Research News from CHOP

Gene Splicing Reduces Effectiveness of CD20-Targeting Monoclonal Antibodies Designed to Treat Variety of Blood Cancers and Disorders
Researchers found CAR T-cell therapy may serve as effective alternative for patients with these disorders.
Children’s Hospital of Philadelphia Receives Multi-Million Dollar Gift from Holveck Family to Support Groundbreaking Osteosarcoma Research
Children’s Hospital of Philadelphia (CHOP) has received a $6.4 million gift from the family of Connor Boyle, a Central Bucks East High School graduate who died at age 18 from osteosarcoma. This three-year gift, named The Connor Initiative: Precision Therapeutics for Osteosarcoma & Rare Cancers, will support cutting-edge research in osteosarcoma and other rare cancers.
CHOP Researchers Find Racial, Neighborhood Disparities in Pediatric Cardiac Arrest
In an abstract presented at AHA, researchers found Black children are more than four times as likely to experience cardiac arrest and have significantly worse survival outcomes.
CHOP, Penn researchers develop gene editing approaches for PKU treatment
The two studies, presented at ASHG 2023, identified base editing and prime editing approaches for treating the rare newborn genetic disease
CHOP surgeons find over-the-counter medications control pain after elbow surgery as effectively as opioids
CHOP researchers found children who take only ibuprofen or acetaminophen after routine elbow surgery report similar pain control to patients who take opioids.
CHOP Researchers Find Pediatric E-Scooter Injuries Rose More than 70% from 2020 to 2021
In research presented at the AAP annual meeting, CHOP experts found the number of injuries associated with riding e-scooters rose most among teenage boys.
Two CHOP Researchers Named 2023 STAT Wunderkinds
Two CHOP researchers were selected by the health and science news outlet STAT as 2023 Wunderkinds, an award that celebrates the next generation of scientific superstars.
Virtual Driving Assessment Predicts Risk of Crashing for Newly Licensed Teen Drivers
CHOP findings move the science closer to precision crash prevention, targeted strategies to improve student drivers’ skills.

CHOP Researchers Show “Cryptic” Viral Peptide Drives Large Part of Immune Response in Influenza A Virus Infection
A new study by researchers at CHOP and Penn has identified an important role for a non-classical MHC molecule that engages with a cryptic viral peptide derived from influenza A virus.

Two Research Leaders from CHOP Elected to National Academy of Medicine
CHOP Chief Scientific Officer Susan Furth, MD, PhD, and PEDSnet founder Christopher B. Forrest, MD, PhD have been elected to the National Academy of Medicine.