Stephan Kadauke, MD, PhD
Areas of expertise: CAR T cell therapy, Gene therapy, Transfusion medicine, Apheresis, Pediatric transfusion management, Sickle cell disease
Locations: Main Building
About Stephan Kadauke, MD, PhD
Titles
Associate Director, Cell Based Therapy Laboratory
Medical Director, Cell and Gene Therapy Informatics
Attending Physician, Apheresis Service
Assistant Professor of Clinical Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania
Certifications
Clinical Pathology – American Board of Pathology
Blood Banking/Transfusion Medicine – American Board of Pathology
Clinical Informatics – American Board of Pathology
Awards and Honors
2022 Oral Abstract Award, 2022 ASTCT Meeting
2013, Saul Winegrad Award for Outstanding Dissertation, University of Pennsylvania<
2013, Roy G. Williams Award for Meritorious Research in Basic Medical Sciences, University of Pennsylvania
2009-2011, American Heart Association Pre-Doctoral Fellowship, University of Pennsylvania
2005-2009, Benjamin and Mary Siddons Measey Foundation Fellowship, University of Pennsylvania
2004, Phi Beta Kappa - Early Induction for Top 2% of Graduating Class, Columbia University
Leadership and Memberships
2017-Present, AABB
2019-Present, International Society for Cellular Therapy (ISCT)
2020-Present, R/Medicine (Chair of the Organizing Committee (2020-2022))
2014-2018, The Sumaira Foundation for Neuromyelitis Optica (Member of the Medical Advisory Board)
2018-Present, American Society of Apheresis (ASFA)
2019-Present, American Association for Clinical Chemistry (AACC)
2019-Present, Association for Pathology Informatics (API)
2019-Present, College of American Pathologists
2020-Present, American Society for Transplantation and Cellular Therapy (ASTCT)
2021-Present, American Medical Informatics Association (AMIA)
Editorial and Academic Positions
Editorial Positions
2017-present, Peer Reviewer, Transfusion Medicine Reviews
2019-present, Peer Reviewer, Transfusion
2020-present, Peer Reviewer, R Journal
2021-present, Peer Reviewer, Journal of Mass Spectrometry and Advances in the Clinical Lab
2022-Present, Peer Reviewer, Cytotherapy
2022-present, Peer Reviewer, Journal of Applied Laboratory Medicine
Education & training
Graduate Degree
PhD in Cell and Molecular Biology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Medical Degree
MD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Residency
Clinical Pathology - Massachusetts General Hospital, Boston, MA (Chief Resident)
Fellowship
Transfusion Medicine - Harvard Medical School, Cambridge, MA
Publications
PubMed
Publications
2024
Lescoat A, Ghosh M, Kadauke S, Khanna D. Innovative cell therapies for systemic sclerosis: available evidence and new perspectives. Expert Rev Clin Immunol. 2024 Sep 24;:1-15. doi: 10.1080/1744666X.2024.2402494. [Epub ahead of print] Review. PubMed PMID: 39279565.
Wyatt KD, Alexander N, Hills GD, Liang WH, Kadauke S, Volchenboum SL, Mian A, Phillips CA. Making sense of artificial intelligence and large language models-including ChatGPT-in pediatric hematology/oncology. Pediatr Blood Cancer. 2024 Sep;71(9):e31143. doi: 10.1002/pbc.31143. Epub 2024 Jun 26. Review. PubMed PMID: 38924670.
Myers RM, Devine K, Li Y, Lawrence S, Leahy AB, Liu H, Vernau L, Callahan C, Baniewicz D, Kadauke S, McGuire R, Wertheim GB, Kulikovskaya I, Gonzalez VE, Fraietta JA, DiNofia AM, Hunger SP, Rheingold SR, Aplenc R, June CH, Grupp SA, Wray L, Maude SL. Reinfusion of CD19 CAR T cells for relapse prevention and treatment in children with acute lymphoblastic leukemia. Blood Adv. 2024 May 14;8(9):2182-2192. doi: 10.1182/bloodadvances.2024012885. PubMed PMID: 38386999; PubMed Central PMCID: PMC11061218.
2023
Al-Riyami AZ, Maryamchik E, Hanna RS, Pashmineh Azar AR, Zheng X, Choudhari S, Finn C, Giacobbe N, Machietto R, Rieser R, Ghasemi Tahrir F, Zhang X, Kadauke S, Wang Y. A machine-learning model that incorporates CD45 surface expression predicts hematopoietic progenitor cell recovery after freeze-thaw. Cytotherapy. 2023 Oct;25(10):1048-1056. doi: 10.1016/j.jcyt.2023.05.007. Epub 2023 Jun 12. PubMed PMID: 37318396.
