David A. Piccoli, MD
Areas of expertise: Advanced, technical, endoscopic diagnostic and therapeutic procedural gastroenterology, Alagille syndrome, Congenital, metabolic, genetic and inflammatory liver diseases, Crohn's disease, General diagnostic GI and Liver diseases, Liver disease, Inflammatory bowel disease (IBD), Second opinion consultation
Locations: Main Building
About David A. Piccoli, MD
David A. Piccoli, MD, is nationally-renown pediatric gastroenterologist, Chief of the Division of Gastroenterology, Hepatology and Nutrition.
Dr. Piccoli provides individualized and compassionate care for children with liver disorders, intestinal bowel disease, and other gastrointestinal conditions. Patients from around the world are referred to him for treatment and second opinions.
“My goal as a doctor, researcher and leader at CHOP is to incorporate the newest science and best technology to improve treatments and outcomes for all children,” Dr. Piccoli says. “That translates into every aspect of my work.”
Dr. Piccoli has a special interest in treating children with complex and chronic liver and bowel disorders that are often difficult to manage.
“Some children present with such a wide variety of symptoms that finding the right treatment for that specific child can be challenging,” Dr. Piccoli says. “There are so many moving pieces; it’s like a puzzle. And it’s very satisfying to me to find the right solution for that child.”
Education and experience
Dr. Piccoli earned his bachelor’s degree from Johns Hopkins University, Baltimore, MD, and his medical degree from Harvard Medical School, Boston, MA. He was a medical resident and later chief resident at what-was-then Children’s Hospital Medical Center in Boston, MA.
Dr. Piccoli completed a one-year clinical fellowship, followed by a two-year research fellowship, in pediatric gastroenterology and nutrition at The Children’s Hospital of Philadelphia. He became an attending physician and a member of the research faculty at CHOP in 1985.
In 1990, Dr. Piccoli was named director of clinical service for the Division of Gastroenterology and Nutrition. For the following eight years, he took on positions of increasing responsibility — section chief, medical director of the Pediatric Anorectal Continence Evaluation Program, associate chairman for outreach, and acting division chief.
In 1998, he was named division chief for the newly combined Division of Gastroenterology, Hepatology and Nutrition.
Making an impact
During Dr. Piccoli’s tenure as chief, the Division has nearly tripled in size, and has vastly expanded its clinical and research mission in gastrointestinal, hepatology and nutritional disorders. Support services in the division have expanded to include psychologists, social workers, dietitians, specialty nurses and others who provide care for children’s minds and bodies. At the same time, the Division has trained more than 100 fellows — the next generation of gastroenterologists.
Along with Dr. Piccoli’s role overseeing the Division of Gastroenterology, Hepatology and Nutrition, he has been active in a number of division programs. In 2004, he was named director — and later endowed chair — of the Fred and Suzanne Biesecker Pediatric Liver Center. He is also very active in the Center for Pediatric Inflammatory Bowel Disease.
Dr. Piccoli has also been a leader at CHOP, serving as executive sponsor of EpicCare CHOPLink implementation, and associate chairman for information technology for the Department of Pediatrics at CHOP. And, for more than 20 years, he has served as a professor of pediatrics at CHOP and the Perelman School of Medicine at the University of Pennsylvania.
Dr. Piccoli is also co-director of the HUP-CHOP Joint Center for Digestive, Liver and Pancreatic Diseases, a joint venture between CHOP, the Hospital of the University of Pennsylvania, and the Perelman School of Medicine at the University of Pennsylvania.
Research and recognition
Along with Dr. Piccoli’s active clinical practice and administrative duties, he continues to pursue research about metabolic and genetic liver disease, inflammatory bowel disease and rare gastrointestinal disorders. He is a member of the group that discovered Jagged1 and NOTCH2 as the primary causes of Alagille syndrome.
He has authored more than 90 papers, 40 chapters, 130 research abstracts and edited four books on areas of pediatric gastroenterology, hepatology and nutrition. He has also presented hundreds of lectures on conditions such as Alagille syndrome, inflammatory bowel disease, liver disease and viral hepatitis.
Dr. Piccoli has received a number of awards for his clinical care, teaching, mentorship, research and work with charitable foundations. He has served on local and national boards, including the North American Society for Pediatric Gastroenterology, Hepatology and Nutrition, the American Gastroenterological Association, the National Crohn's and Colitis Foundation of America, and the American Liver Foundation.
