Research News from CHOP
New Research Sheds Light on Long-Term Pulmonary Outcomes for Bronchopulmonary Dysplasia Patients
Researchers revealed new insights into the long-term effects of bronchopulmonary dysplasia (BPD), a chronic lung disease that primarily affects premature infants, on patient health.
CHOP Researchers Develop New Strategy for Assessing Natural History of Leukodystrophies
The methodology developed in this study could help guide clinical trial design for many rare diseases
Researchers Find No Link Between COVID-19 Virus and Development of Asthma in Children
The large study also confirmed known risk factors for COVID-19 associated with asthma in children.
CHOP, Stanford Researchers Identify Protein That Controls CAR T Cell Longevity
FOXO1 is required for memory in T cells and is associated with more durable clinical responses to CAR T cell therapy.
Youths with Mood Disorders 30 Percent Less Likely to Acquire Driver’s License Than Peers
First large-scale study on licensure and driving outcomes among teens and young adults with mood disorders also finds overall crash rates slightly higher for those newly licensed.
CHOP Researchers Develop Method for Integrating Patient-Reported Outcomes for Patients with Primary Mitochondrial Disease
The findings also found that older patients with primary mitochondrial disease have a lower quality of life than pediatric patients with the same disease.
Researchers Determine Underlying Mechanisms of Inherited Disorder that Causes Bone Marrow Failure
Study also found that a readily available bile salt could be used as a treatment to restore proper function.
CHOP Researchers Find Branched Chain Amino Acid Supplementation May Aid in Concussion Recovery
Pilot study reveals early evidence of efficacy of a pharmacologic treatment for concussion, as patients experienced faster symptom reduction and return to physical activity
CHOP Researchers Discover Key Metabolic Process Responsible for Rapid Immune Responses
A metabolite called NAD encourages immune cells to divide more quickly and could be used to improve efficacy of cell-based therapies.
CHOP Researchers Find Pre-Existing Mental Health Diagnoses May Prolong Time to Recovery from Concussion
Pre-existing mental health diagnoses associated with longer recovery times and greater emotional burden after concussion, affecting boys with prolonged recovery at a higher rate than girls.