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Children’s Hospital of Philadelphia Researchers Discover that Acute Myeloid Leukemia Can Permanently Reprogram Stem Cells Through Inflammation
New research from Children’s Hospital of Philadelphia (CHOP) uncovered a previously unknown side effect of Acute Myeloid leukemia (AML), the second most common blood cancer in children, that leaves a long-lasting imprint on healthy blood-forming stem cells, influencing immune responses long after the disease has entered remission. The results were published recently in the journal Cancer Letters.
Children’s Hospital of Philadelphia Preclinical Study Unveils Promising New Treatment Approach for Fanconi Anemia Patients
In a preclinical study, researchers at Children’s Hospital of Philadelphia (CHOP) demonstrated a novel treatment strategy for patients with Fanconi anemia (FA), a rare genetic disease resulting in loss of blood-forming stem cells in the bone marrow. The researchers successfully used in situ mRNA delivered directly into the body by lipid nanoparticles (LNPs) to target bone marrow cells and transiently restore stem cell function in patients with FA.
Recognizing Poison Ivy, Oak and Sumac
The old saying goes: "Leaves of three, let them be." Poison ivy, oak and sumac are three plants that carry the same poison — urushiol, a colorless, odorless oil that causes an itchy, irritating rash in almost everyone who comes in contact with it.
Dr. Fred Henretig Received the 2024 American Academy of Pediatrics Section on Emergency Medicine’s Steve Miller Award for Excellence in Education and Mentorship
We are proud to announce that Fred Henretig, M.D., a pediatric emergency medicine physician and toxicology expert received the 2024 American Academy of Pediatrics Section on Emergency Medicine’s Steve Miller Award for Excellence in Education and Mentorship at the American Association of Pediatrics (AAP) annual meeting.
Overcoming Fears and Empowering Other Kids
Inspired by her own journey, a CHOP patient helps other children deal with the stress of managing an illness.
Air Quality FAQs for Patients & Families
You might be feeling anxious about the poor air quality in our region. While this problem is real, it does not mean that there is nothing we can do to help keep our family safe.
Researchers Determine Underlying Mechanisms of Inherited Disorder that Causes Bone Marrow Failure
Study also found that a readily available bile salt could be used as a treatment to restore proper function.
CHOP Researchers Improve Fitness of Cells Used in Cell Transplants
CHOP researchers find exposing cells to a small molecule drug improves cell fitness during hematopoietic stem cell transplants, which could improve ex vivo gene therapy.
CHOP's Jeanette Trella, PharmD, BCPPS Named a Bloomberg Fellow
We are proud to announce that Jeanette Trella, PharmD, BCPPS, Senior Director of the Center for Public Health Readiness and Response at Children’s Hospital of Philadelphia has been named a Bloomberg Fellow, a unique program and diverse network of change agents.
CHOP Researchers Find Rate of Fatal Opioid Poisonings Among Children More Than Doubled Over 13-Year Span
Over-the-counter drugs also continue to pose fatal risks to young children despite measures to reduce exposure.