Robert N. Baldassano, MD
Areas of expertise: Crohn's disease, Diet and inflammatory bowel disease, Ulcerative colitis
Locations: Main Building
About Robert N. Baldassano, MD
Robert N. Baldassano, MD, is a board-certified pediatric gastroenterologist and co-director of the Center for Pediatric Inflammatory Bowel Disease at Children’s Hospital of Philadelphia. He specializes in diagnosing and treating children with Crohn’s disease and ulcerative colitis, and is actively researching new treatments for these gastrointestinal disorders.
Dr. Baldassano became a doctor and chose gastroenterology as a specialty for a very personal reason: He has Crohn’s disease. “I was in my 20s and working as a systems analyst when I was diagnosed. I felt drawn to medicine as a career. I thought maybe I’d be able to help create new therapies or cures that could help others, as well as myself.”
His philosophy of care is simple: “Every child deserves a perfect life. I try to make that happen.”
Because of his own 30-year battle with Crohn’s disease, Dr. Baldassano understands the challenges of symptom flare-ups, repeated endoscopies, and frequent hospitalizations.
“I guess I have empathy for my patients. I’ve lived their lives,” Dr. Baldassano says. “I understand their struggles and I’m working to improve treatment for all.”
Education and experience
Dr. Baldassano earned his bachelor’s degree from the State University of New York (SUNY) at Albany, and his medical degree from the College of Medicine at SUNY Health Science Center in Brooklyn, NY. He completed his pediatric residency training at The Children’s Hospital of Philadelphia, then served two-year terms as a clinical fellow, then a research fellow in gastroenterology at CHOP.
After his intensive training, Dr. Baldassano worked at Geisinger Medical Center in Danville, PA, for several years. In 1996, he returned to CHOP as a senior pediatric gastroenterologist and director of CHOP’s Center for Pediatric Inflammatory Bowel Disease.
Since then, Dr. Baldassano has continued his clinical and research work with children who have inflammatory bowel diseases. He served as associate medical director of CHOP’s Clinical Research Institute for five years.
Currently, Dr. Baldassano also holds the titles of Colman Family Chair in Pediatric Inflammatory Bowel Disease, medical director of the CHOP Specialty Care Center in Abington, PA, and co-director of the Penn/CHOP Microbiome Program.
Dr. Baldassano is actively involved in numerous professional and scientific societies including the Crohn’s and Colitis Foundation of America, the American Gastroenterological Association and the IBD Family Research Council. He has published hundreds of papers, presented at regional, national and international meetings, and received dozens of awards.
Research
In addition to his clinical work, Dr. Baldassano oversees a large team of researchers at CHOP. The team has more than 30 ongoing studies. Doctors and scientists are working together to translate discoveries in the laboratory into direct patient care for children.
One promising area of current research is investigating the intestinal microbiomes of children with inflammatory bowel diseases.
“Intestinal diseases are driven by the organisms that live inside us, and our diet — what we eat — greatly influences that,” Dr. Baldassano said. “We’re studying how diet changes can alter an individual’s microbiome so that it promotes health, instead of disease.”
Titles
Director, CHOP Microbiome Center
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Certifications
Diplomate – National Board of Medical Examiners (NBME)
Pediatric Gastroenterology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Awards and Honors
2021, Top Doctors Digital Guide, Pediatric Gastroenterology, Castle Connolly
2018, The Academy of Master Clinicians, Penn Medicine
2017, United to Care & Cure Award 2017, Crohn's & Colitis Foundation (CCF)
2013 & 2014, 2018, 2020-2023, Philadelphia Magazine's Top Doctors in Gastroenterology, Hepatology and Nutrition
2013, Fellows Faculty Honor Roll, Children's Hospital of Philadelphia
2012, Blockley-Osler Award
2003, Pediatric Resident Teaching Honor Roll
2003-2008, 2019, Best Doctors in America
2003-2012, 2014 America's Top Doctors
2002, Best Pediatricians in America, Best Doctors List
2002, Physician of the Year Award
2001, Doctors Who Make a Difference, Child Magazine
2001, David Cornfeld Bedside Teaching Award
2001-2013, Top Doctors for Kids, Philadelphia Magazine,
1993, Education Award for Excellence in Inflammatory Bowel Disease Teaching, Research and Clinical Care
1992, Golden Apple Award for Excellence in Pediatric Resident Teaching
1990-1993, Crohn's and Colitis Foundation of American Research Fellowship Award
1988, Pediatric Housestaff Humanitarian Award
1988, NIH Research Fellowship Award
1984-1985, Honor Scholarship, SUNY Health Science Center
1983-1987, Alpha Omega Alpha, SUNY Health Science Center
1975-1977, Mathematical Association of American, Mathematics Honor Society
1975-1977, Summa Cum Laude-State University of New York
1975-1977, Phi Beta Kappa-State University of New York
1975-1977, Sigma Phi Sigma, Physics Honor Society-State University of New York
Leadership and Memberships
Memberships in professional organizations
International
2004-present, World Congress of Pediatric Gastroenterology, Hepatology and Nutrition
National
1998-present, American Gastroenterological Association
1991-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
- 2004-present, Inflammatory Bowel Disease Campaign, Co-Chair
1980-present, Crohn's and Colitis Foundation of America
- 2012-present, Principal Investigator, ProKiids
- 2011-present, Oversight Committee, Pediatric Risk Stratification Group
- 2010-present, Principal Investigator, Pediatric Risk Stratification Group
- 2005-present, Quality Improvement/Adverse Event Tracking Focus Group
Editorial and Academic Positions
Editorial positions
2006-present, Gastroenterology and Hepatology, editorial advisory board
2003-present, Clinical Gastroenterology and Hepatology, reviewer
2001-present, emedicine: PEDIATRICS, Medical Textbook for Health Professionals and Consumers, medical editor
1996-present, Journal of Pediatric Gastroenterology and Nutrition, reviewer
Academic and Institutional Committees
2015-present, Pediatric Advisory Board, AbbVie
2014-present, Pediatric Advisory Board, Vedolizumab
2012-present, Resident Search Committee, Children's Hospital of Philadelphia
Research Interests
Pediatric inflammatory bowel disease
Education & training
Undergraduate Degree
BS - State University at Albany, Albany, NY
Medical Degree
MD - SUNY Health Science Center at Brooklyn, College of Medicine, Brooklyn, NY
Residency
Pediatrics - Children's Hospital of Philadelphia, Philadelphia, PA
Fellowship
Pediatric Gastroenterology and Nutrition (clinical and research fellowships) - Children's Hospital of Philadelphia
Publications
Publications
These publications were selected out of 355 peer-reviewed publications.
2023
Marcovitch L, Focht G, Carmon N, Tersigni C, Ledder O, Lev-Tzion R, Church PC, Hyams JS, Baldassano RN, Bousvaros A, Mack DR, Hussey S, Otley A, Croft NM, Kappelman MD, Griffiths AM, Turner D: Development and Validation of the TUMMY-UC: A Patient-Reported Outcome for Pediatric Ulcerative Colitis. Gastroenterology. Gastroenterology 2023 April 2023.
Focht G, Kuint RC, Greer MC, Pratt LT, Castro DA, Church PC, Navas-López VM, Baldassano RN, Mortensen JH, Rieder F, Yerushalmi B, Ilivitzki A, Konen O, Griffiths AM, Turner D: Prospective Validation of the Lémann Index in Children: A Report From the Multicentre Image Kids Study. J Crohns Colitis. 2023 June 2023.
Zhou Y, Shi J, Stein R, Liu X, Baldassano RN, Forrest CB, Chen Y, Huang J: Missing data matter: an empirical evaluation of the impacts of missing EHR data in comparative effectiveness research. . J Am Med Inform Assoc June 2023.
Harris RA, Bush AH, Eagar TN, Qian J, Greenwood MP, Opekun AR, Baldassano R, Guthery SL, Noe JD, Otley A, Rosh JR, Kugathasan S, Kellermayer R: Exome Sequencing Implicates DGKZ, ESRRA, and GXYLT1 for Modulating Granuloma Formation in Crohn's Disease. J Pediatr Gastroenterol Nutr. 2023 EBUB AHEAD OF PRINT 2023.
2022
344. Lichtenstein GR, Shahabi A, Seabury SA, Lakdawalla DN, Espinosa OD, Green S, Brauer M, Baldassano RN. : Increased Lifetime Risk of Intestinal Complications and Extraintestinal Manifestations in Crohn's Disease and Ulcerative Colitis. Gastroenterol Hepatol (N Y) 18(1): 32-43, Jan 2022.
Hyams JS, Brimacombe M, Haberman Y, Walters T, Gibson G, Mo A, Mack D, Griffiths A, Boyle B, LeLeiko N, Markowitz J, Rosh J, Patel A, Shah S, Baldassano R, Pfefferkorn M, Sauer C, Dailey J, Venkateswaran S, Kugathasan S, Denson LA.: Clinical and Host Biological Factors Predict Colectomy Risk in Children Newly Diagnosed With Ulcerative Colitis. Inflamm Bowel Dis. 28(2): 151-160, Feb 2022 Notes: Epub ahead of print.
Chen A, Stein R, Baldassano RN, Huang J.: Learning Longitudinal Patterns and Subtypes of Pediatric Crohn Disease Treated with Infliximab via Trajectory Cluster Analysis. J Pediatr Gastroenterol Nutr. 74(3): 383-388, March 2022 Notes: doi: 10.1097/MPG.0000000000003370. Epub ahead of print Dec 2021.
Clarkston K, Karns R, Jegga AG, Sharma M, Fox S, Ojo BA, Minar P, Walters TD, Griffiths AM, Mack DR, Boyle B, LeLeiko NS, Markowitz J, Rosh JR, Patel AS, Shah S, Baldassano RN, Pfefferkorn M, Sauer C, Kugathasan S, Haberman Y, Hyams JS, Denson LA, Rosen MJ: Targeted Assessment of Mucosal Immune Gene Expression Predicts Clinical Outcomes in Children with Ulcerative Colitis. J Crohns Colitis 75, Jun 2022 Notes: doi: 10.1093/ecco-jcc/jjac075. Epub ahead of print.
Clarkston K, Karns R, Jegga AG, Sharma M, Fox S, Ojo BA, Minar P, Walters TD, Griffiths AM, Mack DR, Boyle B, LeLeiko NS, Markowitz J, Rosh JR, Patel AS, Shah S, Baldassano RN, Pfefferkorn M, Sauer C, Kugathasan S, Haberman Y, Hyams JS, Denson LA, Rosen MJ: Targeted Assessment of Mucosal Immune Gene Expression Predicts Clinical Outcomes in Children with Ulcerative Colitis. J Crohns Colitis jjac075, Jun 2022 Notes: doi: 10.1093/ecco-jcc/jjac075. Epub ahead of print.
Breton J, Tanes C, Tu V, Albenberg L, Rowley S, Devas N, Hwang R, Kachelries K, Wu GD, Baldassano RN, Bittinger K, Mattei P.: A Microbial Signature for Pediatric Perianal Crohn's Disease. J Crohns Colitis 32, August 2022 Notes: doi: 10.1093/ecco-jcc/jjac032.
Turpin W, Dong M, Sasson G, Raygoza Garay JA, Espin-Garcia O, Lee SH, Neustaeter A, Smith MI, Leibovitzh H, Guttman DS, Goethel A, Griffiths AM, Huynh HQ, Dieleman LA, Panaccione R, Steinhart AH, Silverberg MS, Aumais G, Jacobson K, Mack D, Murthy SK, Marshall JK, Bernstein CN, Abreu MT, Moayyedi P, Paterson AD; Crohn's and Colitis Canada (CCC) Genetic, Environmental, Microbial (GEM) Project Research Consortium, Xu W, Croitoru K. : Mediterranean-Like Dietary Pattern Associations With Gut Microbiome Composition and Subclinical Gastrointestinal Inflammation. Gastroenterology August 2022 Notes: 2022 Aug 30;16(8):1281-1292. doi: 10.1093/ecco-jcc/jjac032. PMID: 35211723.
