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Researchers at Children’s Hospital of Philadelphia Show Gene Therapy Can Improve Quality of Life for Companion Dogs with Hemophilia
In a study published in the journal Molecular Therapy Methods and Clinical Development, researchers at Children’s Hospital of Philadelphia (CHOP), in collaboration with researchers at the School of Veterinary Medicine at the University of Pennsylvania, found that adeno-associated viral (AAV) gene therapy has the potential to be a life-changing treatment for companion dogs –pets – with severe hemophilia, an inherited bleeding disorder caused by deficiency of clotting factor.
CHOP Researchers Validate Pediatric “Allergic March” in Large National Study
In the largest study of its kind, CHOP researchers have validated a population-level pattern of pediatric allergy development known as the “allergic march.”
Promising Use for Antibody Treatment for EoE
Two recent studies show dupilumab improves eosinophilic esophagitis symptoms and pathology for adolescents and young adults.
Getting Unstuck
Personalized therapeutic approaches for children with eosinophilic esophagitis are gaining ground at CHOP.
Mini Guts
Bench-to-bedside research supports GI innovation at CHOP.
CHOP-led Study Shows Novel Gene Therapy for Hemophilia A Leads to Sustained Expression of Clotting Factor and Reduced Bleeding Events
Results from multicenter study are first to show improved production of coagulation factor VIII over prolonged period, leading to reduction or complete elimination of bleeding events.
Using FLIP to Study Motility Disorders in Children
CHOP researchers discover using FLIP in pediatric patients with achalasia significantly improves esophagogastric junction dysfunction and improves quality of life.
CHOP Gene Therapy Experts Profiled in Philadelphia Magazine
CHOP researchers were interviewed as a part of a comprehensive article about cell and gene therapy in Philadelphia Magazine.
Eosinophilic Esophagitis (EoE) Education Day 2021 Recap
During our annual EoE Education Day, patients and families participated in an exciting day featuring research updates, expert panels, interactive sessions and much more.
CHOP Researchers Pinpoint a Simple Test for Foods that Cause EoE
CHOP researchers found a simple assay using a blood sample could identify EoE milk allergy with accuracy and sensitivity.