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Research Studies

Division of Nephrology Research Studies

Find research studies available to children cared for by the Division of Nephrology team.

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Dialysis unit (main hospital)

Eligible age

ARPKD/HRFD Database

CHOP has established a research database of data and biological samples of people who have autosomal polycystic kidney disease (ARPKD) or another hepato/renal fibrocystic disease (HRFD). The purpose is to try to learn more about the causes of these diseases. We will collect data from participants' medical records to contribute to the database. Optional blood/saliva or tissue sample may also be collected. Visit arpkdb.org to download the consent or call the CHOP Research Coordinator, Jasmine Jaber at jaberj2@chop.edu.

Phase: N/A

Actively recruiting: Yes

Category: Children, One-Time Visit Studies, Remote (Online / Phone Call Only) Studies

Conditions: Polycystic Kidney Disease

Chronic Kidney Disease in Children (CKiD) Study

CKiD is an important research study looking at the health of children, teenagers, and young adults who have kidney problems. This research is being done to identify what factors help kidneys stay healthy, and also to see how kidney problems affect health and well-being. Teenagers and young adults 16-22 years old who have been diagnosed with chronic kidney disease (CKD) may be eligible to join the study. The CKiD study has enrolled approximately 1100 children and teenagers across North America since the study began in 2003. Our goal now is to enroll teenagers and young adults in the study. By doing this we can have a better idea of what happens to kidney function and overall health as someone with childhood chronic kidney disease grows up. This will help provide us with a more complete picture of CKD from childhood through adulthood.

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children

Conditions: Chronic Kidney Disease (CKD)

CureGN Study

Cure Glomerulonephropathy Network (CureGN) is a multi-year study of 2,400 children and adults with four rare glomerular (kidney) diseases at over 50 centers in the US, Canada, and Italy. The purpose of CureGN is to create a patient research network to learn about four major causes of glomerular disease : 1. Minimal Change Disease (MCD) 2. Focal Segmental Glomerulosclerosis (FSGS) 3. Membranous Nephropathy (MN) 4. IgA Nephropathy (IgAN)

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children

Conditions: Glomerulonephritis in Children

Genomics of Nephrotic Syndrome

For this study, we are studying the relationship between variations in the genes of the immune system called HLA and how they relate to:

  1. The risk of developing nephrotic syndrome
  2. The response to treatment of nephrotic syndrome and
  3. The risk of recurrence of nephrotic syndrome following kidney transplantation.
Participants will be asked to provide a one time blood sample for DNA testing and information about their health will be collected.
To be eligible, participants must have:
  1. Clinical diagnosis of nephrotic syndrome
  2. Biopsy proven diagnosis of FSGS or MCD and,
  3. History of living or deceased donor kidney transplantation

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children, One-Time Visit Studies

Conditions: Nephrotic Syndrome in Children

IMPAKT

In this study, we are developing new magnetic resonance imaging (MRI) and ultrasound methods to determine if it is effective in diagnosing complication in kidney transplant patients. Participants in this study will involve patients that have had a kidney transplant and are scheduled for a kidney biopsy. The study will also involve a comparison group of healthy individuals that have no history of kidney conditions. Study procedures will include a review of medical history and medications, MRI scan and ultrasound of the abdomen and blood/ urine test.

Phase: N/A

Actively recruiting: Yes

Category: Adults, Children, Healthy Controls, MRI/Imaging Studies

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