Smith AB, Jenior ML, Keenan O, Hart JL, Specker J, Abbas A, Rangel PC, Di C, Green J, Bustin KA, Gaddy JA, Nicholson MR, Laut C, Kelly BJ, Matthews ML, Evans DR, Van Tyne D, Furth EE, Papin JA, Bushman FD, Erlichman J, Baldassano RN, Silverman MA, Dunny GM, Prentice BM, Skaar EP, Zackular JP. : Enterococci enhance Clostridioides difficile pathogenesis. Nature. 2022 Nov 16. doi: 10.1038/s41586-022-05438-x. Epub ahead of print. PMID: 36385534. November 2022.
2021
335. Moore H, Wechsler J, Frost C, Whiteside E, Baldassano R, Markowitz J, Muir AB. : Comorbid Diagnosis of Eosinophilic Esophagitis and Inflammatory Bowel Disease in the Pediatric Population J Pediatr Gastroenterol Nutr. 72(3): 393-403, March 2021 Notes: doi:10.1097/MPG.0000000000003002.
Somineni HK, Nagpal S, Venkateswaran S, Cutler DJ, Okou DT, Haritunians T, Simpson CL, Begum F, Datta LW, Quiros AJ, Seminerio J, Mengesha E, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Iskandar H, Dryden GW, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kuemmerle JF, Lazarev M, Li E, Mannon P, Moulton DE, Newberry RD, Patel AS, Pekow J, Saeed SA, Valentine JF, Wang MH, McCauley JL, Abreu MT, Jester T, Molle-Rios Z, Palle S, Scherl EJ, Kwon J, Rioux JD, Duerr RH, Silverberg MS, Zwick ME, Stevens C, Daly MJ, Cho JH, Gibson G, McGovern DPB, Brant SR, Kugathasan S: Whole-genome sequencing of African Americans implicates differential genetic architecture in inflammatory bowel disease. Am J Hum Genet March 2021 Notes: Epub Feb 2021. doi:10.1016/j.ajhg.2021.02.001.
Weiss SL, Bittinger K, Lee JJ, Friedman ES, Mattei LM, Graham K, Zhang D, Bush J, Balamuth F, McGowan FX Jr, Bushman FD, Baldassano RN, Wu GD, Wallace DC, Collman RG.: Decreased Intestinal Microbiome Diversity in Pediatric Sepsis: A Conceptual Framework for Intestinal Dysbiosis to Influence Immunometabolic Function. Crit Care Explor. Mar 2021 Notes: doi:10.1097/CCE.0000000000000360.
Mitchel EB, Rosenbaum S, Gaeta C, Huang J, Raffini LJ, Baldassano RN, Denburg MR, Albenberg L.: Venous Thromboembolism in Pediatric Inflammatory Bowel Disease: A Case-Control Study. J Pediatr Gastroenterol Nutr. 72(5): 742-747, May 2021 Notes: Epubdoi:10.1097/MPG.0000000000003078.
Berry ASF, Pierdon MK, Misic AM, Sullivan MC, O'Brien K, Chen Y, Murray SJ, Ramharack LA, Baldassano RN, Parsons TD, Beiting DP.: Remodeling of the maternal gut microbiome during pregnancy is shaped by parity. Microbiome 9(1): 146, June 2021 Notes: doi: 10.1186/s40168-021-01089-8.
Moore H, Dubes L, Fusillo S, Baldassano R, Stein R: Tofacitinib Therapy in Children and Young Adults with Pediatric-Onset Medically-Refractory Inflammatory Bowel Disease. J Pediatr Gastroenterol Nutr. 73(3): e57-e62, June 2021 Notes: doi: 10.1097/MPG.0000000000003190.
Marcovitch L, Focht G, Horesh A, Shosberger A, Hyams J, Bousvaros A, Hale AE, Baldassano R, Otley A, Mack DR, Kappelman MD, Griffiths AM, Turner D.: Agreement on Symptoms Between Children With Ulcerative Colitis and Their Caregivers: Towards Developing the TUMMY-UC. J Pediatr Gastroenterol Nutr. 73(2): e35-e38, August 2021 Notes: doi: 10.1097/MPG.0000000000003120.
Mo A, Nagpal S, Gettler K, Haritunians T, Giri M, Haberman Y, Karns R, Prince J, Arafat D, Hsu NY, Chuang LS, Argmann C, Kasarskis A, Suarez-Farinas M, Gotman N, Mengesha E, Venkateswaran S, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, LeLeiko NS, Heyman MB, Griffiths AM, Patel AS, Noe JD, Davis Thomas S, Aronow BJ, Walters TD, McGovern DPB, Hyams JS, Kugathasan S, Cho JH, Denson LA, Gibson G.: Stratification of risk of progression to colectomy in ulcerative colitis via measured and predicted gene expression. Am J Hum Genet. 108(9): 1765-1779, September 2021 Notes: doi: 10.1016/j.ajhg.2021.07.013. Epub 2021 Aug 26.
Ta AD, Ollberding NJ, Karns R, Haberman Y, Alazraki AL, Hercules D, Baldassano R, Markowitz J, Heyman MB, Kim S, Kirschner B, Shapiro JM, Noe J, Oliva-Hemker M, Otley A, Pfefferkorn M, Kellermayer R, Snapper S, Rabizadeh S, Xavier R, Dubinsky M, Hyams J, Kugathasan S, Jegga AG, Dillman JR, Denson LA.: Association of Baseline Luminal Narrowing With Ileal Microbial Shifts and Gene Expression Programs and Subsequent Transmural Healing in Pediatric Crohn Disease. Inflamm Bowel Dis. 27(11): 1707-1718, Oct 2021 Notes: doi: 10.1093/ibd/izaa339.
2020
Haberman Yael, Karns Rebekah, Dexheimer Phillip J, Schirmer Melanie, Somekh Judith, Jurickova Ingrid, Braun Tzipi, Novak Elizabeth, Bauman Laura, Collins Margaret H, Mo Angela, Rosen Michael J, Bonkowski Erin, Gotman Nathan, Marquis Alison, Nistel Mason, Rufo Paul A, Baker Susan S, Sauer Cary G, Markowitz James, Pfefferkorn Marian D, Rosh Joel R, Boyle Brendan M, Mack David R, Baldassano Robert N, Shah Sapana, Leleiko Neal S, Heyman Melvin B, Grifiths Anne M, Patel Ashish S, Noe Joshua D, Aronow Bruce J, Kugathasan Subra, Walters Thomas D, Gibson Greg, Thomas Sonia Davis, Mollen Kevin, Shen-Orr Shai, Huttenhower Curtis, Xavier Ramnik J, Hyams Jeffrey S, Denson Lee A: Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nature communications 10(1): 38, Jan 2020.
Turner Dan, Griffiths Anne M, Wilson David, Mould Diane R, Baldassano Robert N, Russell Richard K, Dubinsky Marla, Heyman Melvin B, de Ridder Lissy, Hyams Jeffrey, Martin de Carpi Javier, Conklin Laurie, Faubion William A, Koletzko Sibylle, Bousvaros Athos, Ruemmele Frank M: Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary. Gut Jan 2020 Notes: [epub 2019 Apr 12]
Lichtenstein Gary R, Shahabi Ahva, Seabury Seth A, Lakdawalla Darius N, Espinosa Oliver Díaz, Green Sarah, Brauer Michelle, Baldassano Robert N: Lifetime Economic Burden of Crohn's Disease and Ulcerative Colitis by Age at Diagnosis. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 18(4): 889-897.e10, Apr 2020.
Liang G, Zhao C, Zhang H, Mattei L, Sherrill-Mix S, Bittinger K, Kessler LR, Wu GD, Baldassano RN, DeRusso P, Ford E, Elovitz MA, Kelly MS, Patel MZ, Mazhani T, Gerber JS, Kelly A, Zemel BS, Bushman FD.: The Stepwise Assembly of the Neonatal Virome Is Modulated by Breastfeeding. Nature Page: 470-474, May 2020 Notes: Epub 2020 Apr 15.
Moore Hillary, Dolce Pasquale, Devas Nina, Baldassano Robert, Martinelli Massimo: Post-induction infliximab trough levels and disease activity in the clinical evolution of pediatric ulcerative colitis. United European gastroenterology journal Page: 2050640620912877, May 2020 Notes: [Epub 2020 Mar 12]
Berry ASF, Johnson K, Martins R, Sullivan MC, Farias Amorim C, Putre A, Scott A, Wang S, Lindsay B, Baldassano RN, Nolan TJ, Beiting DP. : Natural Infection with Giardia Is Associated with Altered Community Structure of the Human and Canine Gut Microbiome. mSphere 5(4), Aug 2020.
Breton J, Kastl A, Conrad MA, Baldassano RN: Positioning Biologic Therapies in the Management of Pediatric Inflammatory Bowel Disease. Gastroenterol Hepatol 16(8): 400-414, August 2020.
Haberman Y, Minar P, Karns R, Dexheimer PJ, Ghandikota S, Tegge S, Shapiro D, Shuler B, Venkateswaran S, Braun T, Ta A, Walters TD, Baldassano RN, Noe JD, Rosh J, Markowitz J, Dotson JL, Mack DR, Kellermayer R, Griffiths AM, Heyman MB, Baker SS, Moulton D, Patel AS, Gulati AS, Steiner SJ, LeLeiko N, Otley A, Oliva-Hemker M, Ziring D, Gokhale R, Kim S, Guthery SL, Cohen SA, Snapper S, Aronow BJ, Stephens M, Gibson G, Dillman JR, Dubinsky M, Hyams JS, Kugathasan S, Jegga AG, Denson LA.: Mucosal Inflammatory and Wound Healing Gene Programs Reveal Targets for Stricturing Behavior in Pediatric Crohn's Disease. J Crohns Colitis Aug 2020 Notes: Epub ahead of print.
Bushman FD, Conrad M, Ren Y, Zhao C, Gu C, Petucci C, Kim MS, Abbas A, Downes KJ, Devas N, Mattei LM, Breton J, Kelsen J, Marakos S, Galgano A, Kachelries K, Erlichman J, Hart JL, Moraskie M, Kim D, Zhang H, Hofstaedter CE, Wu GD, Lewis JD, Zackular JP, Li H, Bittinger K, Baldassano R. : Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease. Cell Host Microbe 28(3): 422-433, Sep 2020.
Mack DR, Saul B, Boyle B, Griffiths A, Sauer C, Markowitz J, LeLeiko N, Keljo D, Rosh JR, Baker SS, Steiner S, Heyman MB, Patel AS, Baldassano R, Noe J, Rufo P, Kugathasan S, Walters T, Marquis A, Thomas SM, Denson L, Hyams J; PROTECT STUDY GROUP.: Analysis of Using the Total White Blood Cell Count to Define Severe New Onset Ulcerative Colitis in Children. Journal of pediatric gastroenterology and nutrition. Sep 2020.
Turpin W, Bedrani L, Espin-Garcia O, Xu W, Silverberg MS, Smith MI, Garay JAR, Lee SH, Guttman DS, Griffiths A, Moayyedi P, Panaccione R, Huynh H, Steinhart HA, Aumais G, Dieleman LA, Turner D, Paterson AD, Croitoru K.: Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn's disease subjects. BMC Med Genet. 21(1): 204, October 2020.
Liang G, Conrad MA, Kelsen JR, Kessler LR, Breton J, Albenberg LG, Marakos S, Galgano A, Devas N, Erlichman J, Zhang H, Mattei L, Bittinger K, Baldassano RN, Bushman FD.: The dynamics of the stool virome in very early onset inflammatory bowel disease. J Crohns Colitis November 2020 Notes: Online ahead of print May 2020.
