Research Studies

Division of Pulmonary and Sleep Medicine Research Studies

Find research studies available to children cared for by the Division of Pulmonary and Sleep Medicine team.
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Clinical trial
Children (4)
Adults (2)
Healthy Controls (2)
MRI/Imaging Studies (2)

Clinical Trial Phases
Phase II (1)
N/A (3)

Recruitment Status
Recruiting (3)
Non-recruiting (1)

Related Specialties and Programs
Division of Pulmonary and Sleep Medicine (4)
Sleep Center (1)

Specialty
Pulmonology (4)

Down Syndrome and Sleep Apnea Study (DOSA)
This research study is being conducted to look at oxygen as a treatment of obstructive sleep apnea (OSA) in children with Down syndrome. The main reason for the study is to show how 6 months of oxygen treatment while sleeping affects the participants sleep, quality of life, breathing, heart and if it makes the participant feel better.

Phase: Phase II

Actively recruiting: Yes

Category: Children

Melatonin, Sleep, and Mental Health

The purpose of this research study is to see if melatonin improves sleep and the sleep-wake patterns (also known as circadian rhythm) in children, teenagers, and young adults (ages 11-30) with at-risk symptoms. Melatonin is naturally produced in the brain and controls sleep-wake patterns. At-risk symptoms can be feeling like you do not want to do be around other people as much, difficulties with focus, and having beliefs that most people around you don’t have. At-risk symptoms can also be experiences like having jumbled up thoughts, your mind playing tricks on you, or seeing or hearing things that are not there. To see if melatonin changes sleep in youth with at-risk symptoms, we are giving some youth with at-risk symptoms a melatonin pill and some a placebo (a pill without any medication in it) for 6 months.

Phase: N/A

Actively recruiting: No

Category: Adults, Children, Healthy Controls

Non-Invasively Assessing Lung Ventilation in Pediatrics
We are looking at how infants and young children breathe in different positions. This will help us understand how children with different types of lung hypoplasia breathe and how the lung changes and grows. To do this, we will measure regional lung ventilation by electrical impedance tomography (EIT) in three positions: lying on the back, right- and left-side in children with pulmonary hypoplasia and in healthy children without lung disease. EIT has been well established as a safe, non-invasive, radiation free method of assessing regional lung ventilation. There is no compensation available for this study.

Phase: N/A

Actively recruiting: Yes

Category: Children, Healthy Controls, MRI/Imaging Studies

Sleep Apnea in People with Beckwith-Wiedemann Syndrome
Children and adults with Beckwith-Wiedemann syndrome may be at increased risk for sleep apnea than other children. This risk may be due to a larger tongue size, but currently it is not known how to predict who need to be evaluated for sleep apnea. Some people with Beckwith-Wiedemann syndrome have tongue reduction surgery, but the effect of this procedure on sleep apnea is not known. This study seeks to understand how the upper airway anatomy contributes to sleep apnea in people with Beckwith-Wiedemann syndrome, including after tongue reduction surgery in people who have that procedure. The study includes a physical exam, medical record review (including surgical history), and upper airway MRI. For those participants who have not had a clinical sleep study, one will be done as part of this study.

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children, MRI/Imaging Studies