Research Studies

Solid Tumor Program Research Studies

Find research studies available to children cared for by the Solid Tumor Program team.
Existing patients or family members
New patients, referrals and second opinions

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Clinical trial
Children (19)
Adults (18)
MRI/Imaging Studies (2)

Clinical Trial Phases
Phase I (11)
Phase II (14)
N/A (1)

Recruitment Status
Recruiting (17)
Non-recruiting (2)

Related conditions
Central Nervous System (CNS) Germ Cell Tumors (6)
Ewing sarcoma (5)
Thyroid Cancer in Children (4)
Neuroblastoma (3)
Osteosarcoma (bone cancer in children) (3)
Medullary Thyroid Cancer (2)
Soft tissue sarcomas (2)
Desmoid tumors (1)
Hepatoblastoma (liver cancer) (1)
Non-Hodgkin Lymphoma in Children (1)
Wilms Tumor (Kidney Tumor) (1)

Related Specialties and Programs
Solid Tumor Program (19)
Cancer Center (17)
Center for Precision Medicine for High-Risk Pediatric Cancer (13)
Cancer Immunotherapy Program (1)
Developmental Therapeutics Program (1)
Leukemia and Lymphoma Program (1)

Specialty
Oncology (19)

Afamitresgene Autoleucel in Pediatric Subjects with MAGE-A4 Positive Tumors
This study involves an investigational cellular therapy called Afamitresgene Autoleucel. The overall goal of this study is to find out how safe and effective this cellular therapy is in treating people that have been diagnosed with synovial sarcoma, malignant peripheral nerve sheath tumors (MPNST), neuroblastoma or osteosarcoma that has grown or returned after being treated.   

Phase: Phase I, Phase II

Actively recruiting: Yes

Category: Adults, Children

Conditions: Neuroblastoma

BA3011 for advanced solid tumors

This study involves taking a study drug called BA3011. Theoverall goal of this study is to see if BA3011 is a possible treatment forpatients with sarcoma.

Phase: Phase I, Phase II

Actively recruiting: No

Category: Adults, Children

Cabo/Ifos in Ewing Sarcoma and Osteosarcoma (CaIRS trial)
This study enrolls patients between 5 and 40 years of age with a diagnosis of Ewing sarcoma (including Ewing-like sarcoma) or osteosarcoma that has progressed on or relapsed after upfront initial therapy. The purpose of this study is to find the best dose of a drug called cabozantinib (“the study drug”) to give to patients in combination with a routine chemotherapy drug called ifosfamide. 

Phase: Phase I

Actively recruiting: Yes

Category: Adults, Children

Conditions: Ewing sarcoma, Osteosarcoma (bone cancer in children)

GD2CART for Osteosarcoma or Neuroblastoma
This study enrolls patients that have been diagnosed with osteosarcoma or neuroblastoma that has come back (relapsed) or has not responded to standard treatments (refractory). This study involves an investigational cellular therapy called GD2CART. The study will be testing different doses of the study drug to find the safest dose.

Phase: Phase I

Actively recruiting: Yes

Category: Adults, Children

Conditions: Neuroblastoma, Osteosarcoma (bone cancer in children)

INBRX-109 in Ewing Sarcoma and Gastrointestinal Stromal Tumor (GIST)

This study involves taking a study drug called INBRX-109. The overall goal of the study is to find out how safe and effective the study drug is in treating people that have been diagnosed with advanced or metastatic Ewing sarcoma or SDH-deficient solid tumor/Gastrointestinal Stromal Tumor (GIST).

Phase: Phase I

Actively recruiting: Yes

Category: Adults, Children

Conditions: Ewing sarcoma, Central Nervous System (CNS) Germ Cell Tumors

Larotrectinib RAI Thyroid (LANTERN)
This study enrolls patients with newly diagnosed differentiated thyroid cancer (papillary thyroid cancer or follicular thyroid cancer) that has spread to the lungs and has a genetic mutation called and NTRK fusion. The study involves taking a study drug called larotrectinib for approximately 6 months prior to receiving radioiodine therapy (RAI). The overall goal of this study is to find out if taking the study drug before RAI works better than receiving RAI alone (the usual standard of care treatment). 

Phase: Phase II

Actively recruiting: Yes

Category: Adults, Children, MRI/Imaging Studies

Conditions: Thyroid Cancer in Children

Lurbinectedin in Ewing Sarcoma
This study involves taking a study drug called lurbinectedin. The overall goal of this study is to see if different doses of lurbinectedin are safe and effective at treating children and young adults with recurrent or relapsed solid tumors, including Ewing Sarcoma.

Phase: Phase I, Phase II

Actively recruiting: Yes

Category: Adults, Children

Conditions: Central Nervous System (CNS) Germ Cell Tumors, Ewing sarcoma

Lutathera in Somatostatin Neuroendocrine Tumors

This study involves taking a study drug called Lutathera.The overall goal of this study is to see if Lutathera is safe in adolescentsubjects with either a gastroenteropancreatic neuroendocrine tumor (GEP-NET),or a pheochromocytoma and/or paraganglioma (PPGL). This study will also look atthe levels of radioactivity after Lutathera administration.

Phase: Phase II

Actively recruiting: Yes

Category: Children

ON-TRK
The goal of this observational study is to describe the safety and effectiveness of larotrectinib in patients with locally advanced or metastatic TRK fusion cancer for whom a decision to treat with larotrectinib has been made before enrollment. This study will enroll participants with any tumors harboring the NTRK gene fusion including Soft Tissue Sarcomas, Central Nervous System, Melanoma, and Thyroid cancers.

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children

Conditions: Central Nervous System (CNS) Germ Cell Tumors, Soft tissue sarcomas, Thyroid Cancer in Children

Palbociclib, Irinotecan, and Temozolomide in Ewing Sarcoma
The purpose of the Phase 2 portion of this study is to evaluate the safety and efficacy of the study drug called palbociclib when given in combination with two other drugs (temozolomide and irinotecan) in patients with Ewing sarcoma and when given in combination with topotecan and cyclophosphamide in patients with neuroblastoma.

Phase: Phase II

Actively recruiting: Yes

Category: Adults, Children

Conditions: Neuroblastoma