Children’s Hospital of Philadelphia (CHOP) is recruiting research participants for a new study called, “DISCOVERY of Risk Factors for Type 2 Diabetes in Youth.” The observational study, led by Lorraine L. Katz, MD, an attending physician here at CHOP, investigates the causes and onset of type 2 diabetes (T2D) in at-risk youth ages 9-14 years as they transition through puberty.
Pediatric studies have shown the need to prevent or treat youth before the onset of T2D because:
- The decline in beta-cell function is more rapid in youth with T2D than adults.
- Youth with prediabetes or T2D had more insulin resistance than adults.
- Most youth with T2D are diagnosed during or after puberty, presenting a window of opportunity for early identification of those at risk.
- Puberty entails significant hormonal changes, including a transient decline in insulin sensitivity of around 25-30%, which recovers with completion of puberty for most adolescents.
- For youth with ongoing weight gain, the decline in insulin sensitivity may not remit. This critical period of pubertal-insulin resistance may potentially enhance their risk of dysglycemia.
Understanding the early course of prediabetes and the precursors of T2D in youth is paramount to identifying interventions that can interrupt this disease process at an early stage.
Eligible adolescents will be screened and enrolled through CHOP endocrinology clinics.
Your patient may be eligible if they:
- Are between 9-14 years old
- Are in the early stages of puberty
- Have a BMI in the 85th percentile or higher
- Have an elevated HbA1c of 5.5% or higher
Children with a history of diabetes will not be eligible for this study.
DISCOVERY (RFA-DK-21-002 / RFA-DK-21-003) includes 15 clinical centers across the nation that aim to collect information from 3,600 at-risk adolescents for youth-onset T2D. The information collected will provide insight and understanding into the early pathophysiology of prediabetes and help provide vital information on precursors of prediabetes and T2D in adolescents.
To refer eligible patient families, please contact us at DISCOVERYSTUDY@chop.edu.
For more information about the DISCOVERY study visit discovery.bsc.gwu.edu.
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Children’s Hospital of Philadelphia (CHOP) is recruiting research participants for a new study called, “DISCOVERY of Risk Factors for Type 2 Diabetes in Youth.” The observational study, led by Lorraine L. Katz, MD, an attending physician here at CHOP, investigates the causes and onset of type 2 diabetes (T2D) in at-risk youth ages 9-14 years as they transition through puberty.
Pediatric studies have shown the need to prevent or treat youth before the onset of T2D because:
- The decline in beta-cell function is more rapid in youth with T2D than adults.
- Youth with prediabetes or T2D had more insulin resistance than adults.
- Most youth with T2D are diagnosed during or after puberty, presenting a window of opportunity for early identification of those at risk.
- Puberty entails significant hormonal changes, including a transient decline in insulin sensitivity of around 25-30%, which recovers with completion of puberty for most adolescents.
- For youth with ongoing weight gain, the decline in insulin sensitivity may not remit. This critical period of pubertal-insulin resistance may potentially enhance their risk of dysglycemia.
Understanding the early course of prediabetes and the precursors of T2D in youth is paramount to identifying interventions that can interrupt this disease process at an early stage.
Eligible adolescents will be screened and enrolled through CHOP endocrinology clinics.
Your patient may be eligible if they:
- Are between 9-14 years old
- Are in the early stages of puberty
- Have a BMI in the 85th percentile or higher
- Have an elevated HbA1c of 5.5% or higher
Children with a history of diabetes will not be eligible for this study.
DISCOVERY (RFA-DK-21-002 / RFA-DK-21-003) includes 15 clinical centers across the nation that aim to collect information from 3,600 at-risk adolescents for youth-onset T2D. The information collected will provide insight and understanding into the early pathophysiology of prediabetes and help provide vital information on precursors of prediabetes and T2D in adolescents.
To refer eligible patient families, please contact us at DISCOVERYSTUDY@chop.edu.
For more information about the DISCOVERY study visit discovery.bsc.gwu.edu.
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Division of Endocrinology and Diabetes