LEOPARDS Linking Endotypes and Outcomes in Pediatric Acute Respiratory Distress Syndrome

The study goal is to risk stratify pediatric (Acute Respiratory Distress Syndrome) ARDS patients and to identify sub-phenotypes with shared biology in order to appropriately target therapies in future trials. Specifically, the study aims to: Aim 1: Validate and refine PARDSEVERE, a published protein biomarker-based pediatric ARDS risk stratification tool Aim 2: Stratify pediatric ARDS into sub-phenotypes using a known 100-gene expression-based classifier to group subjects according to shared underlying biology Aim 3: Identify de novo sub-phenotypes in pediatric ARDS using biomarkers and whole genome transcriptomics of peripheral blood