Research News from CHOP

CHOP Cancer Researchers Win 2021 AACR Team Science Award
The award was presented to the St. Baldrick’s Foundation-Stand Up 2 Cancer Pediatric Cancer Dream Team, co-led by CHOP, at the annual AACR conference.
Children’s Hospital of Philadelphia’s Dr. N. Scott Adzick Receives Clinical and Translational Science Distinguished Investigator Award for Bringing Fetal Surgery from the Lab to the Clinic
Award recognizes a researcher who has translated a proof-of-concept study to widespread clinical practice.
The EVAN Foundation Pledges to Continue its Support of the Evan Lindberg Neuroblastoma Research Scholars Program at CHOP
Established in 2015, the Evan Lindberg Neuroblastoma Research Scholars Program supports exceptional early-career scientists at CHOP who are dedicated to finding a cure for neuroblastoma.
CHOP Researchers Find Supplement Prevents Strokes in Patients with Rare Genetic Disorder
Supplement proved effective at preventing the formation of amyloid proteins, which may lead to treatments for certain forms of dementia.
Researchers Identify Head Impact Rates in Four Major High School Sports
Large study provides head impact sensor analysis across four sports and both genders, a first for basketball and field hockey.
CHOP Researchers Awarded Crazy 8 Grant from Alex’s Lemonade Stand Foundation
CHOP researchers will receive funds to discover a new drug that targets MYCN, a transcription factor involved in some pediatric cancers.
CHOP Researchers Find Ribosome Assembly Essential for Stem Cell Regeneration
The findings identify possible targets for future therapies for ribosomopathies, childhood disorders that lead to bone marrow failure (BMF).
Researchers Identify RNA Editing Events that Impact Gene Expression and Phenotype
CHOP researchers have identified RNA editing events that influence gene expression and phenotype, showing that a single nucleotide change can have large downstream effects.
Using Digital Health Tools to Screen Children for Suicide Risk
CHOP expert leading the effort to develop a chatbot to screen children for suicide risk in a more efficient and scalable manner.

Deep Immune Profiling Shows Significant Immune Activation in Children with MIS-C
Using deep immune profiling, CHOP researchers have found children with MIS-C are extremely immune activated, more like adults with severe COVID-19.