Titles
Chief, Division of Gastroenterology, Hepatology and Nutrition
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Certifications
Diplomate – National Board of Medical Examiners (NBME)
Pediatric Gastroenterology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Awards and Honors
2023, American Liver Foundation Leadership Award
2022, Philadelphia Magazine's Top Doctors in Gastroenterology, Hepatology and Nutrition
2016, Master Clinician, Academy of Master Clinicians, University of Pennsylvania
2012-2013, Pediatric Residency Faculty Honor Roll, The Children's Hospital of Philadelphia
2007, Faculty Mentor Award - The Children's Hospital of Philadelphia
2006, Beverly Mandell Physician Mentorship Award - APGNN
2006, Leadership Award, American Liver Foundation, Delaware Valley Chapter
2005-2012, Best Doctors, Philadelphia Magazine
2005, Outstanding Leadership Award, Crohn's and Colitis Foundation of America
2005, The Fred and Suzanne Biesecker Endowed Chair in Pediatrics
2004-2012, Castle Connolly America's Top Doctors
1999, Jean A. Cortner Divisional Teaching Award, The Children's Hospital of Philadelphia
1999, Klaus and Mary Hummeler Endowed Research Prize
1998, Komarov Research Prize (mentor), Philadelphia Gastrointestinal Research Forum
1996, The Best Doctors in America, American Health Magazine, Reader's Digest
1996, Christian R. and Mary F. Lindback Foundation Award for Distinguished Teaching, University of Pennsylvania
1996, Physician of the Year, Crohn's and Colitis Foundation, Delaware Valley Chapter
1994-1998, The Best Doctors in America Directory, Woodward White, Inc.
1994, Physician of the Year, American Liver Foundation, Delaware Valley Chapter
1993, Class of 1992 Teaching Award, University of Pennsylvania School of Medicine
1993, Faculty Teaching Award, The Children's Hospital of Philadelphia
1992, Blockley-Osler Award for Teaching Clinical Medicine, Blockley Section, College of Physicians of Philadelphia, University of Pennsylvania School of Medicine
1988, Komarov Research Prize (mentor), Philadelphia Gastrointestinal Research Forum
1986, Komarov Research Prize, Philadelphia Gastrointestinal Research Forum
1984, Fellows' Teacher of the Year Award, The Children's Hospital of Philadelphia
1983, Sidney Farber House Staff Award, The Children's Hospital, Boston, MA
1980, American Academy of Pediatrics Residency Fellowship
1975, High Honors, Departmental Honors (Biology), Johns Hopkins University
1974, Phi Beta Kappa, Johns Hopkins University
Leadership and Memberships
Memberships in professional organizations
1995-present, National Alagille Syndrome Alliance
1989-present, American Gastroenterological Association
1989-present, American Association for the Study of Liver Diseases
1988-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
1987-present, National Foundation for Ileitis and Colitis (NFIC)
1987-present, Crohn's and Colitis Foundation of America
1987-present, Crohn's and Colitis Foundation
Editorial and Academic Positions
Academic and Institutional Committees
2021-present, Transplant Executive Steering Committee
2021-present, Clinical Outcomes and Improvement Committee
2021-present, Frontier Program in Motility Disorders Internal Scientific Advisory Board
2016-present, Frontier Program In Inflammatory Bowel Disease, Internal Scientific Advisory Board
2013-present, Gastroenterology T32 Review Committee
2012-present, Scholarship Oversight Committee, CHOP Gastroenterology, Hepatology and Nutrition
2009-present, CHOP/CHCA Executive Committee
2009-present, HUP CHOP Joint Center for Digestive, Liver and Pancreatic Disease, Co-Director
2004-present, Biesecker Liver Center Internal Scientific Advisory Committee
1998-present, Executive Committee of the Medical Staff - Information Systems Committee
1998-present, CHOP Practice Association Claims Committee
1996-present, Board of Directors, Children's Health Care Associates (CHCA)
1996-present, Executive Committee, Department of Pediatrics, University of Pennsylvania
Research Interests
Alagille syndrome Bile duct disorders Inflammatory bowel diseases
Education & training
Undergraduate Degree
BA - Johns Hopkins University, Baltimore, MD
Medical Degree
MD - Harvard Medical School, Boston, MA
Internship
Pediatrics - Children's Hospital, Boston, MA
Residency
Pediatrics - Children's Hospital, Boston, MA (Chief Resident)
Fellowship
Research Fellow, Pediatric Gastroenterology and Nutrition - The Children's Hospital of Philadelphia, Philadelphia, PA
Clinical Fellow, Pediatric Gastroenterology and Nutrition - The Children's Hospital of Philadelphia, Philadelphia, PA
Publications
Publications
2023
Alanna Strong, Soumya Rao, Sandra von Hardenberg, Dong Li, Liza L. Cox, Paul C. Lee, Li Q. Zhang, Waheed Awotoye, Tamir Diamond, Jessica Gold, Catherine Gooch, Lord Jephthah Joojo Gowans, Hakon Hakonarson, Anne Hing, Kathleen Loomes, Nicole Martin, Mary L. Marazita, Tarja Mononen, David Piccoli, Rolph Pfundt, Salmo Raskin, Stephen W. Scherer, Nara Sobriera, Courtney Vaccaro, Xiang Wang, Deborah Watson, Rosanna Weksberg, Elizabeth Bhoj, Jeffrey C. Murray, Andrew C. Lidral, Azeez Butali, Michael F. Buckley, Tony Roscioli, David A. Koolen, Laurie H. Seaver, Cynthia A. Prows, Rolf W. Stottmann, Timothy C. Cox: A mutational hotspot in AMOTL1 defines a new syndrome of orofacial clefting, cardiac anomalies, and tall stature. American Journal of Medical Genetics Feb 2023 Notes: https://doi.org/10.1002/ajmg.a.63130.
