VOCAL Trial

VOCAL Trial

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This study is now recruiting. Learn more about enrolling here.

Description
This is a study to measure the effectiveness of the medication voclosporin compared to placebo in adolescent patients with active lupus nephritis. Volcosporin is an outpatient, oral medication.

Eligibility and criteria
IRB Number:
23-021424
Eligible age range:
12 years - 18 years
Clinical trial phase:
Phase III
Official title:
A Double-Blind, Placebo-Controlled, Dose Escalation Study to Assess the Efficacy, Safety and Pharmacokinetics of Voclosporin in Adolescents with Lupus Nephritis

What to expect
Along with taking voclosporin, participants will also:
  • Provide blood and urine samples
  • Complete physical exams
  • Complete an ECG (electrocardiogram) 
  • Complete questionnaires and a disease activity assessment
  • Take MMF (mycophenolate mofetil)/oral corticosteroids 
  • Have methylprednisolone administration
  • Some people will take a placebo
  • Have medical record review(s)
Participation will last for 32 weeks and will involve 14 study visits.

Related specialties
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