Since infants rely on antibodies passed from mother to baby during pregnancy, the findings suggest a need for alternative strategies for boosting infant immunity in the event of an outbreak.

CHOP researchers have developed a custom-built application to automate determination of engraftment, a key outcome after hematopoietic stem cell transplant.

CHOP researchers have developed a new computational tool that can more accurately discover and quantify RNA molecules from these error-prone long-read RNA sequencing data.

Researchers in CHOP’s Pediatric Heart Valve Center have found that the neurotransmitter serotonin can adversely affect the heart’s mitral valve, contributing to a heart disease known as degenerative mitral regurgitation.

This novel method uses fruit flies and zebra fish to validate the function behind a gene associated with sleep regulation and may be a target for studies on sleeping disorders.

CHOP researchers have led an international group of experts in developing new guidelines for neonatal resuscitation research.

CHOP researchers have found that before the wide availability of vaccines, newborns were infected with SARS-CoV-2 at variable rates and without apparent short-term effects.

An NIH-funded study showed those with a history of MIS-C had mild reactions to the vaccine, with no diagnosis of myocarditis or recurrent MIS-C.

This “multimodal” analysis helps reveal relationships between different aspects of a cell and how they might impact disease development.

A study involving CHOP researchers found that a weekly dose of dupilumab, a monoclonal antibody, led to a reduction of symptoms and tissue improvement in young adults and adolescents with eosinophilic esophagitis (EoE).