2022
Brownell JN, Biko DM, Mamula P, Krishnamurthy G, Escobar F, Srinivasan A, Laje P, Piccoli DA, Pinto E, Smith CL, Dori Y: Dynamic Contrast Magnetic Resonance Lymphangiography Localizes Lymphatic Leak to the Duodenum in Protein-Losing Enteropathy. Journal of Pediatric Gastroenterology & Nutrition. 74(1): 38-45, Jan 2022 Notes: DOI: 10.1097/MPG.0000000000003287.
Vandriel SM, Li LT, She H, Wang JS, Gilbert MA, Jankowska I, Czubkowski P, Gliwicz-Miedzinska D, Gonzales EM, Jacquemin E, Bouligand J, Spinner NB, Loomes KM, Piccoli DA, D'Antiga L, Nicastro E, Sokal E, Demaret T, Ebel NH, Feinstein JA, Fawaz R, Nastasio S, Lacaille F, Debray D, Arnell H, Fischler B, Siew S, Stormon M, Karpen SJ, Romero R, Kim KM, Baek WY, Hardikar W, Shankar S, Roberts AJ, Evans HM, Jensen MK, Kavan M, Sundaram SS, Chaidez A, Karthikeyan P, Sanchez MC, Cavalieri ML, Verkade HJ, Lee WS, Squires JE, Hajinicolaou C, Lertudomphonwanit C, Fischer RT, Larson-Nath C, Mozer-Glassberg Y, Arikan C, Lin HC, Quintero Bernabeu J, Alam S, Kelly D, Carvalho E, Ferreira CT, Indolfi G, Quiros-Tejeira RE, Bulut P, Calvo PL, Onal Z, Valentino PL, Desai DM, Eshun J, Rogalidou M, Dezsofi A, Wiecek S, Nebbia G, Borges Pinto R, Wolters VM, Tamara ML, Zizzo AN, Garcia J, Schwarz K, Beretta M, Sandahl TD, Jimenez-Rivera C, Kerkar N, Brecelj J, Mujawar Q, Rock N, Busoms CM, Karnsakul W, Lurz E, Santos-Silva E, Blondet N, Bujanda L, Shah U, Thompson RJ, Hansen BE, Kamath BM, Global ALagille Alliance (GALA) Study Group.: Natural History of Liver Disease in a Large International Cohort of Children with Alagille syndrome: Results from The GALA Study. Hepatology Aug 2022.
2021
Schindler EA, Gilbert MA, Piccoli DA, Spinner NB, Krantz ID, Loomes KM: Alagille syndrome and risk for hepatocellular carcinoma: Need for increased surveillance in adults with mild liver phenotypes. American Journal of Human Genetics 185(3): 719-731, Mar 2021.
Rajagopalan R, Gilbert MA, McEldrew DA, Nassur JA, Loomes KM, Picoli DA, Krantz ID, Conlin LK, Spinner NB: Genome sequencing increases diagnostic yield in clinically diagnosed Alagille syndrome patients with previously negative test results. Genetic Medicine 23(3): 323-330, 2021.
2020
Gilbert MA, Schultz-Rogers L, Rajagapalan R, Rochowski CM, Wilkins BJ, Biswas S, Conlin LK, Fiorino KN, Dhamija R, Pack MA, Klee EW, Piccoli DA, Spinner NB: Protein-elongating mutations in MYH11 are implicated in a dominantly inherited smooth muscle dysmotility syndrome with severe esophageal, gastric, and intestinal disease. Human Mutation 41(5): 973-982, May 2020 Notes: doi: 10.1002/humu.23986.
Kindler JM, Mitchell EL, Piccoli DA, Grimberg A, Leonard MB, Loomes KM, Zemel BS: Bone geometry and microarchitecture deficits in children with Alagille syndrome. Bone(141), 115576, Dec 2020 Notes: DOI: 10.1016/j.bone.2020.115576.
2019
Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA, Spinner NB, Horn D, Shults J, Leonard MB, Grimberg A, Loomes KM: Pathologic lower extremity fractures in children with Alagille syndrome. European Radiology 29(10): 5190-5196, Oct 2019 Notes: DOI: 10.1007/s 00330-019-06112-z.
Biko DM, Smith CL, Otero HJ, Saul DW, Ammie M, DeWitt A, Glatz AC, Piccoli DA, Mamula P, Rome JJ, Dori Y: Intrahepatic dynamic contrast MR lymphangiography: initial experience with a new technique for the assessment of liver lymphatics. European Radiology 29(10): 5190-5196, Oct 2019 Notes: DOI: 101007/s00330-019-06112-z.
