Researchers from Children’s Hospital of Philadelphia (CHOP) confirmed that “mini-intestines” generated from patient tissue samples and grown in a lab can accurately replicate certain features of Crohn’s disease, which will allow them to study the epithelium, the thin layer of cells lining the intestine, that is broken down in patients with inflammatory bowel disease. 

Researchers from CHOP and Penn are working to perfect 3D models of GI disease and create more personalized treatments for patients.

Alongside conducting critical research, many faculty members at Children’s Hospital of Philadelphia play dual roles as mentors to postdocs and fellows in their labs, imparting scientific knowledge about their respective fields, sharing career guidance, and creating an environment conducive to building the next generation of successful scientists.

In a new partnership between the Office of Academic Training and Outreach Programs with Central High School of the School District of Philadelphia, three students selected by their teachers conducted research at Children’s Hospital of Philadelphia Research Institute.

The Emerging Innovators Collaborative Research program is organized by the Office of Academic Training and Outreach Programs (ATOP). The programs recognize exceptional non-faculty researchers-in-training and research staff who contributed to a collaborative project, producing high-impact research.

Bench-to-bedside research supports GI innovation at CHOP.

Personalized therapeutic approaches for children with eosinophilic esophagitis are gaining ground at CHOP.

The diagnosis and treatment of eosinophilic esophagitis is often very challenging, requiring management from multiple subspecialties. 

New research from CHOP has pinpointed how one particular protein may be implicated in how epithelial cells respond to stress as a result of IBD.