Gu CH, Zhao C, Hofstaedter C, Tebas P, Glaser L, Baldassano R, Bittinger K, Mattei LM, Bushman FD.: Investigating hospital Mycobacterium chelonae infection using whole genome sequencing and hybrid assembly. PLoS One. 15(11), 2020 Notes: eCollection 2020.
Turpin W, Lee SH, Raygoza Garay JA, Madsen KL, Meddings JB, Bedrani L, Power N, Espin-Garcia O, Xu W, Smith MI, Griffiths AM, Moayyedi P, Turner D, Seidman EG, Steinhart HA, Marshall JK, Jacobson K, Mack D, Huynh H, Bernstein CN, Paterson AD; Crohn's and Colitis Canada Genetic Environmental Microbial Project Research Consortium; CCC GEM Project recruitment site directors include Maria Abreu, Croitoru K: Increased Intestinal Permeability Is Associated With Later Development of Crohn's Disease. Gastroenterology 5085(20), December 2020 Notes: Online ahead of print Aug 2020.
2019
Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Alexander Valencia D, Dodd A, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery SL, Dubinsky MC, Leleiko NS, Otley AR, Xavier RJ, Stevens C, Daly MJ, Zwick ME, Kugathsan S. Genetic and transcriptomic variation linked to neutrophil granulocyte-macrophage colony-stimulating factor signaling in pediatric Crohn’s disease. Inflamm Bowel Dis, Feb 21, 2019. Epub Aug 13, 2018. doi: 10.1093/ibd/izy265. PMID: 30124884.
Haberman Y, Schirmer M, Dexheimer PJ, Karns R, Braun T, Kim MO, Walters TD, Baldassano RN, Noe JD, Rosh J, Markowitz J, Crandall WV, Mack DR, Griffiths AM, Heyman MB, Baker SS, Kellermayer R, Moulton D, Patel AS, Gulati AS, Steiner SJ, LeLeiko N, Otley A, Oliva-Hemker M, Ziring D, Kirschner BS, Keljo DJ, Guthery SL, Cohen SA, Snapper S, Evans J, Dubinsky M, Aronow B, Hyams JS, Kugathasan S, Huttenhower C, Xavier RJ, Denson LA. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn disease patients despite already established dysbiosis. Mucosal Immunol, Mar 12, 2019. Epub Dec 12, 2018. doi: 10.1038/s41385-018-0114-4. PMID: 30542108.
Haberman Y, Karns R, Dexheimer PJ, Schirmer M, Somekh J, Jurickova I, Braun T, Novak E, Bauman L, Collins MH, Mo A, Rosen MJ, Bonkowski E, Gotman N, Marquis A, Nistel M, Rufo PA, Baker SS, Sauer CG, Markowitz J, Pfefferkorn MD, Rosh JR, Boyle BM, Mack DR, Baldassano RN, Shah S, Leleiko NS, Heyman MB, Grifiths AM, Patel AS, Noe JD, Aronow BJ, Kugathasan S, Walters TD, Gibson G, Thomas SD, Mollen K, Shen-Orr S, Huttenhower C, Xavier RJ, Hyams JS, Denson LA. Ulcerative colitis mucosal transcriptomes reveal mitochondriopathy and personalized mechanisms underlying disease severity and treatment response. Nat Commun, 10(1):38, Jan 3, 2019. doi: 10.1038/s41467-018-07841-3. PMID: 30604764; PMCID: PMC6318335.
Shaw KA, Cutler DJ, Okou D, Dodd A, Aronow BJ, Haberman Y, Stevens C, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery S, Dubinsky MC, Shapiro JM, Otley AR, Daly M, Denson LA, Kugathasan S, Zwick ME. Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. Genes Immun. Feb 20, 2019. Epub 2018 Mar 28. doi: 10.1038/s41435-018-0015-2. PMID: 29593342; PMCID: PMC6162182.
Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Valencia CA, Dodd A, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery SL, Dubinsky MC, Leleiko NS, Otley AR, Xavier RJ, Stevens C, Daly MJ, Zwick ME, Kugathasan S. Genetic and Transcriptomic Variation Linked to Neutrophil Granulocyte-Macrophage Colony-Stimulating Factor Signaling in Pediatric Crohn's Disease. Inflamm Bowel Dis. Feb 21, 2019. doi: 10.1093/ibd/izy265. PMID: 30124884; PMCID: PMC6391846.
Haberman Y, Schirmer M, Dexheimer PJ, Karns R, Braun T, Kim MO, Walters TD, Baldassano RN, Noe JD, Rosh J, Markowitz J, Crandall WV, Mack DR, Griffiths AM, Heyman MB, Baker SS, Kellermayer R, Moulton D, Patel AS, Gulati AS, Steiner SJ, LeLeiko N, Otley A, Oliva-Hemker M, Ziring D, Kirschner BS, Keljo DJ, Guthery SL, Cohen SA, Snapper S, Evans J, Dubinsky M, Aronow B, Hyams JS, Kugathasan S, Huttenhower C, Xavier RJ, Denson LA. Age-of-diagnosis dependent ileal immune intensification and reduced alpha-defensin in older versus younger pediatric Crohn Disease patients despite already established dysbiosis. Mucosal Immunol. Mar 12, 2019. Epub 2018 Dec 12. doi: 10.1038/s41385-018-0114-4. PMID: 30542108; PMCID: PMC6375755.
Zhou L, Chu C, Teng F, Bessman NJ, Goc J, Santosa EK, Putzel GG, Kabata H, Kelsen JR, Baldassano RN, Shah MA, Sockolow RE, Vivier E, Eberl G, Smith KA, Sonnenberg GF. Innate lymphoid cells support regulatory T cells in the intestine through interleukin-2. Nature. Apr 3, 2019. Epub 2019 Apr 3. doi: 10.1038/s41586-019-1082-x. PMID: 30944470.
Hyams JS, Davis Thomas S, Gotman N, Haberman Y, Karns R, Schirmer M, Mo A, Mack DR, Boyle B, Griffiths AM, LeLeiko NS, Sauer CG, Keljo DJ, Markowitz J, Baker SS, Rosh J, Baldassano RN, Patel A, Pfefferkorn M, Otley A, Heyman M, Noe J, Oliva-Hemker M, Rufo PA, Strople J, Ziring D, Guthery SL, Sudel B, Benkov K, Wali P, Moulton D, Evans J, Kappelman MD, Marquis MA, Sylvester FA, Collins MH, Venkateswaran S, Dubinsky M, Tangpricha V, Spada KL, Saul B, Wang J, Serrano J, Hommel K, Marigorta UM, Gibson G, Xavier RJ, Kugathasan S, Walters T, Denson LA. Clinical and biological predictors of response to standardised paediatric colitis therapy (PROTECT): a multicentre inception cohort study. Lancet. Apr 27, 2019. Epub Mar 29, 2019.doi: 10.1016/S0140-6736(18)32592-3. PMID: 30935734.
Wu J, Lubman DM, Kugathasan S, Denson LA, Hyams JS, Dubinsky MC, Griffiths AM, Baldassano RN, Noe JD, Rabizadeh S, Gulati AS, Rosh JR, Crandall WV, Higgins PDR, Stidham RW. Serum Protein Biomarkers of Fibrosis Aid in Risk Stratification of Future Structuring Complications in Pediatric Crohn's Disease. Am J Gastroenterol. May 11, 2019. doi: 10.14309/ajg.00000000000002 37. PMID: 31058681.
Tokarz R, Hyams JS, Mack DR, Boyle B, Griffiths AM, LeLeiko NS, Sauer CG, Shah S, Markowitz J, Baker SS, Rosh J, Baldassano RN, Kugathasan S, Walters T, Tagliafierro T, Sameroff S, Lee B, Che X, Oleynik A, Denson LA, Lipkin WI. Characterization of Stool Virome in Children Newly Diagnosed With Moderate to Severe Ulcerative Colitis. Inflamm Bowel Dis. May 21, 2019. doi: 10.1093/ibd/izz099. [Epub ahead of print] PMID: 31112614.
Somineni HK, Venkateswaran S, Kilaru V, Marigorta UM, Mo A, Okou DT, Kellermayer R, Mondal K, Cobb D, Walters TD, Griffiths A, Noe JD, Crandall WV, Rosh JR, Mack DR, Heyman MB, Baker SS, Stephens MC, Baldassano RN, Markowitz JF, Dubinsky MC, Cho J, Hyams JS, Denson LA, Gibson G, Cutler DJ, Conneely KN, Smith AK, Kugathasan S. Blood-derived DNA methylation signatures of Crohn's Disease and severity of intestinal inflammation. Gasteroenterol, Jun 2019. Epub Feb 16, 2019. doi: 10.1053/j.gastro.2019.01.270. PMID: 30779925.
Krishnakumar C, Ballengee CR, Liu C, Kim MO, Baker SS, Baldassano RN, Cohen SA, Crandall WV, Denson LA, Dubinsky MC, Evans J, Gokhale R, Griffiths A, Guthery SL, Oliva-Hemker M, Heyman MB, Keljo D, Kellermayer R, Leleiko NS, Mack DR, Markowitz JF, Moulton DE, Noe JD, Otley AR, Patel AS, Pfefferkorn M, Rabizadeh S, Rosh JR, Snapper S, Walters TD, Ziring D, Mondal K, Kappelman MD, Hyams JS, Kugathasan S. Variation in care in the management of children with Crohn’s disease: Data from a multicenter inception cohort study. Inflamm Bowel Dis. Jun 18, 2019. Epub Jan 2, 2019. doi: 10.1093/ibd/izy363. PMID: 30601983.
Ballengee CR, Stidham RW, Liu C, Kim MO, Prince J, Mondal K. Baldassano RN, Dubinsky M, Markowitz J, Leleiko N, Hyams J, Denson L, Kugathasan S. Association between plasma level of collagen type III alpha 1 chain and development of strictures in pediatric patients with Crohn’s disease. Clin Gastroenterol Hepatol Aug 17, 2019. Epub Sep 10, 2018, pii: S1542-3565(18)30969-8. doi: 10/1016/j.cgh.2018.09.008. [Epub ahead of print]. PMID: 30213581.
Breton J, Kastl A, Hoffmann N, Rogers R, Grossman AB, Mamula P, Kelsen JR, Baldassano RN, Albenberg L. Efficacy of combination antibiotic therapy for refractory pediatric inflammatory bowel disease. Inflamm Bowel Dis, Aug 20, 2019. Epub doi: 10.1093/ibd/izz006. PMID: 30715364.
Turner D, Griffiths AM, Wilson D, Mould DR, Baldassano RN, Russell RK, Dubinsky M, Heyman MB, de Ridder L, Hyams J, Martin de Carpi J, Conklin L, Faubion WA, Koletzko S, Bousvaros A, Ruemmele FM. Designing clinical trials in paediatric inflammatory bowel diseases: a PIBDnet commentary. Gut 2020 Jan. Epub 2019 Apr 12. doi: 10.1136/gutjnl-2018-317987. PMID: 30979718.
2018
Atkinson MA, Leonard MB, Herskovitz R, Baldassano RN, Denburg MR. Changes in hepcidin and hemoglobin after anti-TNF-alpha therapy in children and adolescents with Crohn’s disease. J Pediatr Gastroenterol Nutr, 66(1):90-94, Jan 2018. PMID: 28604512. PMCID: 5723254 [available on 2019-01-01]..
