Yiming Zhong, PhD, FACMG
Locations: Main Building
About Yiming Zhong, PhD, FACMG
Titles
Laboratory Director, Division of Genomic Diagnostics
Assistant Professor of Clinical Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania
Certifications
Clinical Cytogenetics and Genomics – American Board of Medical Genetics and Genomics
Molecular Genetic Pathology – American Board of Medical Genetics and Genomics
Awards and Honors
2001, Outstanding graduate student award, Chinese Academy of Sciences
1996-1998, People's Scholarship and student merit award, Wuhan University
Leadership and Memberships
Memberships in Professional Organizations
2021-present, American College of Medical Genetics and Genomics
2017-present, Association for Molecular Pathology
2016-present, Association of Chinese Geneticists of America
Editorial and Academic Positions
Editorial Positions
2021-present, Manuscript reviewer, Archives of Pathology & Laboratory Medicine
2020-present, Manuscript reviewer, Cancer Genetics
2013-present, Manuscript reviewer, Chinese Medical Journal
Academic and Institutional Committees
2019-present, Laboratory Genetics and Genomics (LGG) Fellowship program evaluation committee
2019-present, Laboratory Genetics and Genomics (LGG) Fellowship selection committee
Education & training
Graduate Degree
PhD in Molecular, Cellular, and Developmental Biology - The Ohio State University, Columbus, OH
MS in Genetics, Institute of Genetics and Developmental Biology - Chinese Academy of Sciences, Beijing, China
Fellowship
Clinical Cytogenetics and Genomics - Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH
Clinical Molecular Genetics and Genomics - Case Western Reserve University/University Hospitals Cleveland Medical Center, Cleveland, OH
Publications
Publications
2022
Feng Xu, Erfan Aref-Eshghi, Jinhua Wu, Jeffrey Schubert, Gerald Wertheim, Tricia Bhatti, Jennifer Pogoriler, Maha Patel, Kajia Cao, Ariel Long, Zhiqian Fan, Elizabeth H Denenberg, Elizabeth A Fanning, Donna M Wilmoth, Minjie Luo, Laura K Conlin, Aleksandra S Dain, Kristin Zelley, Sarah Baldino, Naomi Balamuth, Suzanne MacFarland, Marilyn M. Li, Yiming Zhong*: A Novel TP53 Tandem Duplication in a Child with Li-Fraumeni Syndrome. Cold Spring Harbor Molecular Case Studies March 2022.
Chelsea Kotch, Michael Fisher, Yiming Zhong, Dan Gallo, Emily Fan, Fumin Lin, Jiani Chen, Mariarita Santi, and Marilyn Li: Atypical teratoid rhabdoid tumor in a child with neurofibromatosis type 2: A novel dual diagnosis. Cancer Genetics 262-263, April 2022.
Feng Xu, Angela N. Viaene, Jenny Ruiz, Jeffrey Schubert, Jinhua Wu, Jiani Chen, Kajia Cao, Weixuan Fu, Rochelle Bagatell, Zhiqian Fan, Ariel Long, Luca Pagliaroli, Yiming Zhong, Minjie Luo, Portia A. Kreiger, Lea F. Surrey, Gerald B. Wertheim, Kristina A. Cole, Marilyn M. Li, Mariarita Santi & Phillip B. Storm : Novel ATXN1/ATXN1L::NUTM2A fusions identified in aggressive infant sarcomas with gene expression and methylation patterns similar to CIC-rearranged sarcoma. Acta Neuropathologica Communications. 2022 Jul 14;10(1):102. doi: 10.1186/s40478-022-01401-z.
2021
Yiming Zhong*, Feng Xu, Jinhua Wu, Jeffrey Schubert, Marilyn M Li: Application of Next Generation Sequencing in Laboratory Medicine. Annals of Laboratory Medicine 41(1): 25-43, Jan 2021.
Erfan Aref-Eshghi, Fumin Lin, Marilyn M. Li, Yiming Zhong*: The oncogenic roles of NTRK fusions and methods of molecular diagnosis. Cancer Genetics 2021 Nov;258-259:110-119.
2020
Yiming Zhong, Jeffery Schubert, Jinhua Wu, Feng Xu, Fumin Lin, Kajia Cao, Kristin Zelley, Minjie Luo, Jessica Foster, Kristina A Cole, Suzanne Macfarland, Adam C Resnick, Phillip B Storm and Marilyn M Li: A Germline PALB2 Pathogenic Variant identified in a Pediatric High Grade Glioma. Cold Spring Harbor Molecular Case Studies doi: 10.1101/mcs.a005397, Aug 2020.
