Using 3D imaging, researchers in the Cardiac Center at Children’s Hospital of Philadelphia (CHOP) have found that patients with hypoplastic left heart syndrome (HLHS) experiencing moderate to severe tricuspid regurgitation (TR) have structural differences in their tricuspid valve.

Findings demonstrate how a new computational method could effectively analyze phenotypes and identify similarities among patient populations.

Children’s Hospital of Philadelphia (CHOP) today announced that it has received more than $10 million in a series of gifts to fund critical neurofibromatosis research from the Gilbert Family Foundation, a private foundation established by Dan and Jennifer Gilbert to accelerate a cure for neurofibromatosis type 1 (NF1).

CHOP researchers have shown that adenovirus proteins use a process called phase separation to coordinate production of viral progeny, which could have broad implications.

A CHOP-led study has shown that a regulatory class of T cells descends from two different origins, one that relates to autoimmunity and one that relates to protective immunity.

Two research teams in CHOP’s Cardiac Center have been awarded research grants to study single ventricle congenital heart disease.

Researchers found higher rates of false positives in African American children in preliminary data.

Based on thousands of adolescents who were followed over a period of more than a decade, this new work represents one of the largest studies on parent-adolescent relationships.

The model could predict which newborns would receive the most benefit from monitoring with continuous EEG to detect seizures.

A new study involving CHOP researchers found that daily use of a “peanut patch” for one year was effective in desensitizing a majority of peanut-allergic toddlers.