CHOP has established a research database of data and biological samples of people who have autosomal polycystic kidney disease (ARPKD) or another hepato/renal fibrocystic disease (HRFD). The purpose is to try to learn more about the causes of these diseases. We will collect data from participants' medical records to contribute to the database. Optional blood/saliva or tissue sample may also be collected. Visit arpkdb.org to download the consent or call the CHOP Research Coordinator, Jasmine Jaber at jaberj2@chop.edu.

For this study, we are studying the relationship between variations in the genes of the immune system called HLA and how they relate to:

1. The risk of developing nephrotic syndrome
2. The response to treatment of nephrotic syndrome and
3. The risk of recurrence of nephrotic syndrome following kidney transplantation.

1. Clinical diagnosis of nephrotic syndrome
2. Biopsy proven diagnosis of FSGS or MCD and,
3. History of living or deceased donor kidney transplantation