Kadauke S, Bonamino MH, Levine BL, Harrison R, Karnieli O. In-Hospital Manufacturing of Cellular Therapies Using Automated Systems. Clin Chem. 2023 Sep 1;69(9):954-960. doi: 10.1093/clinchem/hvad102. PubMed PMID: 37478367.
Machietto R, Giacobbe N, Perazzelli J, Hofmann TJ, Barz Leahy A, Grupp SA, Wang Y, Kadauke S. Chimeric Antigen Receptor T Cell Manufacturing on an Automated Cell Processor. J Vis Exp. 2023 Aug 18;(198). doi: 10.3791/65488. PubMed PMID: 37607096.
Chu Y, Milner J, Lamb M, Maryamchik E, Rigot O, Ayello J, Harrison L, Shaw R, Behbehani GK, Mardis ER, Miller K, Prakruthi Rao Venkata L, Chang H, Lee D, Rosenthal E, Kadauke S, Bunin N, Talano JA, Johnson B, Wang Y, Cairo MS. Manufacture and Characterization of Good Manufacturing Practice-Compliant SARS-COV-2 Cytotoxic T Lymphocytes. J Infect Dis. 2023 Mar 28;227(6):788-799. doi: 10.1093/infdis/jiac500. PubMed PMID: 36583990.
Anderson DS, Hanna RS, Azar ARP, Collier V, Hankins P, Loudon B, Olson TS, Grupp SA, Phillips CA, Kadauke S. Automation of Hematopoietic Cell Transplantation Outcomes Reporting Leads to Dramatic Reduction in Errors Reported to Real-World Data Registry. Transplant Cell Ther. 2023 Mar;29(3):207.e1-207.e5. doi: 10.1016/j.jtct.2022.12.026. Epub 2023 Jan 5. PubMed PMID: 36610491.
Newman H, Li Y, Liu H, Myers RM, Tam V, DiNofia A, Wray L, Rheingold SR, Callahan C, White C, Baniewicz D, Winestone LE, Kadauke S, Diorio C, June CH, Getz KD, Aplenc R, Teachey DT, Maude SL, Grupp SA, Bona K, Leahy AB. Impact of poverty and neighborhood opportunity on outcomes for children treated with CD19-directed CAR T-cell therapy. Blood. 2023 Feb 9;141(6):609-619. doi: 10.1182/blood.2022017866. PubMed PMID: 36351239; PubMed Central PMCID: PMC9979709.
Kadauke S. Should We Teach Data Science to Laboratorians-in-Training?. J Appl Lab Med. 2023 Jan 4;8(1):208-212. doi: 10.1093/jalm/jfac107. PubMed PMID: 36610425.
2022
Leahy AB, Li Y, Talano JA, Elgarten CW, Seif AE, Wang Y, Johnson B, Monos DS, Kadauke S, Olson TS, Freedman J, Wray L, Grupp SA, Bunin N. Unrelated donor α/β T cell- and B cell-depleted HSCT for the treatment of pediatric acute leukemia. Blood Adv. 2022 Feb 22;6(4):1175-1185. doi: 10.1182/bloodadvances.2021005492. PubMed PMID: 34872106; PubMed Central PMCID: PMC8864664.
2021
Uter S, An HH, Linder GE, Kadauke S, Sesok-Pizzini D, Kim HC, Friedman DF, Chou ST. Measures to reduce red cell use in patients with sickle cell disease requiring red cell exchange during a blood shortage. Blood Adv. 2021 Jun 22;5(12):2586-2592. doi: 10.1182/bloodadvances.2021004395. PubMed PMID: 34152394; PubMed Central PMCID: PMC8270657.
Kadauke S, Myers RM, Li Y, Aplenc R, Baniewicz D, Barrett DM, Barz Leahy A, Callahan C, Dolan JG, Fitzgerald JC, Gladney W, Lacey SF, Liu H, Maude SL, McGuire R, Motley LS, Teachey DT, Wertheim GB, Wray L, DiNofia AM, Grupp SA. Risk-Adapted Preemptive Tocilizumab to Prevent Severe Cytokine Release Syndrome After CTL019 for Pediatric B-Cell Acute Lymphoblastic Leukemia: A Prospective Clinical Trial. J Clin Oncol. 2021 Mar 10;39(8):920-930. doi: 10.1200/JCO.20.02477. Epub 2021 Jan 8. PubMed PMID: 33417474; PubMed Central PMCID: PMC8462622.
2020
Maryamchik E, Gallagher KME, Preffer FI, Kadauke S, Maus MV. New directions in chimeric antigen receptor T cell [CAR-T] therapy and related flow cytometry. Cytometry B Clin Cytom. 2020 Jul;98(4):299-327. doi: 10.1002/cyto.b.21880. Epub 2020 Apr 30. Review. PubMed PMID: 32352629.
