Research News from CHOP
CHOP Researchers Find Bystander CPR with Rescue Breathing Leads to Better Outcomes in Pediatric Cardiac Arrest
CHOP researchers have found that CPR with rescue breathing leads to better neurological outcomes in pediatric cardiac arrest, highlighting a need for education.
When Innovation Meets Necessity: CHOP Researchers’ Critical Contributions to the Battle Against COVID-19
Since March 2020, CHOP researchers have played a vital role in combatting the COVID-19 pandemic. Read highlights of their game-changing work.
CHOP Study Finds Children with Fontan Circulation Have Slightly Shorter Stature
CHOP researchers found that children with Fontan circulation are slightly shorter than their peers, but further studies are needed to determine whether this effect is long-lasting.
CHOP Researchers: Pandemic Worsening a Global Youth Mental Health Crisis
CHOP researchers authored an editorial in JAMA Pediatrics on the effects of the COVID-19 pandemic on youth mental health.
Positive Preliminary Data on CRISPR Treatment for Blood Diseases
A collaborative team of researchers, including Dr. Stephan Grupp, recently presented preliminary data showing that a CRISPR-based gene-editing therapy for inherited blood disorders is safe and effective.
Passing the Sniff Test: CHOP Researchers Identify SARS-CoV-2 Breath Biomarkers in Children
CHOP researchers have identified six biomarkers in the breath of children with COVID-19, laying the groundwork for a potential breathalyzer test.
CHOP Researchers Develop Coating for Endotracheal Tubes that Releases Antimicrobial Peptides
CHOP researchers have developed a coating for endotracheal tubes that prevents the growth of harmful bacteria that cause inflammation and other complications.
Children’s Hospital of Philadelphia Researchers Identify Approach for Potential Nontypeable Haemophilus Influenzae Vaccine
CHOP researchers have identified two proteins that could be used for a potential vaccine against nontypeable Haemophilus influenzae, a bacterium that can lead to death in children and adults.
Youth-Onset Type 2 Diabetes Leads to Serious Complications by Early Adulthood
The landmark TODAY2 study found that those diagnosed with type 2 diabetes during childhood and adolescence have a high risk of developing serious health complications by early adulthood.
Children’s Hospital of Philadelphia Researchers Develop “Dimmer Switch” to Help Control Gene Therapy
CHOP researchers have developed a “dimmer switch” system based on alternative RNA splicing that can control levels of proteins expressed from gene therapy vectors.