Haberman Y, BenShoshan M, Di Segni A, Dexheimer PJ, Braun T, Weiss B, Walters TD, Baldassano RN, Noe JD, Markowitz J, Rosh J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Kellermayer R, Patel A, Otley A, Steiner SJ, Gulati AS, Guthery SL, LeLeiko N, Moulton D, Kirschner BS, Snapper S, Avivi C, Barshack I, Oliva-Hemker M, Cohen SA, Keljo DJ, Ziring D, Anikster Y, Aronow B, Hyams JS, Kugathasan S, Denson LA. Long ncRNA landscape in the ileum of treatment-naive early-onset Crohn disease. Inflamm Bowel Dis, 24(2):346-360, Jan 18, 2018. PMID: 29361088.
Sahn B, De Matos V, Stein R, Ruchelli E, Masur S, Klink AJ, Baldassano RN, Piccoli DA, Russo P, Mamula P. Histological features of ileitis differentiating pediatric Crohn disease from ulcerative colitis with backwash ileitis. Dig Liver Dis, 50(2):147-153, Feb 2018. Epub 2017 Oct 19. PMID: 290829273.
Stein RE, Plantz K, Maxwell EC, Mamula P, Baldassano RN. Intravenous iron sucrose for treatment of iron deficiency anemia in pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr, 66(2):e51-e55, Feb 2018. PMID: 28704225.
Sauer CG, Loop MS, Venkateswaran S, Tangpricha V, Ziegler TR, Dhawan A, McCall C, Bonkowski E, Mack DR, Boyle B, Griffiths AM, Leleiko NS, Keljo DJ, Markowitz J, Baker SS, Rosh J, Baldassano RN, Davis S, Patel S, Wang J, Marquis A, Spada KL, Kugathasan S, Walters T, Hyams JS, Denson LA. Free and bioavailable 25-Hydroxyvitamin D concentrations are associated with disease activity in pediatric patients with newly diagnosed treatment naïve ulcerative colitis. Inflamm Bowel Dis, 15;24(3):641-650, Feb 15, 2018. PMID: 29462384.
DeBoer MD, Lee AM, Herbert K, Long J, Thayu M, Griffin LM, Baldassano RN, Denson LA, Zemel BS, Denburg MR, Herskovitz R, Leonard MB. Increases in IGF-1 after anti-TNF-α therapy are associated with bone and muscle accrual in pediatric Crohn’s disease. J Clin Endocrinol Metab, 103(3):936-945, Mar 1, 2018. doi: 10.1210/jc.2017-01916. PMID: 29329430
Venkateswaran S, Prince J, Cutler DJ, Marigorta UM, Okou DT, Prahalad S, Mack D, Boyle B, Walters T, Griffiths A, Sauer CG, LeLeiko N, Keljo D, Markowitz J, Baker SS, Rosh J, Pfefferkorn M, Heyman MB, Patel A, Otley A, Baldassano RN, Noe J, Rufo P, Oliva-Hemker M, Davis S, Zwick ME, Gibson G, Denson LA, Hyams J, Kugathasan S. Enhanced contribution of HLA in pediatric onset ulcerative colitis. Inflamm Bowel Dis, 24(4):829-838, Mar 19, 2018. doi: 10.1093/ibd/izx084. PMID: 29562276.
Shaw KA, Cutler DJ, Okou D, Dodd A, Aronow BJ, Haberman Y, Stevens C, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery S, Dubinsky MC, Shapiro JM, Otley AR, Daly M, Denson LA, Kugathasan S, Zwick ME. Genetic variants and pathways implicated in a pediatric inflammatory bowel disease cohort. Genes Immun, Mar 28, 2018. doi: 10.1038/s41435-018-0015-2. [Epub ahead of print]. PMID: 29593342.
Lee D, Lewis JD, Shults J, Baldassano RN, Long J, Herskovitz R, Zemel B, Leonard MB. The association of diet and exercise with body composition in pediatric Crohn’s disease. Inflamm Bowel Dis, 24(6):1368-1375, May 18, 2018. doi: 10.1093/ibd/izy024. PMID: 29718224.
Spencer EA, Davis SM, Mack DR, Boyle BM, Griffiths AM, LeLeiko NS, Sauer CG, Keljo DJ, Markowitz JF, Baker SS, Rosh JR, Baldassano RN, Oliva-Hemker M, Pfefferkorn MD, Otley AR, Heyman MB, Noe JD, Patel AS, Rufo PA; PROTECT Study Group, Alison Marquis M, Walters TD, Collins MH, Kugathasan S, Denson LA, Hyams JS, Dubinsky MC. Serologic reactivity reflects clinical expression of ulcerative colitis in children. Inflamm Bowel Dis, 24(6):1335-1343, May 18, 2018. doi: 10.1093/ibd/izy009. PMID: 29718391.
Lee D, Swan CK, Suskind D, Wahbeh G, Vanamala J, Baldassano RN, Leonard MB, Lampe JW. Children with Crohn’s disease frequently consume select food additives. Dig Dis Sci, 63(10):2722-2728, Oct 2018. doi: 10.1007/s10620-018-5145-x. Epub 2018 Jun 4. PMID: 29862484.
Momozawa Y, Dmitrieva J, Théâtre E, Deffontaine V, Rahmouni S, Charloteaux B, Crins F, Docampo E, Elansary M, Gori AS, Lecut C, Mariman R, Mni M, Oury C, Altukhov I, Alexeev D, Aulchenko Y, Amininejad L, Bouma G, Hoentjen F, Löwenberg M, Oldenburg B, Pierik MJ, Vander Meulen-deJong AE, Janneke van der Woude C, Visschedijk MC; International IBD Genetics Consortium, Lathrop M, Hugot JP, Weersma R, DeVos M, Franchimont D, Vermeire S, Kubo M, Louis E, Georges M, [Baldassano RN, collaborator]. IBD risk loci are enriched in multigenic regulatory modules encompassing putative causative genes. Nat Commun, 9(1):2427, Jun 21, 2018. doi: 10.1038/s41467-018-04365-8. PMID: 29930244. PMCID: PMC6013502.
Denson LA, Jurickova I, Karns R, Shaw KA, Cutler DJ, Okou D, Dodd A, Quinn K, Mondal K, Aronow BJ, Haberman Y, Linn A, Price A, Bezold R, Lake K, Jackson K, Walters TD, Griffiths A, Baldassano RN, Noe JD, Hyams JS, Crandall WV, Kirschner BS, Heyman MB, Snapper S, Guthery SL, Dubinsky MC, Leleiko NS, Otley AR, Xavier RJ, Stevens C, Daly MJ, Zwick ME, Kugathasan S. Clinical and genomic correlates of neutrophil reactive oxygen species production in pediatric patients with Crohn’s disease. Gastroenterology, 154(8):2097-2110, Jun 2018. doi: 10.1053/j.gastro.2018.02.016. Epub 2018 Feb 15. PMID: 29454792.
Church PC, Kuint RC, Ledder O, Navas-López VM, Sladek M, Brückner A, Baldassano RN, Weiss B, Yerushalmi B, Saeed SA, Hyams J, Otley A, Griffiths AM, Turner D, Greer MC; ImageKids Study group. Magnetic resonance enterography cannot replace upper endoscopy in pediatric Crohn’s disease: An ImageKids sub-study. J Pediatr Gastroenterol Nutr, 67(1):53-58, Jul 2018. PMID: 29287012.
Kelly D, Kotliar M, Woo V, Jagannathan S, Whitt J, Moncivaiz J, Aronow BJ, Dubinsky MC, Hyams JS, Markowitz JF, Baldassano RN, Stephens MC, Walters TD, Kugathasan S, Haberman Y, Sundaram N, Rosen MJ, Helmrath M, Karns R, Barski A, Denson LA, Alenghat T. Microbiota-sensitive epigenetic signature predicts inflammation in Crohn’s disease. JCI Insight, 3(18), Sept 20, 2018. pii: 122104. doi: 10.1172/jci.insight.122104. PMID: PMC6237229
Schirmer M, Denson L, Vlamakis H, Franzosa EA, Thomas S, Gotman NM, Rufo P, Baker SS, Sauer C, Markowitz J, Pfefferkorn M, Oliva-Hemker M, Rosh J, Otley A, Boyle B, Mack D, Baldassano RN, Keljo D, LeLeiko N, Heyman M, Griffiths A, Patel AS, Noe J, Kugathasan S, Walters T, Huttenhower C, Hyams J, Xavier RJ. Compositional and temporal changes in the gut microbiome of pediatric ulcerative colitis patients are linked to disease course. Cell Host Microbe, 24(4):600-610.e4, Oct 10, 2018. doi: 10.1016/j.chom.2018.09/009. PMID: 30308161.
Lindoso L, Mondal K, Venkateswaran S, Somineni HK, Ballengee C, Walters TD, Griffiths A, Noe JD, Crandall W, Snapper S, Rabizadeh S, Rosh JR, LeLeiko N, Guthery S, Mack D, Kellermayer R, Gulati AS, Pfefferkorn MD, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley A, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Stephens MC, Baldassano RN, Dubinsky MC, Markowitz J, Denson LA, Hyams J, Kugathasan S, Ananthakrishnan AN. The effect of early-life environmental exposures on disease phenotype and clinical course of Crohn’s disease in children. Am J Gastroenterol, Oct 11, 2018. Epub Sept 28, 2018. doi: 10.1038/s41395-018-0239-9. PMID: 30267029.
2017
Brant SR, Okou DT, Simpson CL, Cutler DJ, Haritunians T, Bradfield JP, Chopra P, Prince J, Begum F, Kumar A, Huang C, Venkateswaran S, Datta LW, Wei Z, Thomas K, Herrinton LJ, Klaproth JA, Quiros AJ, Seminerio J, Liu Z, Alexander JS, Baldassano RN, Dudley-Brown S, Cross RK, Dassopoulos T, Denson LA, Dhere TA, Dryden GW, Hanson JS, Hou JK, Hussain SZ, Hyams JS, Isaacs KL, Kader H, Kappelman MD, Katz J, Kellermayer R, Kirschner BS, Kuemmerle JF, Kwon JH, Lazarev M, Li E, Mack D, Mannon P, Moulton DE, Newberry RD, Osuntokun BO, Patel AS, Saeed SA, Targan SR, Valentine JF, Wang MH, Zonca M, Rioux JD, Duerr RH, Silverberg MS, Cho JH, Hakonarson H, Zwick ME, McGovern DP, Kugathasan S. Genome-wide association study identifies African-specific susceptibility loci in African Americans with inflammatory bowel disease. Gastroenterology, 152(1):206-217,Jan 2017. e2. doi: 10.1053/j.gastro.2016.09/032. PMID: 27693347.
Kugathasan S, Denson L, Walters T, Kim MO, Marigorta U, Schirmer M, Mondal K, Liu C, Stephens M, Baldassano RN, Markowitz J, Xavier R, Aronow B, Gibson G, Hyams J, Dubinsky M, RISK Stratification Study Pediatric. O-002 Predicting a complicated course for children newly diagnosed with Crohn’s disease: A multicenter inception cohort study. Inflamm Bowel Dis, 23 Suppl 1:S1, Feb 2017. Doi: 10.1097/01. MIB.0000512512.2322.2f.
Haberman Y, Ben-Shoshan M, Di-Segni A, Dexheimer P, Klein T, Weiss B, Walters T, Baldassano RN, Noe J, Markowitz J, Heyman M, Rosh J, Griffiths A, Crandall W, Aronow B, Anikster Y, Hyams J, Kugathasan S, Denson L. O-009 Long ncRNA landscape in the ileum of treatment naïve early onset Crohn disease. Inflamm Bowel Dis, 23: Suppl 1:S3-S4, Feb 2017. doi: 10.1097/01. MIB.0000512519.99457.e4.
Hyams JS, Dubinsky MC, Baldassano RN, Colletti RB, Cucchiara S, Escher J, Faubion W, Fell J, Gold BD, Griffiths A, Koletzko S, Kugathasan S, Markowitz J, Ruemmele FM, Veereman G, Winter H, Masel N, Shin CR, Tang KL, Thayu M. Infliximab is not associated with increased risk of malignancy or hemophagocytic lymphohistiocytosis in pediatric patients with inflammatory bowel disease. Gastroenterology,152:1901-1914, Feb 10, 2017. PMID: 28193515.
