Research News from CHOP

CHOP Researchers Develop First-Of-Its-Kind Prediction Model for Newborn Seizures
The model could predict which newborns would receive the most benefit from monitoring with continuous EEG to detect seizures.
CHOP Researchers Find Strong Adolescent-Parent Relationships Lead to Better Long-term Health Outcomes in Young Adults
Based on thousands of adolescents who were followed over a period of more than a decade, this new work represents one of the largest studies on parent-adolescent relationships.
Oxygen Readings May Be Affected by Darker Skin Tones
Researchers found higher rates of false positives in African American children in preliminary data.
CHOP Researchers Find Rate of Fatal Opioid Poisonings Among Children More Than Doubled Over 13-Year Span
Over-the-counter drugs also continue to pose fatal risks to young children despite measures to reduce exposure.
CHOP Selected As New Center for Turning Research Results Into Clinical Practice
CHOP is one of 42 institutions selected by the Patient-Centered Outcomes Research Institute (PCORI) as part of the $50 million initiative.

FDA Approves First Drug for Friedreich’s Ataxia
The drug, omaveloxolone, is a once-a-day pill that will help improve neurological function and slow progression of the neurodegenerative disease.
CHOP Expert Breaks Down Latest Hemophilia A Gene Therapy Data
CHOP gene therapy expert Dr. Lindsey George reacts to a phase 3 hemophilia gene therapy study in an editorial in the New England Journal of Medicine.
CHOP Researchers Develop First Effective Preclinical Models for Most Common Genetic Cause of Leigh Syndrome
Translational findings in new models of SURF1 mitochondrial disease also suggest that two drugs, already FDA-approved for other conditions, may prevent neurological decompensation in Leigh syndrome patients.
CHOP Study Finds Multidisciplinary Approach Best When Assisting Families with Limited English Proficiency
Implementing a series of quality improvement measures in the emergency room increased the use of medical interpreters and led to better documentation of language needs.
CHOP Researcher Leads International Panel in Developing First-Ever Clinical Diagnosis Guidelines for MOGAD
Patients with this complex neurological disorder experience a wide variety of symptoms, which can be managed with early and proper diagnosis.