Research News from CHOP
CHOP Researchers Uncover Molecular Basis of Antigen Processing for Cancer Target MR1
CHOP researchers have revealed the molecular mechanics of a cell-surface molecule that is a potential immunotherapy target.
Autism Screening Disparities Persisted During First Year of COVID-19 Pandemic
Despite maintaining relatively high overall screening rates, canceled well-child visits and incomplete screenings may impact early intervention.
CHOP Researchers Assess Effectiveness of Telemedicine for Pediatric Patients with Genetic Conditions
While diagnostic rates were similar, challenges related to sample collection and overcoming barriers to care persist.
CHOP Researchers Develop Allogeneic CART for Relapsed or Refractory T-ALL Using Base Editing
CHOP researchers have tested and developed an “off-the-shelf” chimeric antigen receptor T-cell (CART) using base editing.
CHOP Study Aims to Reveal How Genetics, Environment Contribute to Psychiatric and Cognitive Outcomes
CHOP researchers have integrated environmental, genetic, and imaging data to better understand which factors might be clinically relevant when it comes to psychiatric and cognitive outcomes.
In New Age of Telemedicine, CHOP Researchers Identify Child Neurology Patients Who Still Require In-Person Visits
While telemedicine appeared to be effective in 95% of cases, some younger patients and those with neuromuscular disorders still required in-person visits.
Children’s Hospital of Philadelphia Awards Gold Medal to Dr. Katherine High, Gene Therapy Pioneer
Prestigious award recognizes Dr. High’s contribution to improving children’s health through her gene therapy research, which began during her time at CHOP.
CHOP Researchers Develop New Computational Tool to Interpret Clinical Significance of Cancer Mutations
CHOP researchers have developed new software called CancerVar, which helps researchers assess the clinical impacts of over 13 million somatic cancer mutations.
CHOP Study Finds Neighborhood Poverty and Crowding Associated with Higher Rates of COVID-19 in Pregnancy
CHOP researchers found neighborhood characteristics were associated with higher rates of SARS-CoV-2 in pregnancy during the prevaccination era of the COVID-19 pandemic.
Benefits of Exercise May Vary Greatly in Primary Mitochondrial Disease
While the benefits of exercise may outweigh the risks, genetic status should be considered when recommending it as therapy.