Kugathasan S, Denson LA, Walters TD, Kim MO, Marigorta UM, Schirmer M, Mondal K, Liu C, Griffiths A, Noe JD, Crandall WV, Snapper S, Rabizadeh S, Rosh JR, Shapiro JM, Guthery S, Mack DR, Kellermayer R, Kappelman MD, Steiner S, Moulton DE, Keljo D, Cohen S, Oliva-Hemker M, Heyman MB, Otley AR, Baker SS, Evans JS, Kirschner BS, Patel AS, Ziring D, Trapnell BC, Sylvester FA, Stephens MC, Baldassano RN, Markowitz JF, Cho J, Xavier RJ, Huttenhower C, Aronow BJ, Gibson G, Hyams JS, Dubinsky MC. Prediction of complicated disease course for children newly diagnosed with Crohn’s disease: a multicenter inception cohort study. Lancet, 29;389(10080):1710-1718, Apr 29, 2017. Epub 2017 March 2. PMID: 28259484.
Rosen MJ, Karns R, Vallance JE, Bezold R, Waddell A, Collins MH, Haberman Y, Minar P, Baldassano RN, Hyams JS, Baker SS, Kellermayer R. Noe JD, Griffiths AM, Rosh JR, Crandall WV, Heyman MB, Mack DR, Kappelman MD, Markowitz J, Moulton DE, Lelikeo NS. Walters TD, Kugathasan S, Wilson KT, Hogan SP, Denson LA. Mucosal expression of Type 2 and Type 17 immune response genes distinguishes ulcerative colitis from colon-only Crohn’s disease in treatment-naïve pediatric patients. Gastroenterology, 152(6): 1345-1357, May 2017. Epub 2017 Jan 26. PMID: 28132889.
Kim D, Hofstaedter CE, Zhao C, Mattei L, Tanes C, Clarke E, Lauder A, Sherrill-Mix S, Chehoud C, Kelsen J, Conrad M, Collman RG, Baldassano RN, Bushman FD, Bittinger K. Optimizing methods and dodging pitfalls in microbiome research. Microbiome, 5(1):52, May 5, 2017. PMID: 28476139.
Walters TD, Faubion WA, Griffiths AM, Baldassano RN, Escher J, Ruemmele FM, Hyams JS, Lazar A, Eichner S, Huang B, Li Y, Thakkar RB. Growth improvement with adalimumab treatment in children with moderately to severely active Crohn’s disease. Inflamm Bowel Dis, 23(6):967-975, Jun 2017. PMID: 28301428.
Kelsen JR, Baldassano RN. The role of monogenic disease in children with every early onset inflammatory bowel disease. Curr Opin Pediatr, 29(5):566-571, Jul 11, 2017. PMID: 28700415. PMCID: PMC5642912.
Maxwell EC, Dawany N, Baldassano RN, Mamula P, Mattei P, Albenberg L, Kelsen JR. Diverting ileostomy for the treatment of severe, refractory, pediatric inflammatory bowel disease. J Pediatr Gastroenterol Nutr, 65(3):299-305, Sept 2017. PMID: 28045769.
Keunstner JT, Naser S, Chamberlin W, Borody T, Graham DY, McNees A, Hermon-Taylor J, Hermon-Taylor A, Dow CT, Thayer W, Biesecker J, Collins MT, Sechi LA, Singh SV, Zhang P, Shafran I, Weg S, Telega G, Rothstein R, Oken H, Schimpff S, Bach H, Bull T, Grant I, Ellingson J, Dahmen H, Lipton J, Gupta S, Chaubey K, Singh M, Agarwal P, Kumar A, Misri J, Sohal J, Dhama K, Hemati Z, Davis W, Hier M, Aitken J, Pierce E, Parrish N, Goldberg N, Kali M, Bendre S, Agrawal G, Baldassano RN, Linn P, Sweeney RW, Fecteau M, Hofstaedter C, Potula R, Timofeeva O, Geier S, John K, Zyanni N, Malaty HM, Kahlenborn C, Kravitz A, Bulfon A, Daskalopoulos G, Mitchell H, Neilan B, Timms V, Cossu D, Mameli G, Angermeier P, Jelic T, Goethe R, Juste RA, Kuenstner L. The Consensus from the Mycobacterium avium ssp. paratuberculosis (MAP) Conference 2017. Front Public Health, 5:208, Sept 27, 2017. PMID: 29021977.
Marigorta UM, Denson LA, Hyams JS, Mondal K, Prince J, Walters TD, Griffiths A, Noe JD, Crandall WV, Rosh JR, Mack DR, Kellermayer R, Heyman MB, Baker SS, Stephens MC, Baldassano RN, Markowitz JF, Kim MO, Dubinsky MC, Cho J, Aronow BJ, Kugathasan S, Gibson G. Transcriptional risk scores link GWAS to eQTLs and predict complications in Crohn’s disease. Nat Genet, 49(10):1517-1521, Oct 2017. doi: 10.1038/ng.3936. Epub 2017 Aug 14. PMID: 28805827.
Boyle B, Collins MH, Wang Z, Mack D, Griffiths A, Sauer C, Markowitz J, LeLeiko N, Keljo D, Rosh J, Baker SS, Pfefferkorn M, Heyman M, Patel A, Baldassano RN, Noe J, Rufo P, Kugathasan S, Walters T, Denson L, Hyams J; PROTECT Study Group. Histologic correlates of clinical and endoscopic severity in children newly diagnosed with ulcerative colitis. Am J Surg Pathol, 41(11):1491-1498, Nov 2017. PMID: 28863076. PMCID: PMC5636675.
Ni J, Shen TD, Chen EZ, Bittinger K, Bailey A, Roggiani M, Sirota-Madi A, Friedman ES, Chau L, Lin A, Nissim I, Scott J, Lauder A, Hoffmann C, Rivas G, Albenberg L, Baldassano RN, Braun J, Xavier RJ, Clish CB, Yudkoff M, Li H, Goulian M, Bushman FD, Lewis JD, Wu GD. A role for bacterial urease in gut dysbiosis and Crohn’s disease. Sci Transl Med, 9(416), Nov 15, 2017. PMID: 29141885.
Hyams JS, Davis S, Mack DR, Boyle B, Griffiths AM, LeLeiko NS, Sauer CG, Keljo DJ, Markowitz J, Baker SS, Rosh J, Baldassano RN, Patel A, Pfefferkorn M, Otley A, Heyman M, Noe J, Oliva-Hemker M, Rufo P, Strople J, Ziring D, Guthery SL, Sudel B, Benkov K, Wali P, Moulton D, Evans J, Kappelman MD, Marquis A, Sylvester FA, Collins MH, Venkateswaran S, Dubinsky M, Tangpricha V, Spada KL, Britt A, Saul B, Gotman N, Wang J, Serrano J, Kugathasan S, Walters T, Denson LA. Factors associated with early outcomes following standardised therapy in children with ulcerative colitis (PROTECT): A multicenter inception cohort study. Lancet Gastroenterol Hepatol, 2(12):855-868, Dec 2017. Epub 2017 Sep 20. PMID: 28939374. PMCID: PMC5695708 [available 2018-12-01].
Bertha M, Vasantharoopan A, Kumar A, Bruce BB, Prince J, Hofmekler T, Okou D, Chopra P, Wang G, Sauer C, Landers CJ, Hussain SZ, Cross RK, Baldassano RN, Kappelman MD, Katz J, Alexander JS, Kirschner BS, Moulton DE, Osuntokun BO, Patel A, Saeed S, Klapproth JA, Dhere TA, Dubinsky MC, McGovern D, Kugathasan S. IBD serology and disease outcomes in African Americans with Crohn’s disease. Inflamm Bowel Dis, 24(1):209-216. Dec 19, 2017. PMID: 29272484.
2016
Cleynen I, Boucher G, Jostins L, Schumm LP, Zeissig S, Ahmad T, Andersen V, Andrews JM, Annese V, Brand S, Brant SR, Cho JH, Daly MJ, Dubinsky M, Duerr RH, Ferguson LR, Franke A, Gearry RB, Goyette P, Hakonarson H, Halfvarson J, Hov JR, Huang H, Kennedy NA, Kupcinskas L, Lawrance IC, Lee JC, Satsangi J, Schreiber S, Théâtre E, van der Meulen-de Jong AE, Weersma RK, Wilson DC; International Inflammatory Bowel Disease Genetics Consortium [Baldassano RN], Parkes M, Vermeire S, Rioux JD, Mansfield J, Silverberg MS, Radford-Smith G, McGovern DP, Barrett JC, Lees CW. Inherited determinants of Crohn’s disease and ulcerative colitis phenotypes: a genetic association study. Lancet, 9;387(10014):156-67, Jan 9 2016. doi: 10.1016/S0140-6736(15)00465-1. Epub 2015 Oct 18. PMID: 26490195.
Wang F, Kaplan JL, Gold BD, Bhasin MK, Ward NL, Kellermayer R, Kirschner BS, Heyman MB, Dowd SE, Cox SB, Dogan H, Steven B, Ferry GD, Cohen SA, Baldassano RN, Moran CJ, Garnett EA, Drake L, Otu HH, Mirny LA, Libermann TA, Winter HS, Korolev KS. Detecting microbial dysbiosis associated with pediatric Crohn disease despite the high variability of the gut microbiota. Cell Rep, 4(4):945-55, Feb 2 2016, doi: 10.1016/j.celrep.2015.12.088. Epub 2016 Jan 21. PMID: 26804920.
Leonard MB, Shults J, Long J, Baldassano RN, Brown JK, Hommel K, Zemel BS, Mahboubi S, Whitehead KH, Herskovitz R, Lee D, Rausch J, Rubin CT. Effect of low-magnitude mechanical stimuli on bone density and structure in pediatric Crohn’s disease: A randomized placebo controlled trial. J Bone Miner Res, 31(6):1177-88, Jun 2016. doi: 10.1002/jbmr.2799. Epub 2016 March 31. PMID: 26821779.
DeBoer MD, Thayu M, Griffin LM, Baldassano RN, Denson LA, Zemel BS, Denburg MR, Agard HE, Herskovitz R, Long J, Leonard MB. Increases in sex hormones during anti-tumor necrosis factor α therapy in adolescents with Crohn’s disease. J Pediatr, 171:146-152, Apr 2016. E1-2. doi: 10.1016/j.jpeds.2016.01.003. PMID: 26873656.
Withers DR, Hepworth MR, Wang X, Mackley EC, Halford EE, Dutton EE, Marriott CL, Brucklacher-Waldert V, Veldhoen M, Kelsen J, Baldassano RN, Sonnenberg GF. Transient inhibition of ROR-yt therapeutically limits intestinal inflammation by reducing TH17 cells and preserving group 3 innate lymphoid cells. Nat Med, 22(3):319-23, March 2016. doi: 10.1038/nm.4046. PMID: 26878233.
Turner D, Levine A, Walters TD, Focht G, Otley A, López VN, Koletzko S, Baldassano RN, Mack D, Hyams J, Griffiths AM. Which PCDAI version best reflects intestinal inflammation in pediatric Crohn’s disease? J Pediatr Gastroenterol Nutr, 64(2):254-260, Feb 2017.. PMID: 27050050.
Stein R, Lee D, Leonard MB, Thayu M, Denson LA, Chuang E, Herskovitz R, Kerbowski T, Baldassano RN. Serum infliximab, antidrug antibodies, and tumor necrosis factor predict sustained response in pediatric Crohn’s disease. Inflamm Bowel Dis, 22(6):1370-7, Jun 2016. PMID: 27057683.