Gilbert MA, Bauer RC, Rajagopalan R, Grochowski CM, Chao G, McEldrew D, Nassur JA, Rand EB, Krock BL, Kamath BM, Krantz ID, Piccoli DA, Loomes KM, Spinner NB: Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification. Human Mutation 40(12): 2197-2220, Dec 2019 Notes: DOI: 10.1002/humu.23879.
Gilbert MA, Bauer RC, Rajagopalan R, Grochowski CM, Chao G, McEldrew D, Nassur JA, Rand EB, Krock BL, Kamath BM, Krantz ID, Piccoli DA, Loomes KM, Spinner NB : Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification. Human Mutation 40(12): 2197-2220, 2019 Notes: doi: 10.1002/humu.23879.
Gilbert MA, Bauer RC, Rajagopalan R, Grochowski CM, Chao G, McEldrew D. Nassur JA, Rand EB, Krock FL, Kamath BM, Krantz ID, Piccoli DA Loomes KM, Spinner NB: Alagille syndrome mutation update: Comprehensive overview of JAG1 and NOTCH2 mutation frequencies and insight into missense variant classification. Human Mutation 40(12): 2197-2220, Dec 2019 Notes: DOI: 10.1002/humu.23879.
2018
Sahn B, De Matos V, Stein R, Ruchelli E, Masur S, Klink AJ, Baldassano RN, Piccoli DA, Russo P, Mamula P: Histological features of ileitis differentiating pediatric Crohn diseasefrom ulcerative colitis with backwash ileitis Digestive and Liver Disease 50(2): 147-153, 2018.
2017
Ho DK, Levin AV, Anninger WV, Piccoli DA, Eagle RC Jr: Anterior chamber pathology in Alagille syndrome. Ocular Oncology Pathology 2(4): 270-275, Oct 2016 Notes: doi: 10.1159/0004446804.
Itkin M, Piccoli DA, Nadolski G, Rychik J, DeWitt A, Pinto E, Rome J, Dori Y: Protein-Losing Enteropathy in Patients With Congenital Heart Disease. Journal of the American College of Cardiology 69(24): 2929-2937, Jun 2017 Notes: DOI: 10.1016/j.jacc.2017.04.023
Scheers I, Palermo JJ, Freedman S, Wilschanski M, Shah U, Abu-El-Haija M, Barth B, Fishman DS, Gariepy C, Giefer MJ, Heyman MB, Himes RW, Husain SZ, Lin TK, Liu Q, Lowe M, Mascarenhas M, Morinville V, Ooi CY, Perito ER, Piccoli DA, Pohl JF, Schwarzenberg SJ, Troendle D, Werlin S, Zimmerman B, Uc A, Gonska T: Autoimmune Pancreatitis in Children: Characteristic Features, Diagnosis, and Management. [Review] American Journal of Gastroenterology 112(10): 1604-1611, Oct 2017 Notes: DOI: 10.1038/ajg.2017.85.
Itkin M, Piccoli DA, Nadolski G, Rychik J, DeWitt A, Pinto E, Rome J, Dori Y: Protein-losing enteropathy in patients with congenital heart disease. Journal of the American College of Cardiology 69: 2929-37, 2017 Notes: DOI: 10.1016/j.jacc.2017.04.023.
Tsai EA, Gilbert MA, Grochowski CM, Underkoffler LA, Meng H, Zhang X, Wang MM, Shitaye H., Hankenson KD, Piccoli D, Lin H, Kamath BM, Devoto M, Spinner NB, Loomes KM: THBS2 is a Candidate Modifier of Liver Disease Severity in Alagille Syndrome. Cellular and Molecular Gastroenterology and Hepatology Special Issue 2017 Page: 59-71, 2017 Notes: doi: 10.1016/j.jcmgh.2016.05.013.
2016
Waisbourd-Zinman O, Mamula P, Piccoli DA: Chromosome 10q23 Deletion Syndrome: An Overlap of Bannayan-Riley-Ruvalcaba Syndrome and Juvenile Polyposis Syndrome. J Paediatr Child Health 52(8), August 2016 Notes: doi:10:1111/jpc.13289.
Rajagopalan R, Grochowski CM, Gilbert MA, Falsey AM, Coleman K, Romero R, Loomes KM, Piccoli DA, Devoto M, Spinner NB: Compound heterozygous mutations in NEK8 in siblings with end-stage renal disease with hepatic and cardiac anomalies. Am J Med Genet A. doi: 10.1002/ajmg.a.37512.Epub 2015 Dec 24 (eds.). 170(3), Mar 2016.
Muir A, Surrey L, Kriegermeier A, Ahaikhkalil A, Piccoli DA: Severe Eosinophilic Gastroenteritis in a Crohn's Disease Patient Treated with Infliximab and Adalimumab. Am J Gastroenterol 111(3): 437-8, Mar 2016 Notes: doi: 10,1038/ajg.2015.438.
