Larotrectinib RAI Thyroid (LANTERN)

Larotrectinib RAI Thyroid (LANTERN)

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This study is now recruiting. Learn more about enrolling here.

Description
This study enrolls patients with newly diagnosed differentiated thyroid cancer (papillary thyroid cancer or follicular thyroid cancer) that has spread to the lungs and has a genetic mutation called and NTRK fusion. The study involves taking a study drug called larotrectinib for approximately 6 months prior to receiving radioiodine therapy (RAI). The overall goal of this study is to find out if taking the study drug before RAI works better than receiving RAI alone (the usual standard of care treatment). 

What to expect
Participants in the research will:
  • Receive a study drug called Larotrectinib
  • Complete frequent clinic visits at CHOP
  • Possibly delay standard of care RAI therapy
  • Have periodic imaging performed to evaluate response to treatment
Those who agree to participate in the optional imaging sub-study will:
  • Have an extra Whole Body Scan (WBS)
  • Consume a low iodine diet for 7-14 days before the WBS scan
  • Receive a drug called Thyrogen and receive a low dose of radioactive sodium iodine before the WBS scan

Related specialties
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