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Children’s Hospital of Philadelphia and Sidra Medicine to Establish First-Ever Pediatric Bone Marrow Transplant Program in Qatar
CHOP announced it has entered into a Memorandum of Understanding (MOU) with Sidra Medicine, a specialty healthcare organization for women, children and young people in Qatar.
Multidisciplinary Task Force Develops Clinical Recommendations for Rare, Life-Threatening Hyperinflammatory Syndromes
Hemophagocytic lymphohistiocytosis (HLH) and macrophage activation syndrome (MAS) are overlapping hyperinflammatory syndromes that involve disorganization and malfunction of the immune system, leading to widespread inflammation and organ damage. The conditions can progress rapidly, making early identification and management key for preventing organ failure and death.
CHOP-led Study Identifies Two Different Regulatory T Cell Populations
A CHOP-led study has shown that a regulatory class of T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity.
Immune Dysregulation Program: for Patients Who ‘Don’t Read the Textbook’
We all learned some simple patterns for diseases of the immune system when we were in training: immunodeficiency is “too little immune system,” autoimmunity is “too much immune system,” atopy is a “allergic immune system,” and lymphoproliferation is “a rapidly expanding immune system.”
First Approved CAR T-Cell Therapy Shows Continued Benefits Five Years Later
New data on show CAR T-cell therapy leads to durable remission and long-term survival in children and young adults with relapsed or refractory B-ALL.
MIS-C Patients Have Deeply Dysregulated Protein Profiles, According to New CHOP Research
CHOP researchers found that levels of proteins in the plasma of patients with MIS-C are significantly dysregulated and share features with two other inflammatory syndromes.
CHOP Study Finds Safest Treatment for Immunodeficiency Disorder is Not Cost Effective for U.S. Patients
Using a model developed at CHOP, researchers find high cost of treatment most likely to prevent premature death in patients with agammaglobulinemia undermines its benefits.
When Innovation Meets Necessity: CHOP Researchers’ Critical Contributions to the Battle Against COVID-19
Since March 2020, CHOP researchers have played a vital role in combatting the COVID-19 pandemic. Read highlights of their game-changing work.
CHOP Researchers Discover New Disease that Prevents Formation of Antibodies
CHOP researchers discovered a new condition, which they named PU.MA, and treated a patient with a bone marrow donation from the patient’s older brother.
Deep Immune Profiling Shows Significant Immune Activation in Children with MIS-C
Using deep immune profiling, CHOP researchers have found children with MIS-C are extremely immune activated, more like adults with severe COVID-19.