Oscar Lopez-Nunez, Barbara Cafferata, Mariarita Santi, Sarangarajan Ranganathan, Thomas M Pearce, Scott M Kulich, Kelly M Bailey, Alberto Broniscer, Sabrina Rossi, Angelica Zin, MacLean P Nasrallah, Marilyn M Li, Yiming Zhong, Evelina Miele, Rita Alaggio, Lea F Surrey. : The spectrum of rare central nervous system (CNS) tumors with EWSR1-non-ETS fusions: Experience from three pediatric institutions with review of the literature. Brain Pathology doi: 10.1111/bpa.12900. , Sep 2020.
Yiming Zhong#, Fumin Lin#, Feng Xu, Jeff Schubert, Jinhua Wu, Luanne Wainwright, Xiaonan Zhao, Kajia Cao, Zhiqian Fan, Jiani Chen, Shih-Shan Lang, Benjamin C. Kennedy, Angela N. Viaene, Mariarita Santi, Adam C. Resnick, Phillip B. Storm, Marilyn M. Li. : Genomic characterization of a PPP1CB-ALK fusion with fusion gene amplification in a congenital glioblastoma. Cancer Genetics 252-253: 37-42, Dec 2020.
Yiming Zhong*, Feng Xu, Jinhua Wu, Jeffrey Schubert, Marilyn M Li: Application of Next Generation Sequencing in Laboratory Medicine. Annals of Laboratory Medicine 41(1): 25-43, Jan 2021.
2016
Stiff A, Trikha P, Wesolowski R, Kendra K, Hsu V, Uppati S, McMichael E, Duggan M, Campbell A, Keller K, Landi I, Zhong Y, Dubovsky J, Howard JH, Yu L, Harrington B, Old M, Reiff S, Mace T, Tridandapani S, Muthusamy N, Caligiuri MA, Byrd JC, Carson WE 3rd.: Myeloid-Derived Suppressor Cells Express Bruton's Tyrosine Kinase and CanBe Depleted in Tumor-Bearing Hosts by Ibrutinib Treatment. Cancer Res. 76(8): 2125-36, Apr 2016.
2015
Zhong Y, Dong S, Strattan E, Ren L, Butchar JP, Thornton K, Mishra A, Porcu P, Bradshaw JM, Bisconte A, Owens TD, Verner E, Brameld KA, Funk JO, Hill RJ, Johnson AJ, Dubovsky JA: Targeting Interleukin-2-inducible T-cell Kinase (ITK) andResting Lymphocyte Kinase (RLK) Using a Novel Covalent Inhibitor PRN694. The Journal of Biological Chemistry 290(10): 5960-78, Mar 2015.
Ta-Ming Liu*, Jennifer A Woyach*, Yiming Zhong*, Arletta Lozanski, Gerard Lozanski, Shuai Dong, Ethan Strattan, Amy Lehman, Xiaoli Zhang, Jeffrey A Jones, Joseph Flynn,Leslie A Andritsos, Kami Maddocks, Samantha M Jaglowski, Kristie A Blum, John C Byrd, Jason A Dubovsky, Amy J Johnson.: Hypermorphic mutation of phospholipase C, gamma 2 acquired in ibrutinib resistant CLL confers BTK independency upon BCR activation. Blood. 126(1): 61-8, Jul 2015.
2014
Jennifer A. Woyach, Kelly Smucker, Lisa L. Smith, Arletta Lozanski, Yiming Zhong, Amy S. Ruppert, David Lucas, Katie Williams, Weiqiang Zhao, Laura Rassenti, Emanuela Ghia, Thomas J. Kipps, Rose Mantel, Jeffrey Jones, Joseph Flynn, Kami Maddocks, Susan O'Brien, Richard R. Furman, Danelle F. James, Fong Clow, Gerard Lozanski, Amy J. Johnson, John C. Byrd.: Prolonged Lymphocytosis During IbrutinibTherapy Is Associated With Distinct Molecular Characteristics and Does Not Indicate A Suboptimal Response To Therapy. Blood 123(12): 1810-7, Mar 2014.
Yiming Zhong, Dalia El-Gamal, Jason Dubovsky, Kyle Beckwith, Bonnie Harrington, Katie Williams, Virginia Goettl, Shruti Jha, Xiaokui Mo, Jeffrey Jones, Joseph Flynn, Kami Maddocks, Leslie Andritsos, Dilara McCauley, Sharon Shacham, Michael Kauffman, John Byrd, and Rosa Lapalombella.: Selinexor suppresses Downstream Effectors of B-cell activation, proliferation and migration in chronic lymphocytic leukemia cells. Leukemia 28(5): 1158-63, May 2014.
Yiming Zhong *, Amy J. Johnson, John C. Byrd, and Jason A. Dubovsky*: Targeting Interleukin-2-Inducible T-cell Kinase (ITK) in T-Cell Related Diseases. Journal of Postdoctoral Research 2(6): 1-11, Jun 2014.