2015
Kelsen JR, Dawany N, Moran CJ, Petersen B-S, Sarmady M, Sasson A, Pauley-Hubbard H, Martinez A, Maurer K, Soong J, Rappaport E, Franke A, Keller A, Winter HS, Mamula P, Piccoli D, Artis D, Sonnenberg GF, Daly M, Sullivan KE, Baldassano RN, Devoto M: Exome Sequencing Analysis Reveals Variants in Primary Immunodeficiency Genes in Patients with Very Early Onset Inflammatory Bowel Disease. Gastroenterology 149(6): 1415-1424, November 2015.
Kelsen JR, Dawany N, Martinez A, Grochowski CM, Maurer K, Rappaport E, Piccoli DA, Baldassano RN, Mamula P, Sullivan KE, Devoto M: A de novo whole gene detected of XIAP detected by exome sequencing analysis in very early onset inflammatory bowel disease: a case report. BMC Gastroenterol 18(15), Nov 2015.
Mouzaki M, Bass LM, Sokol FJ, Piccoli DA, Quammie C, Loomes KM, Heubi JE, Hertel PM, Scheenstra R, Furuya K, Kutsch E, Spinner NB, Robbins KN, Venkat V, Rosenthal P, Beyene J, Baker A, Kamath BM: Early Life Predictive Markers of Liver Disease Outcome in an International, Multi-Centered Cohort of Children with Alagille Syndrome. Liver International 36(5): 755-60, July 2015.
Lee D, Albenberg L, Compher C, Baldassano R, Piccoli DA, Lewis JD, Wu GD: Diet in the Pathogenesis and Treatment of Inflammatory Bowel Disease. Gastroenterology 148(6): 1087-1106, May 2015.
Grochowski CM, Rajagopalan R, Falsey AM, Loomes KM, Piccoli DA, Krantz ID, Devoto M, Spinner NB: Exome sequencing reveals compound heterozygous mutations in ATP8B1 in a JAG1/NOTCH2 mutation-negative patient with clinically diagnosed Alagille syndrome Am J Med Genet A 167A(4): 891-3, Apr 2015 Notes: doi: 10.1002/ajmg.a.36946. Epub 2015 Mar 3.
2014
Baird LC, Smith ER, Ichord R, Piccoli DA, Bernard TJ, Spinner NB, Scott RM, Kamath BM: Moyamoya syndrome associated with Alagille syndrome: outcome after surgical revascularization. J Pediatr 166(2): 470-3, Feb 2015 Notes: doi: 10.1016/j.jpeds.2014.10.067. Epub 2014 Oct 30.
2013
Hsu E, Chugh P, Kronman M, Markowitz J, Piccoli D, Mamula P: Incidence of perforation in pediatric GI endoscopy and colonoscopy: an 11 year experience. Gastrointest Endosc 77(6): 960-966, 2013.
2012
Kamath BM, Podkameni G, Hutchinson AL, Leonard LD, Gerfen J, Krantz ID, Piccoli DA, Spinner NB, Loomes KM, Meyers K: Renal anomalies in Alagille Syndrome: A disease-defining feature. Amer J Med Gen 158A(1): 85-89, January 2012.
Kamath BM, Piccoli DA, Magee JC, Sokol RJ : Pancreatic insufficiency is not a prevalent problem in Alagille syndrome. Childhood Liver Disease Research and Education Network Journal of Pediatric Gastroenterology & Nutrition 55(5): 612-4, Nov 2012.
Kamath BM, Bauer RC, Loomes KM, Chao G, Gerfen J, Hutchinson A, Hardikar W, Hirschfield G, Jara P, Krantz ID, Lapunzina P, Leonard L, Ling S, Ng L, Hoang PL, Piccoli DA and Spinner NB: NOTCH2 Mutations in Alagille Syndrome. J Med Gen 49: 138-44, 2012.
2011
Friedlander JA, Loeben GS, Finnegan PK, Puma AE, Zhang X, de Zoeten EF, et al. A novel method to enhance informed consent: a prospective and randomised trial of form-based versus electronic assisted informed consent in paediatric endoscopy. J Med Ethics. 2011 Apr;37(4):194-200. Epub 2011 Jan 18. Cited in PubMed; PMID 21245476.
2010
Kamath BM, Loomes KM, Piccoli DA. Medical management of Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jun;50(6):580-6. Cited in PubMed; PMID 20479679.
Bales CB, Kamath BM, Munoz PS, Nguyen A, Piccoli DA, Spinner NB, Horn D, Shults J, Leonard MB, Grimberg A, Loomes KM. Pathologic lower extremity fractures in children with Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 Jul;51(1):66-70. Cited in PubMed; PMID 20453673.
Kamath BM, Munoz PS, Bab N, Baker A, Chen Z, Spinner NB, Piccoli DA. A longitudinal study to identify laboratory predictors of liver disease outcome in Alagille syndrome. J Pediatr Gastroenterol Nutr. 2010 May;50(5):526-30. Cited in PubMed; PMID 20421762.
