. Infec. Dis. Clin. Pract. 2018; 26(4):237-9.
2017
Buch VP, Madsen PJ, Vaughan KA, Koch PF, Kung DK, Ozturk AK Rotational vertebrobasilar insufficiency due to compression of a persistent first intersegmental artery: A case report. J. Neurosurg. Spine. 2017; 26(2): 199-202.
2016
Thawani JP, Ramayya AG, Abdullah KG, Hudgins E, Vaughan K, Piazza M, Madsen PJ, Buch V, Grady MS. Resident simulation training in endoscopic endonasal surgery utilizing haptic feedback technology. J. ofClin. Neurosci. 2016; 34:112-16.
2013
Madsen PJ, Lang, SS, Pisapia JM, Storm PB, Hurst RW, Heuer GG. An Institutional Series and Literature Review of Pial Arteriovenous Fistulas in the Pediatric Population. J. Neurosurg. Pediatr. 2013; 12( 4):344-50.
Sievert AJ, Lang SS, Boucher KL, Madsen PJ, Slaunwhite EM, Brewington D, Storm PB, Resnick AC. Paradoxical Activation and RAF Inhibitor Resistance of BRAF Fusions Characterizing Pediatric Astrocytomas. PNAS. 2013; 110(15):5957-62.
2012
Stephen JH, Sievert AJ, Madsen PJ, Judkins AR, Resnick AC, Storm PB, Rushing EJ, and Santi M.: Spinal Cord Ependymomas and Myxopapillary Ependymomas in the First Two Decades of Life: A Clinicopathological and Immunohistochemical Characterization of 19 Cases. J. Neurosurg. Pediatr. 2012; 9(6):646-53.
2010
Popescu DL, Vrabel M, Brausam A, Madsen PJ, Lente G, Fabian I, Ryabov AD, van Eldik R, Collins TJ. Thermodynamic, Electrochemical, High-Pressure Kinetic, and Mechanistic Studies of the Formation of Oxo Fe1v-TAML Species in Water. 2010; Inorg. Chem. 49(24):11439-48.
2008
Shappell NW, Vrabel MA, Madsen PJ, Harrington GE, Billey LO, Hakk H, Larsen GL, Beach ES, Horwitz CP, Ro KS, Hunt PG, Collins TJ. Destruction of Estrogens Using Fe-TAML/Peroxide Catalysis. Environ. Sci. Technol. 2008; 42(2): 1296-300.
Editorials, Reviews, Chapters
2022
Tucker AM, Madsen PJ, Heuer GG. Ventricular Shunts for Hydrocephalus. Fundamentals of Pediatric Surgery. Cham: Springer. 2022.
Madsen PJ, Lang SS, Adappa ND, Palmer JN, Storm PB. Pediatric Pituitary Surgery. Otolaryngology Clinics: Pituitary Surgery. Philadelphia: Elsevier. 2022.
2020
Madsen PJ, Kennedy BC. "Initial Evaluation and Management of Patients with Neurosurgical Devices." Management of the Hi-Tech Patient in Emergency, Acute and Critical Care: A Practical Guide to Managing Patients with Hi-Tech Hardware. 2020; In production.
Madsen PJ, Taylor JA, Heuer GG. "Craniopagus Twins." Youmans and Winn Neurological Surgery. 2020; In preparation.
2018
Madsen PJ, Chen HCI, Chen SS. "Neurosurgical Approaches to the Treatment of Muscle Hyperactivity." Muscle Over-activity in Upper Motor Neuron Syndrome: Assessment and Problem Solving.for Complex Cases. Philadelphia: Elsevier, 2018.