Yiming Zhong, John C. Byrd, Jason A. Dubovsky: The B-cell Receptor Pathway: A Critical Component of Healthy and Malignant Immune Biology. Seminars in Hematology Seminars in Hematology 51(3): 206-18, Jul 2014.
Dalia El-Gamal, Katie Williams, Taylor LaFollette, Matthew Cannon, James Blachly, Yiming Zhong, Jennifer Woyach, Erich Williams, Farrukh Awan, Jeffrey Jones, Leslie Andritsos, Kami Maddocks, Chia-Hsien Wu, Ching-Shih Chen, Amy Lehman, Xiaoli Zhang, Rosa Lapalombella, and John C Byrd: PKC-β as a therapeutic target in CLL: PKC Inhibitor AEB071 Demonstrates Pre-clinical Activity in CLL. Blood 124(9): 1481-91, Aug 2014.
Jason A. Dubovsky, Ryan Flynn, Jing Du, Bonnie K. Harrington, Yiming Zhong, Carrie Yang, Will Towns, Amy Lehman, Amy J. Johnson, Natarajan Muthusamy, Steven Devine, Samantha Jaglowski, Jonathan S. Serody, William J. Murphy, David H. Munn, Leo Luznik, Geoffrey R. Hill, Kelli K.P. MacDonald, Ivan Maillard, John Koreth, Corey Cutler, Robert J. Soiffer, Joseph H. Antin, Jerome Ritz, Angela Panoskaltsis-Mortari, John C. Byrd, Bruce R. Blazar.: Ibrutinib Treatment Ameliorates Murine Chronic Graftversus-Host Disease. The Journal of Clinical Investigation 124(11): 4867-76, Nov 2014.
Shuai Dong, Daphne Guinn, Jason A Dubovsky, Yiming Zhong, Amy Lehman, Jeffery Kutok, Jennifer A Woyach, John C. Byrd, and Amy J Johnson.: IPI-145 antagonizes intrinsic and extrinsic survival signals in chronic lymphocytic leukemia cells. Blood 124(24): 3583-6, Dec 2014.
2013
Dubovsky JA, Beckwith KA, Natarajan G, Woyach JA, Jaglowski S, Zhong Y, Hessler JD, Liu TM, Chang BY, Larkin KM, Stefanovski MR, Chappell DL, Frissora FW, Smith LL, Smucker KA, Flynn JM, Jones JA, Andritsos LA, Maddocks K, Lehman AM, Furman R, Sharman J, Mishra A, Caligiuri MA, Satoskar AR, Buggy JJ, Muthusamy N, Johnson AJ, Byrd JC.: Ibrutinib is an irreversible molecular inhibitor of ITK driving a Th1-selective pressure in T lymphocytes. Blood 122(15): 2539-49, Oct 2013.
Zhong Y and Byrd JC: IRF4-/-Vh11 mice: a novel mouse model of CLL. Blood 122(16): 2769-70, 2013.
Zhong Y and Byrd JC: UGT2B17 as a disease accelerator in CLL. Blood 121(7): 1067-8, 2013.
2012
Lapalombella R, Sun Q, Williams Katie, Jha S, Zhong Y, Goettl V, Mahoney E,Berglund C, Alicia F, Rajes M, Johnson AJ; Lucas DM, Mo X, Dirk D, Vincent S, Sharon S, Dilara M, Sharon S, Michael K, Yuh MC, Byrd JC.: Selective Inhibitors of Nuclear Export (SINE) show that CRM1/XPO1 is a target in Chronic Lymphocytic Leukemia. Blood 120(23): 4621-34, Nov 2012.
2011
Motiwala T, Zanesi N, Datta J, Roy S, Kutay H, Checovich AM, Kaou M, Zhong Y, Johnson AJ, Lucas DM, Heerema NA, Hagan J, Mo X, Jarjoura D, Byrd JC, Croce CM, Jacob ST: AP-1 elements and TCL1 protein regulate expression of the gene encoding protein tyrosine phosphatase PTPROt in leukemia. Blood 118(23): 6132-40, Dec 2011.
2010
Yiming Zhong, Brent Sullenbarger, Larry C. Lasky.: Effect of increased HoxB4 on human megakaryocytic development. Biochemical and Biophysical Research Communications 398(3): 377-382, Jul 2010.
2003
ZHONG Yiming, JIANG Guanghuai, CHEN Xuewei, XIA Zhihui, LI Xiaobing, ZHU Lihuang, ZHAI Wenxue: Identification and gene prediction of a 24 kb region containing xa5, a recessive bacterial blight resistance gene in rice (Oryza sativa L.). CHINESE SCIENCE BULLETIN 48(24): 2725-2729, Dec 2003.