Wang K, Baldassano R, Zhang H, Qu HQ, Imielinski M, Kugathasan S, et al. Comparative genetic analysis of inflammatory bowel disease and type 1 diabetes implicates multiple loci with opposite effects. Hum Mol Genet. 2010 May 15;19(10):2059-67. Epub 2010 Feb 22. Cited in PubMed; PMID 20176734.
2009
Kamath BM, Thiel BD, Gai X, Conlin LK, Munoz PS, Glessner J, et al. SNP array mapping of chromosome 20p deletions: genotypes, phenotypes, and copy number variation. Hum Mutat. 2009 Mar;30(3):371-8. Cited in PubMed; PMID 19058200.
Wang K, Zhang H, Kugathasan S, Annese V, Bradfield JP, Russell RK, et al. Diverse genome-wide association studies associate the IL12/IL23 pathway with Crohn Disease. Am J Hum Genet. 2009 Mar;84(3):399-405. Epub 2009 Feb 26. Cited in PubMed; PMID 19249008.
Imielinski M, Baldassano RN, Griffiths A, Russell RK, Annese V, Dubinsky M, et al. Common variants at five new loci associated with early-onset inflammatory bowel disease. Nat Genet. 2009 Dec;41(12):1335-40. Epub 2009 Nov 15. Cited in PubMed; PMID 19915574.
Colletti RB, Baldassano RN, Milov DE, Margolis PA, Bousvaros A, Crandall WV. Variation in care in pediatric Crohn disease. J Pediatr Gastroenterol Nutr. 2009 Sep;49(3):297-303. Cited in PubMed; PMID 19590456.
Abstracts (includes Posters and Scientific Presentations)
2023
Rodriguez K, Holbein C, Fussner L, Baber K, Wilkes C, Szabo M, Piccoli D, Turner E: Enhancing biopsychosocial care in pediatric gastroenterology: 10-year growth of an integrated GI Psychology program. North American Society for Pediatric Gastroenterology, Hepatology and Nutrition Annual Meeting, San Diego, CA October 2023.
2022
Hansen BE, Vandriel SM, Vig P, Garner W, Loomes KM Piccoli DA Rand EB Jankowska I, Czubkowski P, Gliwicz-MiedziÅ„ska D, Gonzales EM, Jacquemin E, Bouligand J, D'Antiga L, Nicastro E, Arnell H, Fischler B, Sokal E, Demaret T, Siew S, Stormon M, Karpen S, Romero R, Ebel NH, Feinstein JA, Roberts AJ, Evans HM, Sundaram SS, Chaidez A, Hardikar W, Shankar S, Fischer RT, Lacaille F, Debray D, Lin HC, Jensen MK, Jaramillo C, Karthikeyan P, Davison S, Indolfi G, Verkade HJ, Larson-Nath C, Quiros-Tejeira R, Valentino PL, Maria Rogalidou, Antal DezsÅ‘fi, James E. Squires, Kathleen Schwarz, Pier Luigi Calvo, Jesus Quintero Bernabeu, Andréanne N. Zizzo, Gabriella Nebbia, Pinar Bulut, Ermelinda Santos-Silva, Rima Fawaz, Silvia Nastasio, Wikrom Karnsakul, María Legarda Tamara, Cristina Molera Busoms, Deirdre Kelly, Thomas Damgaard Sandahl, Carolina Jimenez-Rivera, Jesus M. Banales, Quais Mujawar, Li-Ting Li, Huiyu She, Jian-She Wang, Kyung Mo Kim, Woo Yim Baek, Maria Camila Sanchez, Maria Lorena Cavalieri, Way Seah Lee, Christina Hajinicolaou, Chatmanee Lertudomphonwanit, Orith Waisbourd-Zinman, Cigdem Arikan, Seema Alam, Elisa Carvalho, Melina Melere, John Eshun, Zerrin Önal, Dev M. Desai, Sabina Wiecek, Raquel Borges Pinto, Victorien M. Wolters, Jennifer Garcia, Marisa Beretta, Nanda Kerkar, Jernej Brecelj, Nathalie Rock, Eberhard Lurz, Niviann Blondet, Uzma Shah, Richard J. Thompson, Binita M. Kamath and The Global ALagille Alliance (GALA) Study Group. : Maralixibat-treated patients with Alagille syndrome demonstrate improved event-free survival in a natural history comparison with patients from the GALA database: application of real-world evidence analytics. Pediatric Gastroenterology and Nutrition 74(S2), June 2022 Notes: DOI: 10.1097/MPG.0000000000003446.