Li J, Wei Z, Chang X, Cardinale CJ, Kim CE, Baldassano RN, Hakonarson H, and the International IBD Genetics Consortium. Pathway-based genome-wide association studies reveal the association between growth factor activity and inflammatory bowel disease. Inflamm Bowel Dis, 22(7):1590-51, Jul 2016. PMID: 27104816.
Conrad MA, Stein RE, Maxwell EC, Albenberg L, Baldassano RN, Dawany N, Grossman AB, Mamula P, Piccoli DA, Kelsen JR. Vedolizumab therapy in severe pediatric inflammatory bowel disease. Inflamm Bowel Dis, 22(10): 2425-31, Oct 2016. PMID 27598742.
2015
Kelsen Judith R, Dawany Noor, Martinez Alejandro, Grochowski Christopher M, Maurer Kelly, Rappaport Eric, Piccoli David A, Baldassano Robert N, Mamula Petar, Sullivan Kathleen E, Devoto Marcella: Erratum to: A de novo whole gene deletion of XIAP detected by exome sequencing analysis in very early onset inflammatory bowel disease: a case report. BMC gastroenterology 15(1): 179, Dec 2015.
Kelsen Judith R, Dawany Noor, Moran Christopher J, Petersen Britt-Sabina, Sarmady Mahdi, Sasson Ariella, Pauly-Hubbard Helen, Martinez Alejandro, Maurer Kelly, Soong Joanne, Rappaport Eric, Franke Andre, Keller Andreas, Winter Harland S, Mamula Petar, Piccoli David, Artis David, Sonnenberg Gregory F, Daly Mark, Sullivan Kathleen E, Baldassano Robert N, Devoto Marcella: Exome Sequencing Analysis Reveals Variants in Primary Immunodeficiency Genes in Patients With Very Early Onset Inflammatory Bowel Disease. Gastroenterology 149(6): 1415-24, Nov 2015 Notes: doi. 10.1053/j.gastro.2015.07.006. Epub 2015 July 17.
Kelsen Judith R, Dawany Noor, Martinez Alejuandro, Grochowski Christopher M, Maurer Kelly, Rappaport Eric, Piccoli David A, Baldassano Robert N, Mamula Petar, Sullivan Kathleen E, Devoto Marcella: A de novo whole gene deletion of XIAP detected by exome sequencing analysis in very early onset inflammatory bowel disease: a case report. BMC gastroenterology 15: 160, Nov 2015.
Huang Chengrui, Haritunians Talin, Okou David T, Cutler David J, Zwick Michael E, Taylor Kent D, Datta Lisa W, Maranville Joseph C, Liu Zhenqiu, Ellis Shannon, Chopra Pankaj, Alexander Jonathan S, Baldassano Robert N, Cross Raymond K, Dassopoulos Themistocles, Dhere Tanvi A, Duerr Richard H, Hanson John S, Hou Jason K, Hussain Sunny Z, Isaacs Kim L, Kachelries Kelly E, Kader Howard, Kappelman Michael D, Katz Jeffrey, Kellermayer Richard, Kirschner Barbara S, Kuemmerle John F, Kumar Archana, Kwon John H, Lazarev Mark, Mannon Peter, Moulton Dedrick E, Osuntokun Bankole O, Patel Ashish, Rioux John D, Rotter Jerome I, Saeed Shehzad, Scherl Ellen J, Silverberg Mark S, Silverman Ann, Targan Stephan R, Valentine John, Wang Ming-Hsi, Simpson Claire L, Bridges S Louis, Kimberly Robert P, Rich Stephen S, Cho Judy H, Di Rienzo Anna, Kao Linda W H, McGovern Dermot P B, Brant Steven R, Kugathasan Subra: Characterization of Genetic Loci That Affect Susceptibility to Inflammatory Bowel Diseases in African Americans. Gastroenterology 149(6): 1575-86, Nov 2015 Notes: doi: 10.1053/j.gastro.2015.07.065. Epub 2015 Aug 14.
Li Yun R, Zhao Sihai D, Li Jin, Bradfield Jonathan P, Mohebnasab Maede, Steel Laura, Kobie Julie, Abrams Debra J, Mentch Frank D, Glessner Joseph T, Guo Yiran, Wei Zhi, Connolly John J, Cardinale Christopher J, Bakay Marina, Li Dong, Maggadottir S Melkorka, Thomas Kelly A, Qui Haijun, Chiavacci Rosetta M, Kim Cecilia E, Wang Fengxiang, Snyder James, Flatø Berit, Førre Øystein, Denson Lee A, Thompson Susan D, Becker Mara L, Guthery Stephen L, Latiano Anna, Perez Elena, Resnick Elena, Strisciuglio Caterina, Staiano Annamaria, Miele Erasmo, Silverberg Mark S, Lie Benedicte A, Punaro Marilynn, Russell Richard K, Wilson David C, Dubinsky Marla C, Monos Dimitri S, Annese Vito, Munro Jane E, Wise Carol, Chapel Helen, Cunningham-Rundles Charlotte, Orange Jordan S, Behrens Edward M, Sullivan Kathleen E, Kugathasan Subra, Griffiths Anne M, Satsangi Jack, Grant Struan F A, Sleiman Patrick M A, Finkel Terri H, Polychronakos Constantin, Baldassano Robert N, Luning Prak Eline T, Ellis Justine A, Li Hongzhe, Keating Brendan J, Hakonarson Hakon: Genetic sharing and heritability of paediatric age of onset autoimmune diseases. Nature communications 6: 8442, Oct 2015.
Lewis James D, Chen Eric Z, Baldassano Robert N, Otley Anthony R, Griffiths Anne M, Lee Dale, Bittinger Kyle, Bailey Aubrey, Friedman Elliot S, Hoffmann Christian, Albenberg Lindsey, Sinha Rohini, Compher Charlene, Gilroy Erin, Nessel Lisa, Grant Amy, Chehoud Christel, Li Hongzhe, Wu Gary D, Bushman Frederic D: Inflammation, Antibiotics, and Diet as Environmental Stressors of the Gut Microbiome in Pediatric Crohn's Disease. Cell host & microbe 18(4): 489-500, Oct 2015.
Liu Jimmy Z, van Sommeren Suzanne, Huang Hailiang, Ng Siew C, Alberts Rudi, Takahashi Atsushi, Ripke Stephan, Lee James C, Jostins Luke, Shah Tejas, Abedian Shifteh, Cheon Jae Hee, Cho Judy, Daryani Naser E, Franke Lude, Fuyuno Yuta, Hart Ailsa, Juyal Ramesh C, Juyal Garima, Kim Won Ho, Morris Andrew P, Poustchi Hossein, Newman William G, Midha Vandana, Orchard Timothy R, Vahedi Homayon, Sood Ajit, Sung Joseph J Y, Malekzadeh Reza, Westra Harm-Jan, Yamazaki Keiko, Yang Suk-Kyun, Barrett Jeffrey C, Franke Andre, Alizadeh Behrooz Z, Parkes Miles, B K Thelma, Daly Mark J, Kubo Michiaki, Anderson Carl A, Weersma Rinse K: Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nature genetics 47(9): 979-86, Sep 2015.
Kelsen Judith R, Baldassano Robert N, Artis David, Sonnenberg Gregory F: Maintaining intestinal health: the genetics and immunology of very early onset inflammatory bowel disease. Cellular and molecular gastroenterology and hepatology 1(5): 462-476, Sep 2015.
Li Yun R, Li Jin, Zhao Sihai D, Bradfield Jonathan P, Mentch Frank D, Maggadottir S Melkorka, Hou Cuiping, Abrams Debra J, Chang Diana, Gao Feng, Guo Yiran, Wei Zhi, Connolly John J, Cardinale Christopher J, Bakay Marina, Glessner Joseph T, Li Dong, Kao Charlly, Thomas Kelly A, Qiu Haijun, Chiavacci Rosetta M, Kim Cecilia E, Wang Fengxiang, Snyder James, Richie Marylyn D, Flatø Berit, Førre Øystein, Denson Lee A, Thompson Susan D, Becker Mara L, Guthery Stephen L, Latiano Anna, Perez Elena, Resnick Elena, Russell Richard K, Wilson David C, Silverberg Mark S, Annese Vito, Lie Benedicte A, Punaro Marilynn, Dubinsky Marla C, Monos Dimitri S, Strisciuglio Caterina, Staiano Annamaria, Miele Erasmo, Kugathasan Subra, Ellis Justine A, Munro Jane E, Sullivan Kathleen E, Wise Carol A, Chapel Helen, Cunningham-Rundles Charlotte, Grant Struan F A, Orange Jordan S, Sleiman Patrick M A, Behrens Edward M, Griffiths Anne M, Satsangi Jack, Finkel Terri H, Keinan Alon, Prak Eline T Luning, Polychronakos Constantin, Baldassano Robert N, Li Hongzhe, Keating Brendan J, Hakonarson Hakon: Meta-analysis of shared genetic architecture across ten pediatric autoimmune diseases. Nature medicine Aug 2015.
Lee Dale, Baldassano Robert N, Otley Anthony R, Albenberg Lindsey, Griffiths Anne M, Compher Charlene, Chen Eric Z, Li Hongzhe, Gilroy Erin, Nessel Lisa, Grant Amy, Chehoud Christel, Bushman Frederic D, Wu Gary D, Lewis James D: Comparative Effectiveness of Nutritional and Biological Therapy in North American Children with Active Crohn's Disease. Inflammatory bowel diseases 21(8): 1786-93, Aug 2015.
Kelsen Judith, Bittinger Kyle, Pauly-Hubbard Helen, Posivak Leah, Grunberg Stephanie, Baldassano Robert, Lewis James D, Wu Gary D, Bushman Frederic D: Alterations of the Subgingival Microbiota in Pediatric Crohn's Disease Studied Longitudinally in Discovery and Validation Cohorts. Inflammatory bowel diseases Aug 2015.
Chehoud Christel, Albenberg Lindsey G, Judge Colleen, Hoffmann Christian, Grunberg Stephanie, Bittinger Kyle, Baldassano Robert N, Lewis James D, Bushman Frederic D, Wu Gary D: Fungal Signature in the Gut Microbiota of Pediatric Patients With Inflammatory Bowel Disease. Inflammatory bowel diseases 21(8): 1948-56, Aug 2015.
Hommel Kevin A, Gray Wendy N, Hente Elizabeth, Loreaux Katherine, Ittenbach Richard F, Maddux Michele, Baldassano Robert, Sylvester Francisco, Crandall Wallace, Doarn Charles, Heyman Melvin B, Keljo David, Denson Lee A: The Telehealth Enhancement of Adherence to Medication (TEAM) in pediatric IBD trial: Design and methodology. Contemporary clinical trials 43: 105-13, Jul 2015.
Cutler David J, Zwick Michael E, Okou David T, Prahalad Sampath, Walters Thomas, Guthery Stephen L, Dubinsky Marla, Baldassano Robert, Crandall Wallace V, Rosh Joel, Markowitz James, Stephens Michael, Kellermayer Richard, Pfefferkorn Marian, Heyman Melvin B, LeLeiko Neal, Mack David, Moulton Dedrick, Kappelman Michael D, Kumar Archana, Prince Jarod, Bose Promita, Mondal Kajari, Ramachandran Dhanya, Bohnsack John F, Griffiths Anne M, Haberman Yael, Essers Jonah, Thompson Susan D, Aronow Bruce, Keljo David J, Hyams Jeffrey S, Denson Lee A, Kugathasan Subra: Dissecting Allele Architecture of Early Onset IBD Using High-Density Genotyping. PloS one 10(6): e0128074, Jun 2015.
Griffin LM, Thayu M, Baldassano RN, DeBoer MD, Zemel BS, Denburg MR, Denson LA, Shults J, Herskovitz R, Long J, Leonard MB. Improvements in bone density and structure during anti-TNF-α therapy in pediatric Crohn’s disease. J Clin Endocrinol Metab, April 28, 2015. jc20144152 [Epub ahead of print]. PMID: 25919459.
