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Children’s Hospital of Philadelphia Researchers Find Precision Medicine Treatment Delivers Strong Results for Infantile Fibrosarcoma and Other Solid Tumors
Researchers at Children’s Hospital of Philadelphia (CHOP) and the Children’s Oncology Group (COG) found that larotrectinib, an oral drug that stops cancer-cell growth, was highly effective in pediatric patients with newly diagnosed infantile fibrosarcoma (IFS) or other solid tumors that have a neurotrophic receptor tyrosine kinase (NTRK) gene fusion without a known acquired resistance mutation. The study, published today in the Journal of Clinical Oncology, is the first COG trial to test precision medicine in a front-line setting across all different types of solid tumors based on a genetic biomarker rather than histology. It is poised to redefine the approach to treatment for newly diagnosed fibrosarcoma and other solid tumors with the NTRK gene fusion, potentially reducing or eliminating the need for these patients to receive chemotherapy.
Children’s Hospital of Philadelphia Receives Multi-Million Dollar Gift from Holveck Family to Support Groundbreaking Osteosarcoma Research
Children’s Hospital of Philadelphia (CHOP) has received a $6.4 million gift from the family of Connor Boyle, a Central Bucks East High School graduate who died at age 18 from osteosarcoma. This three-year gift, named The Connor Initiative: Precision Therapeutics for Osteosarcoma & Rare Cancers, will support cutting-edge research in osteosarcoma and other rare cancers.
CHOP Researchers Validate Pediatric “Allergic March” in Large National Study
In the largest study of its kind, CHOP researchers have validated a population-level pattern of pediatric allergy development known as the “allergic march.”
Promising Use for Antibody Treatment for EoE
Two recent studies show dupilumab improves eosinophilic esophagitis symptoms and pathology for adolescents and young adults.
Integrating Precision Medicine into Standard of Care for Children with Thyroid Cancer
Read this case study about integrating precision medicine into the standard of care for children with thyroid cancer.
Getting Unstuck
Personalized therapeutic approaches for children with eosinophilic esophagitis are gaining ground at CHOP.
Mini Guts
Bench-to-bedside research supports GI innovation at CHOP.
Using FLIP to Study Motility Disorders in Children
CHOP researchers discover using FLIP in pediatric patients with achalasia significantly improves esophagogastric junction dysfunction and improves quality of life.
Eosinophilic Esophagitis (EoE) Education Day 2021 Recap
During our annual EoE Education Day, patients and families participated in an exciting day featuring research updates, expert panels, interactive sessions and much more.
CHOP Researchers Pinpoint a Simple Test for Foods that Cause EoE
CHOP researchers found a simple assay using a blood sample could identify EoE milk allergy with accuracy and sensitivity.