BE Hansen,, SM Vandriel P Vig W Garner L-T Li H She J-S Wang MA Gilbert I Jankowska P Czubkowski D Gliwicz-MiedziÅ„ska EM Gonzales E Jacquemin J Bouligand NB Spinner KM Loomes, DA Piccoli, L D'Antiga, E Nicastro, É Sokal, T Demaret NH Ebel, JA Feinstein, R Fawaz, S Nastasio, F Lacaille, D Debray, H Arnell, B Fischler, S Siew, M Stormon, SJ Karpen, R Romero, KM Kim, WY Baek, W Hardikar, S Shankar, AJ Roberts, HM Evans, MK Jensen, M Kavan, SS Sundaram A Chaidez, P Karthikeyan, S Davison, MC Sanchez, ML Cavalieri, HJ Verkade, WS Lee, JE Squires, C Hajinicolaou, C Lertudomphonwanit, RT Fischer, C Larson-Nath, Y Mozer-Glassberg, C Arikan, HC Lin, J Quintero Bernabeu, S Alam, D Kelly, E Carvalho, C Targa Ferreira, G Indolfi, RE Quiros-Tejeira, P Bulut, PL Calvo, Z Önal PL Valentino, DM Desai, J Eshun, M Rogalidou, A DezsÅ‘fi, S Wiecek, G Nebbia RB Pinto, VM Wolters, M Legarda Tamara, AN Zizzo, J Garcia, K Schwarz, M Beretta, TD Sandahl, C Jimenez-Rivera, N Kerkar, J Brecelj, Q Mujawar, N Rock, CM Busoms, W Karnsakul, E Lurz, E Santos-Silva, N Blondet, L Bujanda, U Shah, RJ Thompson, BM Kamath The Global ALagille Alliance (GALA) Study Group. : Maralixibat-treated patients with Alagille syndrome (ALGS) demonstrate improved event-free survival in a natural history comparison with patients from the GALA database: application of real-world evidence analytics. Journal of Pediatric Gastroenterology and Nutrition. 2022.
2021
Kapavarapu PK, Javed S, Reynolds JC, Toto EL, Fiorino K, Mousa H, Piccoli DA, Ahuja NK: Development and Implementation of a Novel Hybrid Model for Neurogastroenterology and Motility Fellowship. American Neurogastroenterology and Motility Society Annual Meeting, Boston, MA August 2021.
Lectures by Invitation
2023
Piccoli DA. "Adult considerations in ALGS," ALGSA 11th International Symposium on Alagille Syndrome Presented by Ipsen and Mirum Pharmaceuticals. Jul 2023.
Piccoli DA. "Workshop Fellows' Case Presentations," Open Medical Institute, Alianza Medica Para La Salud, Mexico City, Mexico. Jun 2023.
Piccoli DA. "Neonatal Cholestasis," Open Medical Institute, Alianza Medica Para La Salud, Mexico City, Mexico. Jun 2023.
Piccoli DA. "Viral Hepatitis," Open Medical Institute, Alianza Medica Para La Salud, Mexico City, Mexico. Jun 2023.
2022
Piccoli DA. "25 Years after JAG1 - New Frontiers in ALGS Research," 10th International Symposium & Scientific Meeting on Alagille Syndrome, Cincinnati, OH. Jun 2022.
Piccoli DA. "Autoimmune Liver Diseases," American Austrian Foundation Conference, Saltzburg, Austria. Apr 2022.
Piccoli DA. "Principles of Metabolic and Genetic Liver Disease," American Austrian Foundation Conference, Saltzburg, Austria. Apr 2022.
Piccoli DA. "Liver Failure Etiology, Pathophysiology and Therapy," American Austrian Foundation Conference, Saltzburg, Austria. Apr 2022.
Piccoli DA."Liver Disease in Neonates and Infants," American Austrian Foundation Conference, Saltzburg, Austria. Apr 2022.
Piccoli DA. The American Austrian Foundation, Salzburg Medical Seminars International, Salzburg, Austria. Apr 2022.
2021
Piccoli DA. "ALGS 101," 9th International Symposium on Alagille Syndrome Virtual. Jul 2021.
Piccoli DA. "ALGS 101," 9th International Symposium on Alagille Syndrome Virtual. Jul 2021.
Piccoli DA. "ALGS and the Liver," 9th International Symposium on Alagille Syndrome Virtual. Jul 2021.
Piccoli DA. "ALGS Adults,"9th International Symposium on Alagille Syndrome Virtual. Jul 2021.
Piccoli DA. "Keynote Address," 9th International Symposium on Alagille Syndrome Virtual. Jul 2021.
Books
2023
Piccoli DA: Foreword. Pediatric Inflammatory Bowel Disease, Fourth Edition. Mamula P, Kelsen JR, Grossman AB, Baldassano RN, Markowitz JE (eds.). Springer, Page: 7-9, 2023.
2014
Russo P, Ruchelli ED, Piccoli DA: Pathology of Pediatric Gastrointestinal and Liver Disease. Springer 2014.
2014
Russo P, Ruchelli ED, Piccoli DA: Pathology of Pediatric Gastrointestinal and Liver Disease. Springer 2014.
2008
Kamath BM, Piccoli DA: Alagille Syndrome. Pediatric Gastroenterology, The Requisites. Liacouras CA, Piccoli DA (eds.). Saunders/Churchill/Mosby, Philadelphia, Page: 227-232, 2008.