Hepworth MR, Fung TC, Masur SH, Kelsen JR, McConnell FM, Dubrot J, Withers DR, Hugues S, Farrar MA, Reith W, Eberl G, Baldassano RN, Laufer TM, Elson CO, Sonenberg GF. Group 3 innate lymphoid cells mediate intestinal selection of commensal bacteria-specific CD4+ Tcells. Science, April 23, 2015. pii:aaa4812. [Epub head of print]. PMID: 25908663.
Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA. Corrigendum. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest, 125(3):1363, March 2 2015. doi: 10.1172/JC179657. Epub March 2 2015. PMID: 25729854.
Lee D, Albenberg L, Compher C, Baldassano RN, Piccoli D, Lewis JD, Wu GD. Diet in the pathogenesis and treatment of inflammatory bowel diseases. Gastroenterology, 15 Jan 2015. Pii: S0016-5085(15)00069-4. Doi: 10.1053/j.gastro.2015.01.007. [Epub ahead of print]. PMID: 25597840.
Gray WN, Boyle SL, Graef DM, Janicke DM, Jolley CD, Denson LA, Baldassano RN, Hommel KA. Health-related quality of life in youth with Crohn’s disease. J Pediatr Gastroenterol Nutr, 5 Jan 2015. [Epub ahead of print]. PMID: 25564807.
Goyette P, Boucher G, Mallon D, Ellinghaus E, Jostins L, Huang H, Ripke S, Gusareva ES, Annese V, Hauser SL, Oksenberg JR, Thomsen I, Leslie S; International Inflammatory Bowel Disease Genetics Consortium; Australia and New Zealand IBDGC, Belgium IBD Genetics Consortium; Italian Group for IBD Genetic Consortium, NIDDK Inflammatory Bowel Disease Genetics Consortium; United Kingdom IBDGC; Wellcome Trust Case Control Consortium; Quebec IBD Genetics Consortium; Daly MJ, Van Steen K, Duerr RH, Barrett JC, McGovern DP, Schumm LP, Traherne JA, Carrington MN, Kosmoliaptsis V, Karlsen TH, Franke A, Rioux JD, [Collaborators 168: Baldassano RN]. High-density mapping of the MHC identifies a shared role for HLA-DRB1*01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis. Nat Genet, 47(2):172-9, Feb 2015. doi: 10.1038/ng.3176. Epub Jan 5 2015. PMID: 25559196.
2014
Kelsen JR, Grossman AB, Pauly-Hubbard H, Gupta K, Baldassano RN, Mamula P. Infliximab therapy in pediatric patients 7 years of age and younger. J Pediatr Gastroenterol Nutr, 59(6):758-62,Dec 2014. doi: 10.1097/MPG. PMID: 25419596.
Turner D, Doveh E, Cohen A, Wilson ML, Grossman AB, Rosh JR, Lu Y, Bousvaros A, Deslandres C, Noble A, Baldassano RN, Levine A, Lerner A, Wilson DC, Griffths AM. Efficacy of oral methotrexate in paediatric Crohn’s disease: a multicenter propensity score study. Gut, Nov 21, 2014, pii:gutjnl-2014-307964. doi: 10.1136/gutjnl-2014-307964. [Epub ahead of print]. PMID: 25416066.
Haberman Y, Tickle TL, Dexheimer PJ, Kim MO, Tang D, Karns R, Baldassano RN, Noe JD, Rosh J, Markowitz J, Heyman MB, Griffiths AM, Crandall WV, Mack DR, Baker SS, Huttenhower C, Keljo DJ, Hyams JS, Kugathasan S, Walters TD, Aronow B, Xavier RJ, Gevers D, Denson LA. Pediatric Crohn disease patients exhibit specific ileal transcriptome and microbiome signature. J Clin Invest, 124(8):3617-33, Aug 2014, doi: 10.1172/JC175436. Epub Jul 8 2014. Erratum in: J Clin Invest,125(3):1363, March 2, 2015. PMID: 25003194.
Boyle BM, Kappelman MD, Colletti RB, Baldassano RN, Milov DE, Crandall WV. Routine use of thiopurines in maintaining remission in pediatric Crohn’s disease. World J Gastroenterol, 20(27):9185-90, July 21, 2014, doi. 10.3748/wjg.v20.i27.9185. PMID 25083093.
Albenberg L, Esipova TV, Judge CP, Bittinger K, Chen J, Laughlin A, Grunberg S, Baldassano RN, Lewis JD, Li H, Thom SR, Bushman FD, Vinogradov SA, Wu GD. Correlation between intraluminal oxygen gradient and radial partitioning of intestinal microbiota in humans and mice. Gastroenterology, Jul 18 2014, pii: S0016-5085(14)00916-0, doi: 10.1053/j.gastro.2014.07.020. [Epub ahead of print]. PMID: 25046162.
Minar P, Haberman Y, Jurickova I, Wen T, Rothenberg ME, Kim MO, Saeed SA, Baldassano RN, Stephens M, Markowitz J, Rosh J, Crandall WV, Heyman MB, Mack DR, Griffiths AM, Baker SS, Hyams JS, Kugathasan S, Denson LA. Utility of neutrophil Fcy receptor l (CD64) index as a biomarker for mucosal inflammation in pediatric Crohn’s disease. Inflamm Bowel Dis, 20(6):1037-48, June 2014. PMID: 24788216.
Cardinale CJ, Wei Z, Li J, Zhu J, Gu M, Baldassano RN, Grant SF, Hakonarson H: Transcriptome profiling of human ulcerative colitis mucosa reveals altered expression of pathways enriched in genetic susceptibility loci. PLoS One, 9(5): May 1, 2014, e96153.doi:10.1371/journal.pone.0096153. eCollection 2014. PMID 24788701; PMCID: PMC4006814.
Tsampalieros A, Berkenstock MK, Zemel BS, Griffin L, Shults J, Burnham JM, Baldassano RN, Leonard MB. Changes in trabecular bone density in incident pediatric Crohn disease: A comparison of imaging methods. Osteoporosis Int., 25(7):1875-83, Jul 2014, doi: 10.1007/s00198-014-2701-x. Epub 2014 April 24. PMID: 24760243.
Gevers D, Kugathasan S, Denson LA, Vazquez-Baeza Y, Van Treuren W…Baldassano RN, et al. The treatment-naïve microbiome in new-onset Crohn’s disease. Cell Host Microbe, 15(3):382-392, March 12, 2014. doi:10.1016/j.chom.2014.02.005. PMID: 24629344.
Augustine MV, Leonard MB, Thayu M, Baldassano RN, et al. Changes in Vitamin-D-related mineral metabolism after induction with anti-tumor necrosis factor-α therapy in Crohn’s disease. J Clin Endocrinol Metab, 99(6):E991-8, Jun 2014, doi: 10.1210/jc.2013-3846. Epub March 11 2014. PMID: 24617709.
Zahm AM, Hand NJ, Tsoucas DM, Le Guen Cl, Baldassano RN, Friedman JR. Rectal microRNAs are perturbed in pediatric inflammatory bowel disease of the colon. J Crohns Colitis, March 6, 2014, pii: S1873-9946(14)00061-0, doi: 10.1016/j.crohns.2014.02.012. [Epub ahead of print]. PMID: 24613022.
Fish S, Baldassano RN. Can we change the natural history of Crohn’s disease? “Are we under- or mistreating patients at the time of presentation?” Dig Dis, 32(4):364-9, 2014, doi 10.1159/000358139. Epub Jun 23 2014. PMID: 24969281.
Walters TD, Kim MO, Denson LA, Griffiths AM, Dubinsky M, Markowitz J, Baldassano RN…Hyams JS; PRO-KIIDS Research Group. Increased effectiveness of early therapy with anti-tumor necrosis factor-α vs an immunomodulator in children with Crohn’s disease. Gastroenterology, 146(2):383-91, Feb 2014. doi: 10.1053/J.gastro.2013.10.027. Epub 2013 Oct 23. PMID: 24162032.
Crandall WV, Baldassano RN, Bousvaros A, Denson LA, Gupta N, Mackner LM. NASPGHAN single-topic symposium: Discovering the future of pediatric IBD care. J Pediatric Gastroenterol Nutr, 58(1):130-8, Jan 2014. PMID: 24378522.
2013
Prosnitz Aaron R, Leonard Mary B, Shults Justine, Zemel Babette S, Hollis Bruce W, Denson Lee A, Baldassano Robert N, Cohen Aaron B, Thayu Meena: Changes in vitamin D and parathyroid hormone metabolism in incident pediatric Crohn's disease. Inflamm Bowel Dis Jan 2013.
Tsampalieros Anne, Lam Carol K L, Spencer Jenna C, Thayu Meena, Shults Justine, Zemel Babette S, Herskovitz Rita M, Baldassano Robert N, Leonard Mary B: Long Term Inflammation and Glucocorticoid Therapy Impair Skeletal Modeling during Growth in Childhood Crohn Disease. The Journal of Clinical Endocrinology and Metabolism May 2013 Notes: Epub ahead of print.
Wei Zhi, Wang Wei, Bradfield Jonathan, Li Jin, Cardinale Christopher, Frackelton Edward, Kim Cecilia, Mentch Frank, Van Steen Kristel, Visscher Peter M, Baldassano Robert N, Hakonarson Hakon: Large Sample Size, Wide Variant Spectrum, and Advanced Machine-Learning Technique Boost Risk Prediction for Inflammatory Bowel Disease. American Journal of Human Genetics May 2013 Notes: Epub ahead of print.
Gupta Kernika, Noble Angela, Kachelries Kelly E, Albenberg Lindsey, Kelsen Judith R, Grossman Andrew B, Baldassano Robert N: A novel enteral nutrition protocol for the treatment of pediatric Crohn's disease. Inflammatory Bowel Dis 19(7): 1374-8, Jun 2013.
Cardinale CJ, Kelsen J, Baldassano RN, Hakonarson H. Impact of exome sequencing in inflammatory bowel disease. World J Gastroenterol, 19(40):6721-9, Oct 28, 2013. doi:10.3748/wjg.v19.i40.6721. PMID: 24187447; PMCID: PMC3812471.
Cardinale CJ, Wei Z, Panossian S, Wang F, Kim CE, Mentch FD, Chiavacci RM, Kachelries KE, Pandey R, Grant SFA, Baldassano RN, Hakonarson H. Targeted resequencing identifies defective variants of decoy receptor 3 in pediatric-onset inflammatory bowel disease. Genes Immun, 14(7):447-52, Oct 2013. doi:10.1038/gene.2013.43. Epub 2013 Aug 22. PMID: 23965943.
Beaudoin M, Goyette P, Boucher G, Lo KS, Rivas MA, Stevens C, Alikashani A…International IBD Genetics Consortium [Baldassano RN]. Deep resequencing of GWAS loci identifies rare variants in CARD9, IL23R and RNF186 that are associated with ulcerative colitis. PLoS Genet, 9(9):e1003723, Sept 12, 2013. doi: 10.1371/journal.pgen.1003723. Epub2013 Sept 12. PMID: 24068945.
Tsampalieros A, Lam CK, Spencer JC, Thayu M, Shults J, Zemel BS, Herskovitz RM, Baldassano RN, Leonard MB. Long-term inflammation and glucocorticoid therapy impair skeletal modeling during growth in childhood Crohn disease. J Clin Endocrinol Metab, 98(8):3438-45, Aug 2013. doi: 10.1210/jc.2013-1631. Epub 2013 May 20. PMID: 23690309.
