The primary objective of this study is to collect biospecimens to conduct protein biomarker studies in patients with heart failure requiring advanced therapies such as OHT and VAD. A dedicated heart failure biospecimen repository will allow the Cardiac Center to be at the forefront of molecular sub-phenotyping to improve mechanistic understanding, clinical care, and trial design.

The primary goal of this research study is to learn if patients with autosomal recessive polycystic kidney disease (ARPKD) are at risk for brain aneurysms or cardiovascular abnormalities.Participants in this study will involve patients that have a clinical diagnosis of ARPKD.The study will also involve a comparison group of healthy individuals that have no history of kidney or cardiac conditions.

This pilot study is investigating the feasibility of a prospective biomarker study in the CICU by measuring enrollment of subjects, as well as the looking at outcomes. The goal of this study is to risk stratify neonates with congenital heart disease requiring neonatal cardiopulmonary bypass for poor outcomes in order to appropriately tailor medical care and for possible future trials.