Zhang ML, Guo AX, Kadauke S, Dighe AS, Baron JM, Sohani AR. Machine Learning Models Improve the Diagnostic Yield of Peripheral Blood Flow Cytometry. Am J Clin Pathol. 2020 Jan 2;153(2):235-242. doi: 10.1093/ajcp/aqz150. PubMed PMID: 31603184.
2019
Belizaire R, Mack J, Kadauke S, Kim Y, Saidman S, Makar RS. Red blood cell alloantibodies are associated with increased alloimmunization against human leukocyte antigens. Transfusion. 2019 Jul;59(7):2256-2263. doi: 10.1111/trf.15306. Epub 2019 Apr 13. PubMed PMID: 30980544.
2017
Dhaliwal G, Mojtahed A, Fogerty AE, Kadauke S, Mack JP. Case 36-2017. A 30-Year-Old Man with Fatigue, Rash, Anemia, and Thrombocytopenia. N Engl J Med. 2017 Nov 23;377(21):2074-2083. doi: 10.1056/NEJMcpc1710565. PubMed PMID: 29166229.
2016
Kadauke S, Hiemenz MC, Lieberman DB, Roth DB, Zhao J, Watt CD, Daber RD, Morrissette JJ: Building a robust tumor profiling program: synergy between next-generation sequencing and targeted single-gene testing. PLOS One 11(4): e:0152851, April 2016 Notes: SK and MCH contributed equally.
2015
Stonestrom AJ, Hsu SC, Jahn KS, Huang P, Keller CA, Giardine BM, Kadauke S, Campbell AE, Evans P, Hardison RC, Blobel GA: Functions of BET proteins in erythroid gene expression. Blood 125(18): 2825-2834, October 2015.
2012
Kadauke S, Udugama MI, Pawlicki JM, Achtman JC, Jain DP, Cheng Y, Hardison RC, Blobel GA: Tissue-specific mitotic bookmarking by hematopoietic transcription factor GATA1. Cell 150(4): 725-737, August 2012 Notes: Featured in Niemitz E (2012). Transcription programs and cell division. Nature Genetics (10)44:1079.
2011
Lamonica JM, Kadauke S, Deng W, Campbell AE, Gamsjaeger R, Wang H, Cheng Y, Billin AN, Hardison RC, Mackay JP, Blobel GA: Bromodomain protein Brd3 associates with acetylated GATA1 to promote its chromatin occupancy at erythroid target genes. Proceedings of the National Academy of Sciences of the United States of America 108(22): E159-E168, May 2011 Notes: Elected by the Faculty of 1000 into top 2% of articles in biology and medicine (2011). SK and WD contributed equally.
2010
Blobel GA, Kadauke S, Wang E, Lau AW, Zuber J, Chou MM, Vakoc CR: A reconfigured pattern of MLL occupancy with mitotic chromatin promotes rapid transcriptional reactivation following mitotic exit. Molecular Cell 36(6): 970-983, December 2009 Notes: Featured in Dressler GR (2010). Turning the page on epigenetic bookmarks. Developmental Cell 18(1):4-5.
Abstracts (includes Posters and Scientific Presentations)
2018
Hawkins J, O'Doherty U, Kadauke S: A proposal to evaluate the effect of gamma irradiation on the survival of transfused red cells in sickle cell disease patients. American Society for Apheresis 2018 Annual Meeting, Chicago, IL April 2018 Notes: Poster Presentation.
Kadauke S: Teaching reproducible data analysis to medical doctors. rstudio::conf 2018, San Diego, CA February 2018 Notes: Electronic Poster Presentation.
Lectures by Invitation
2018
Kadauke S. "Breaking up with Excel: a newbie's introduction to the R statistical programming language", Mass Spectrometry: Applications to the Clinical Lab 10th Annual Conference, Palm Springs, CA. Jan, 2018.
Kadauke S. "Advances in the diagnosis and management of thrombotic thrombocytopenic purpura", Weill-Cornell Medicine, New York, NY. Jan, 2018.
2017
Kadauke S. "Advances in the diagnosis and management of thrombotic thrombocytopenic purpura", Memorial Sloan Kettering Cancer Center, New York, NY. Dec, 2017.
Kadauke S. "Advances in the diagnosis and management of thrombotic thrombocytopenic purpura", Stanford Blood Center, Palo Alto, CA. Dec, 2017.
Kadauke S. "Advances in the diagnosis and management of thrombotic thrombocytopenic purpura", University of Maryland Medical Center, Baltimore, MD. Nov, 2017.
Kadauke S. "Advances in the diagnosis and management of thrombotic thrombocytopenic purpura", Children's Hospital of Philadelphia, Philadelphia, PA. Mar, 2017.
Editorials, Reviews, Chapters
2017
Kadauke S: Utilization management of blood derivatives. Utilization management in the clinical laboratory and other ancillary services. Lewandroski L, Sluss PM (eds.). Springer International Publishing, Cham, Switzerland, Page: 135-140, December 2017.