Wei Z, Wang W, Bradfield J, Li J, Cardinale C, Frackelton E, Kim C, Mentch F, Van Steen K, Visscher PM, Baldassano RN, Hakonarson H; The International IBD Genetics Consortium, Large sample size, wide variant spectrum, and advanced machine-learning technique boost risk prediction for inflammatory bowel disease. Am J Hum Genet, 92(6):1008-12, Jun 6, 2013. doi: 10.1016/j.ajhg.2013.05.002 Epub 2013 May 23. PMID: 23731541. PMCID:
2012
Crandall Wallace V, Margolis Peter A, Kappelman Michael D, King Eileen C, Pratt Jesse M, Boyle Brendan M, Duffy Lynn F, Grunow John E, Kim Sandra C, Leibowitz Ian, Schoen Bess T, Colletti Richard B: Improved outcomes in a quality improvement collaborative for pediatric inflammatory bowel disease. Pediatrics 129(4): e1030-41, Apr 2012.
Gray Wendy N, Denson Lee A, Baldassano Robert N, Hommel Kevin A: Treatment adherence in adolescents with inflammatory bowel disease: the collective impact of barriers to adherence and anxiety/depressive symptoms. Journal of Pediatric Psychology 37(3): 282-91, Apr 2012.
Hyams Jeffrey, Damaraju Lakshmi, Blank Marion, Johanns Jewel, Guzzo Cynthia, Winter Harland S, Kugathasan Subra, Cohen Stanley, Markowitz James, Escher Johanna C, Veereman-Wauters Gigi, Crandall Wallace, Baldassano Robert, Griffiths Anne: Induction and maintenance therapy with infliximab for children with moderate to severe ulcerative colitis. Clinical Gastroenterology and Hepatology: The official clinical practice journal of the American Gastroenterological Association 10(4): 391-9.e1, Apr 2012.
Yatsunenko Tanya, Rey Federico E, Manary Mark J, Trehan Indi, Dominguez-Bello Maria Gloria, Contreras Monica, Magris Magda, Hidalgo Glida, Baldassano Robert N, Anokhin Andrey P, Heath Andrew C, Warner Barbara, Reeder Jens, Kuczynski Justin, Caporaso J Gregory, Lozupone Catherine A, Lauber Christian, Clemente Jose Carlos, Knights Dan, Knight Rob, Gordon Jeffrey I: Human gut microbiome viewed across age and geography. Nature 486(7402): 222-7, Jun 2012.
Hyams Jeffrey S, Griffiths Anne, Markowitz James, Baldassano Robert N, Faubion William A, Colletti Richard B, Dubinsky Marla, Kierkus Jaroslaw, Rosh Joel, Wang Yaqin, Huang Bidan, Bittle Barry, Marshall Michael, Lazar Andreas: Safety and Efficacy of Adalimumab for Moderate to Severe Crohn's Disease in Children. Gastroenterology Aug 2012.
Horton DB, Sherry DD, Baldassano RN, Weiss PF. : Enthesitis is an extraintestinal manifestation of inflammatory bowel disease. Ann Paediatr Rheum 1(4): 214-221, 2012.
Books
Mamula P, Grossman AB, Baldassano RN, Kelsen JR, Markowitz JE (Eds.): Pediatric Inflammatory Bowel Disease 3rd Edition, Springer International Publishing, New York, NY, 2017. ISBN 978-3-319-49213-1.
Mamula P, Markowitz J, Baldassano RN (eds): Pediatric Inflammatory Bowel Disease. Pediatric Inflammatory Bowel Disease 2nd Edition. Mamula P, Markowitz J, Baldassano RN (eds.). Springer Science+Business Media, New York, NY, 2012.
Mamula P, Markowitz J, Baldassano RN (eds): Pediatric Inflammatory Bowel Disease. Pediatric Inflammatory Bowel Disease. Mamula P, Markowitz J, Baldassano RN (eds.). Springer Science+Business Media, New York, NY, 2008.
Chapters
2017
Stein R, Baldassano RN: Dietary Therapies for Inflammatory Bowel Disease, in Mamula P, Grossman AB, Baldassano RN, Kelsen JR, Markowitz JE (Eds.). Pediatric Inflammatory Bowel Disease 3rd Edition, Springer International Publishing, New York, NY, Part IV Medical Therapy, Chapter 38, page 473-485, 2017. ISBN 978-3-319-49213-1.
2015
Grossman AB, Baldassano RN: Inflammatory Bowel Disease Nelson Textbook of Pediatrics, 2-Volume Set, 20th Edition. Kliegman RM, Stanton B, St. Geme J, Schor NF (eds.). Elsevier, Inc: Philadelphia, PA, 2(Part XVIII, Sec 4, Chapter 336), May 2015 Notes: ISBN-13: 978-1455775668; ISBN-10: 1455775665.
Grossman AB, Baldassano RN: Eosinophilic Gastroenteritis. Nelson Textbook of Pediatrics, 2-Volume Set, 20th Edition. Kliegman RM, Stanton B, St. Geme J, Schor NF (Eds) (eds.). Elsevier, Inc, Philadelphia, PA, 2(Part XVIII, Sec 4, Chapter 337), May 2015 Notes: ISBN-13: 978-1455775668; ISBN-10: 1455775665.
2014
Albenberg L, Baldassano RN, Kelsen J: Pediatric Issues in Treating Ulcerative Colitis. Medical Therapy of Ulcerative Colitis. Lichtenstein GR (eds.). Springer, NY, Page: 281-290, Oct 2014 Notes: Chapter 25.
2013
Albenberg L, Baldassano RN: What is the Current Understanding of the Etiology of Inflammatory Bowel Disease? Curbside Consultation in Pediatric GI: 49 Clinical Questions. Rosh J, Bousvaros A (eds.). Slack, Inc., Thorofare, NJ, 2013 Notes: in press.
Albenberg L, Kelsen J, Baldassano RN: Pediatric Issues in Treating Ulcerative Colitis. Medical Therapy of Ulcerative Colitis. Lichtenstein GR (eds.). Springer, NY, 2013 Notes: In press.
Grossman AB, Baldassano RN: Inflammatory Bowel Disease. Nelson Textbook of Pediatrics, 20th Edition. Kliegman R, Stanton B, St. Geme J, Schor N. (eds.). Elsevier, Inc., Philadelphia, PA, Chapter 328, 2013 Notes: submitted.
Grossman AB, Baldassano RN.: Eosinophilic Gastroenteritis. Nelson Textbook of Pediatrics, 20th Edition. Kliegman R, Stanton B, St. Geme J, Schor N. (eds.). 2013 Notes: submitted.
Kelsen J, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Crohn's Disease. The Complete Guide to Medical Management, 2nd Edition. Lichtenstein GR (eds.). 2013 Notes: in press.
2011
Ghanem LR, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Inflammatory Bowel Disease. Crohn's Disease: The Complete Guide to Medical Management. Lichtenstein GR (eds.). Slack, Inc., Thorofare, NJ, Apr 2011 Notes: Chapter 5.
Ghanem LR, Baldassano RN: Pediatric Considerations in Medical Therapy in Patients with Inflammatory Bowel Disease. Ulcerative Colitis: The Complete Guide to Medical Management. Lichtenstein GR (eds.). Slack, Inc., Thorofare, NJ, Apr 2011 Notes: Chapter 5.
Kelsen J, Hunter A, Baldassano RN: Pediatric Therapies in Inflammatory Bowel Disease. Advanced Therapy in Inflammatory Bowel Disease, 3rd Edition Vol 2: IBD and Crohn's Disease, Crohn's Disease Therapy. Bayless TM, Hanauer SB (eds.). People's Medical Publishing House-USA August 2011.
Grossman AB and Baldassano RN: Eosinophilic Gastroenteritis. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 329), 1304, 2011.
Grossman AB and Baldassano RN: Inflammatory Bowel Disease. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328), 1294-1295, 2011.
Grossman AB and Baldassano RN: Chronic Ulcerative Colitis. Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328.1), 1295-1300, 2011.
Grossman AB and Baldassano RN: Crohn Disease (Regional Enteritis, Regional Ileitis, Granulomatous Colitis). Nelson Textbook of Pediatrics, 19th Edition. Kliegman RM, Stanton BF, St. Geme JW, Schor NF, Behrman RE (eds.). Elsevier Saunders, Philadelphia, PA,(Chapter 328.2), 1300-1304, 2011.
2008
Grant SF, Baldassano RN, Hakonarson H: Classification of genetic profiles of Crohn's disease: a focus on the ATG16L1 gene. Expert Rev Mol Diagn 8(2): 199-207, Mar 2008.
Jacobstein D, Baldassano RN: Crohn Disease. The 5-Minute Pediatric Consult, 5th Edition. Schwartz MW (eds.). Lippincott Williams & Wilkins, Philadelphia, PA, Page: 228-229, 2008.
Jacobstein D, Baldassano RN: Inflammatory Bowel Disease. Pediatric Gastroenterology: The Requisites in Pediatrics. Liacouras CA, Piccoli DA (eds.). Mosby Elsevier, Philadelphia, PA, Page: 131-136, 2008.
2007
Kelsen J, Baldassano RN: Inflammatory Bowel Disease: The Difference between Children and Adults, Inflammatory Bowel Disease: Epidemiology, Pathogenesis, Diagnosis and Management 2007 Notes: Fiorcchi C, Katz J, Prantera C, Thomson A
2006
Jacobstein D, Baldassano RN. Pediatric considerations in medical therapy in patients with ulcerative colitis and Crohn’s disease. In: Lichtenstein GR, editor. Inflammatory bowel disease: The complete guide to medical management. Philadelphia: Slack Inc.; 2006.
2004
Mamula P, Markowitz J, Baldassano RN. Clinical features and natural history of pediatric inflammatory bowel disease (Chapter 21). In: Sartor RB, Sandborn WJ, editors. Kirsner’s inflammatory bowel diseases. 6th ed. Philadelphia: Saunders Company; 2004. p. 301-315.
Russo P, Brown K, Baldassano RN. Colitis in childhood (Chapter 5). In: Russo P, Rucchelli ED, Piccoli DA, editors. Pathology of pediatric gastrointestinal and liver disease. New York: Springer-Verlag Inc.; 2004. p. 100-127.
2003
Batres AL, Baldassano RN. Evaluation of the patient suspected of having inflammatory bowel disease (Chapter 16). In: Lichtenstein GR, editor. The clinical guide to inflammatory bowel disease. Thorofare: Slack Inc.; 2003. p. 315-324.
Batres AL, Baldassano RN. Special considerations for the pediatric and adolescent patients with inflammatory bowel disease (Chapter 17). In: Lichtenstein GR, editor. The clinical guide to inflammatory bowel disease. Thorofare: Slack Inc.; 2003. p. 325-342.
Mamula P, Markowitz J, Baldassano RN. Clinical features and natural history of pediatric inflammatory bowel disease In: Sandborn WJ, Sartor RB, editors. Kirsner’s inflammatory bowel disease. 6th ed. Philadelphia: Saunders Company; 2003.
1999
Baldassano RN. Crohn’s disease. In: Schwartz MW, editor. The 5-minute pediatric consult. 2nd ed. Baltimore: Williams & Wilkins; 1999. p. 290-291.
Baldassano RN. Ulcerative colitis. In: Schwartz MW, editor. The 5-minute pediatric consult. 2nd ed. Baltimore: Williams & Wilkins; 1999. p. 846-847
1997
Baldassano RN. Inflammatory bowel disease. In: Schwartz MW, Curry TA, Sargent AJ, Blum NJ, Fein J, editors. Pediatric primary care: a problem-oriented approach. 3rd ed. Philadelphia: Mosby-Year Book, Inc.; 1997. p. 543-547.
Kelsen J, Baldassano RN: Pediatric Considerations In Medical Therapy in Patients with Ulcerative Colitis. The Complete Guide to Medical Management, 2nd Edition. Lichtenstein GR (eds.). 2013 Notes: in press.