Research News from CHOP

CHOP Researchers Develop a New Class of CAR-T Cells that Target Previously Untargetable Cancer Drivers
CHOP researchers have developed a novel cancer therapy that targets proteins inside cancer cells that are essential for tumor growth and survival but have been historically impossible to reach.
Study Rewrites Dogma of Adenovirus Infection and Double-stranded RNA
CHOP researchers have found no detectable levels of double-stranded RNA during adenovirus infection, upending previous assumptions about infection by the virus.

CHOP-led Study Finds Healthy Newborns Had Shorter Hospital Stays During COVID-19 Pandemic with No Change in Readmissions
Study by CHOP researchers suggests shorter hospital stays for healthy term infants might be safe outside of a pandemic scenario, with implications for health care costs and best practices.
CHOP Researchers Find Golf Carts Injure More than 6,500 Children Annually
CHOP researchers have found that the number of golf cart-related injuries have risen steadily over the past decade, as the use of golf carts has increased.
CHOP-led Study Finds that Biggest Share of U.S. Obstetric Hospitals Deliver Fewer than 500 Babies Per Year
CHOP researchers found that a plurality of hospitals delivers fewer than 500 infants per year and that nearly a fifth of low-volume hospitals are more than 30 miles from another obstetric hospital.
CHOP Researchers Find That Differences in Mitochondria Lead to More Severe Cases of Rare Genetic Disease
Mitochondria are not "properly recycled" in some cases, and this may serve as a potential target for future therapeutic interventions.
Researchers Find Dramatic Drop in Vaccinations During Early Pandemic
In a CHOP-led study, researchers found a dramatic drop across the lifespan during the early pandemic, as well as a decrease in sites providing pediatric vaccinations.
Researchers From CHOP, Penn Receive $5.3 Million Grant to Reduce Unnecessary Hospital Monitoring Practices
The goal of this “deimplementation” study is to reduce risk while aligning practice with the best available evidence.

Researchers at CHOP Join Forces to Study Connections Between Mitochondria and Cancer
The Mitochondria and Cancer Connections (MC²) Research Program will study how cancer cells find the energy to grow and ways to prevent their return.
In Celebration of the Abraham Accords, CHOP Hosts Pediatric Experts from the United Arab Emirates (U.A.E.) and Israel to Share Knowledge, Research
A year after the signing of the Abraham Accords — a declaration recognizing the importance of strengthening peace around the world — leaders and clinicians from CHOP hosted a meeting to share knowledge and research with pediatric experts from CHOP, the U.A.E. and Israel.