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Children’s Hospital of Philadelphia Researchers Discover that Acute Myeloid Leukemia Can Permanently Reprogram Stem Cells Through Inflammation
New research from Children’s Hospital of Philadelphia (CHOP) uncovered a previously unknown side effect of Acute Myeloid leukemia (AML), the second most common blood cancer in children, that leaves a long-lasting imprint on healthy blood-forming stem cells, influencing immune responses long after the disease has entered remission. The results were published recently in the journal Cancer Letters.
Children’s Hospital of Philadelphia Preclinical Study Unveils Promising New Treatment Approach for Fanconi Anemia Patients
In a preclinical study, researchers at Children’s Hospital of Philadelphia (CHOP) demonstrated a novel treatment strategy for patients with Fanconi anemia (FA), a rare genetic disease resulting in loss of blood-forming stem cells in the bone marrow. The researchers successfully used in situ mRNA delivered directly into the body by lipid nanoparticles (LNPs) to target bone marrow cells and transiently restore stem cell function in patients with FA.
Overcoming Fears and Empowering Other Kids
Inspired by her own journey, a CHOP patient helps other children deal with the stress of managing an illness.
Researchers Determine Underlying Mechanisms of Inherited Disorder that Causes Bone Marrow Failure
Study also found that a readily available bile salt could be used as a treatment to restore proper function.
CHOP Researchers Improve Fitness of Cells Used in Cell Transplants
CHOP researchers find exposing cells to a small molecule drug improves cell fitness during hematopoietic stem cell transplants, which could improve ex vivo gene therapy.
CHOP Researchers Validate Pediatric “Allergic March” in Large National Study
In the largest study of its kind, CHOP researchers have validated a population-level pattern of pediatric allergy development known as the “allergic march.”
Promising Use for Antibody Treatment for EoE
Two recent studies show dupilumab improves eosinophilic esophagitis symptoms and pathology for adolescents and young adults.
Getting Unstuck
Personalized therapeutic approaches for children with eosinophilic esophagitis are gaining ground at CHOP.
Mini Guts
Bench-to-bedside research supports GI innovation at CHOP.
Using FLIP to Study Motility Disorders in Children
CHOP researchers discover using FLIP in pediatric patients with achalasia significantly improves esophagogastric junction dysfunction and improves quality of life.