Life expectancy for a child with Trisomy 21 (Down syndrome) has increased dramatically in the past 50 years as cardiac surgery and post-surgical care have improved. Today, clinicians have guidelines to help identify, understand and address relevant medical issues.

Refusal behaviors need to be interpreted differently in individuals with Trisomy 21 (Down syndrome). Often, these behaviors signal frustration or lack of understanding and can provide important clues about how to best assist the individual's development.

CHOP and Penn Medicine experts are refining their diagnostic tools to predict which patients are more likely to respond to drugs called ALK inhibitors that target such mutations, setting the stage for a phase 3 clinical trial.

CHOP announces the selection of Stephen P. Hunger, MD, a nationally prominent specialist in children’s cancer, as its new chief of the Division of Oncology and the director of the Center for Childhood Cancer Research.

Nothing throws a monkey wrench into your day like a child waking up feeling sick. But before you cancel your meetings and call out for carpool assistance, know that not every cough and sniffle means your child should stay home from school.

CHOP and Temple share a $4.3 million NIH grant to explore new tools to eradicate HIV lurking in brain cells despite current antiviral treatments.

Subtle changes in mitochondria, our cells’ power plants, may trigger a broad range of common diseases, says a pioneering CHOP scientist.

Rescued from Haiti with numerous health problems, Bryon, 3, was fortunate to end up with a loving family living right in CHOP’s backyard.

Music therapist Mike Mahoney, MA, MT-BC, offers up instruments from his cart: maracas, a drum, a keyboard. The children at the Alex Scott Day Hospital are eager to sing and play music.

Sedation is common before procedures and scans such as an MRI, and as a child life specialist in Radiology’s Sedation Unit, Melanie Hoynoski is there to prepare kids on what to expect.