Liacouras CA, Piccoli DA. Pediatric gastroenterology and nutrition: the requisites. Philadelphia: Saunders/Churchill/Mosby; 2008.
2004
Russo P, Ruchelli E, Piccoli DA, editors. Pathology of pediatric gastrointestinal and liver disease. New York: Springer-Verlag; 2004.
Editorials, Reviews, Chapters
2020
Brownell JN, Piccoli DA: Protein-Losing Enteropathy. Pediatric Gastrointestinal and Liver Disease, 6th Edition. Wyllie R, Hyams J, Kay M (eds.). Elsevier, October 2020.
Piccoli DA: Foreward. Pediatric Inflammatory Bowel Disease, Fourth Edition. Mamula P, Grossman AB, Baldassano RN, Kelsen JR, Markowitz JE (eds.). Springer, 2020.
2015
Lin HC, Piccoli DA: Ascites. Pediatric Gastrointestinal and Liver Disease, Chapter 17. Wyllie R, Hyams JS, Kay M (eds.). 2015.
2014
Kamath BM, Piccoli DA: Alagille Syndrome. Diseases of the Liver in Children. Murray KF, Horslen S (eds.). Springer, 2014.
2010
Kamath BM, Loomes KM, Piccoli DA: JAGGED1/NOTCH2 Sequence in Alagille Syndrome. Fibrocystic Disease of the Liver. Murray K (eds.). Humana Press, 2010.
2008
Kamath BM, Piccoli DA. Alagille syndrome. In: Liacouras CA, Piccoli DA, editors. Pediatric gastroenterology: the requisites. Philadelphia: Saunders/Churchill/Mosby; 2008. p. 227-232.
2007
Kamath BM, Spinner NB, Piccoli DA. Alagille syndrome. In: Suchy F, Balistreri W, Sokol RJ, editors. Liver disease in children. 3rd ed. New York: Cambridge University Press; 2007. p. 326-345.
2005
Graham-Maar RC, Piccoli DA. Gastroenterology (10), esophagus and stomach. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 102-109.
Graham-Maar RC, Piccoli DA. Esophagus and stomach. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 100-102.
Graham-Maar RC, Piccoli DA. Hepatobiliary system. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005. p. 102-109.
Graham-Maar RC, Piccoli DA. Small and large intestine. In: Frank G, Shah SS, Catallozzi M, Zaoutis LB, editors. The Philadelphia guide: inpatient pediatrics. Philadelphia: Lippincott Williams & Wilkins; 2005.
2004
Piccoli DA. Disorders of the biliary tract: intrahepatic bile ducts. In: Walker WA, Kleinman RE, Sherman PM, Schneider BL, Sanderson IR, editors. Pediatric gastrointestinal disease. Shelton: PMPH USA; 2004.
2003
Kamath BM, Piccoli DA. Alagille syndrome. In: Grand RI, editor. Encyclopedia of pediatric gastroenterology. Philadelphia: Elsevier; 2003.
2001
Piccoli DA. Alagille syndrome. In: Suchy F, editor. Liver disease in children. 2nd ed. Philadelphia: WB Saunders; 2001. p. 327-342.
2000
Piccoli DA. Disorders of the biliary tract: extrahepatic bile ducts. In: Walker WA, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: BC Decker, Inc.; 2000. p. 915-927.
Piccoli DA. Disorders of the biliary tract: intrahepatic bile ducts. In: Walker WA, editors. Pediatric gastrointestinal disease: pathophysiology, diagnosis, management. 3rd ed. Philadelphia: BC Decker, Inc.; 2000. p. 915-927.
Mamula P, Markowitz, Baldassano RN, Piccoli DA, Liacouras CA. Gastroenterology. In: Polin R, editor. Pediatric secrets. 3rd ed. Philadelphia: Hanley & Belfus, Inc.; 2000.
1999
Wenner WJ, Piccoli DA. Viral hepatitis. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 445-450.
Piccoli DA, Peck SN. Inflammatory bowel disease in children and adolescents. In: Stein SH, Rood RP, editors. Inflammatory bowel disease: a guide for patients and their families. Philadelphia: Lippincott-Raven; 1998. p. 79-92.
Piccoli DA. Hepatic fibrosis. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 391-396.
Piccoli DA. Hirschsprung disease. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 1399-1403.
Piccoli DA. Breath testing. In: Altschuler SM, Liacouras CA, editors. Clinical pediatric gastroenterology. London: Churchill Livingstone; 1998. p. 567-574.
Gibson J, Piccoli DA, Berry G. Pathophysiology of metabolic disease of the liver. In: Polin R, Fox W, editors. Fetal and neonatal physiology. 2nd ed. Philadelphia: WB Saunders; 1998. p. 1514-20.
1997
Piccoli DA. Rectal bleeding. In: Schwartz MW, Curry TA, Sargent AJ, Blum NJ, Fein J, editors. Pediatric primary care: a problem-oriented approach. 3rd ed. Philadelphia: Mosby-Year Book, Inc.; 1997. p. 346-354.