Jessica W. Wen, MD
Areas of expertise: Viral hepatitis, Biliary atresia, ARPKD/congenital hepatic fibrosis, Liver disease
Locations: Main Building, Buerger Center for Advanced Pediatric Care, Specialty Care, Bryn Mawr
About Jessica W. Wen, MD
Titles
Director, Viral Hepatitis Treatment Program
Associate Professor of Clinical Pediatrics (Gastroenterology, Hepatology and Nutrition), Perelman School of Medicine at the University of Pennsylvania
Certifications
Pediatric Gastroenterology – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Awards and Honors
2013-2015, 2017, Fellows Faculty Honor Roll, Children's Hospital of Philadelphia, Division of Gastroenterology, Hepatology & Nutrition
2012-2014, University of Pennsylvania Master of Translational Research Fellowship
2012, Young Faculty Clinical Investigator Award/ North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
2011, American Association for the Study of Liver Disease(AASLD)/American Liver Foundation(ALF) Liver Scholar Award
2011, Studies of Pediatric Liver Transplantation (SPLIT) Annual Meeting Young Faculty Travel Award
2010, North American Society for Pediatric Gastroenterology, Hepatology & Nutrition (NASPGHAN) Annual Meeting 2010 Poster of Distinction
2010, AASLD Annual Meeting Young Investigator Travel Award
2009-2011, NIH NRSA F32 Individual Research Training Fellowship
2009-2010, Chief Fellow, The Children's Hospital Pediatric GI Fellowship Program
2008-2012, NIH Loan Repayment Program
2008-2009, NIH NRSA T32 Institution Training Fellowship
1999-2000, MIT Undergraduate Research Opportunities Program Direct Research Funding with Howard Hughes Medical Institute
Leadership and Memberships
Memberships in professional organizations
International
2007-present, North American Society for Pediatric Gastroenterology, Hepatology and Nutrition
- 2023-present, Hepatology Committee
National
2018-present, Society of Pediatric Liver Transplant
2015-present, American Society of Transplantation
2007-present, American Association For The Study of Liver Disease (AASLD)
Editorial and Academic Positions
Academic and Institutional Committees
2019-present, Bylaws Committee
2017-present, Credentialing Committee
2016-present, GI Division Research Interest Steering Committee
Research Interests
Hepatitis B and hepatitis C
Liver fibrosis
Congenital hepatic fibrosis/autosomal recessive polycystic kidney disease
Education & training
Medical Degree
MD - Baylor College of Medicine, Houston, TX
Residency
Pediatrics - Texas Children's Hospital/Ben Taub General Hospital, Houston, TX
Fellowship
Pediatric Gastroenterology - The Children's Hospital of Philadelphia, Philadelphia, PA (Chief Fellow)
Publications
Publications
2022
Ritter AL, Gold J, Hayashi H, Ackermann AM, Hanke S, Skraban C, Cuddapah S, Bhoj E, Li D, Kuroda Y, Wen J, Takeda R, Bibb A, El Chehadeh S, Piton A, Ohl J, Kukolich MK, Nagasaki K, Kato K, Ogi T, Bhatti T, Russo P, Krock B, Murrell JR, Sullivan JA, Shashi V, Stong N, Hakonarson H, Sawano K, Torti E, Willaert R, Si Y, Wilcox WR, Wirgenes KV, Thomassen K, Carlotti K, Erwin A, Lazier J, Marquardt T, He M, Edmondson AC, Izumi K.: Expanding the Phenotypic Spectrum of ARCN1-related syndrome. Genet Med 24(6): 1227-1237, Jun 2022.
2021
Clarkston, K., Lee, J., Donoghue, S., Peters, H., Eiroa, H., Shah, A.A., Loomes, K., Wen, J., Oliver, M., Hardikar, W., Prada, C.E., Asai, A.: Acute liver dysfunction with delayed peak of serum aminotransferase levels as a presentation of ornithine transcarbamylase deficiency in females. AM J Med Genet 185(3): 909-915, 3 2021.
Hartung, E.A., Calle-Toro, J.S., Lopera, C.M., Wen, J., Carson, R.H., Dutt, M., Howarth, K., Furth, S.L., Darge, K., Serai, S.D. : Magnetic resonance elastography to quantify liver disease severity in autosomal recessive polycystic kidney disease. Abdom Radiol 46(2): 570-580, 2 2021.
Jonas, M.M., Rhee, S., Kelly, D.A., Del Valle-Segarra, A., Feiterna-Sperling, C., Gilmour, S., Gonzalez-Peralta, R.P., Hierro, L., Leung, D.H., Ling, S.C., Lobzin, Y., Lobritto, S., Mizuochi, T., Narkewicz, M.R., Sabharwal, V., Wen, J., Lon, H.K., Marcinak, J., Topp, A., Tripathi, R., Sokal, E.: Pharmacokinetics, safety, and efficacy of glecaprevir/pibrentasvir in children with chronic hepatitis C virus: part 2 of the DORA study Hepatology 74(1): 19-27, 7 2021.
2020
Mody, S., Rosenthal,P.,Narkewicz, M.R., Yao, B.B., Jolley, C.D., Lobritto, S.J., Wen, J., Molleston, J.P., Hsu, E.K., Jonas, M.M., Zha, J., Liu, L., and Leung, D.H. : Ombitasvir, Paritaprevir, Ritonavir and Dasabuvir Mini-tabs +/- Ribavirin for Children Aged 3-11 Years With Hepatitis C. Adv Ther. 37(7): 3299-3310, July 2020.
2019
Hartung EA, Wen J, Poznick L, Furth SL, Darge K.: Ultrasound Elastography to Quantify Liver Disease Severity inAutosomal Recessive Polycystic Kidney Disease. J Pediatr 209: 107-115, June 2019.
2018
Murray, K.F., Balistreri, W. F., Bansal, S., Whitworth, S., Evans, H.M., Gonzalez-Peralta, R.P., Wen, J., Massetto, B., Kersey, K., Shao, J., Garrison, K.L., Parhy, B., Brainard, D.M., Arnon, R., Gillis, L., Jonas, M.M., Lin, C.H., Narkewicz, M.R., Schwarz, K., Rosenthal, P.: Safety and Efficacy of Ledipasvir-Sofosbuvir With or Without Ribavirin for Chronic Hepatitis C in Children Ages 6-11. Hepatology Aug 2018.
2016
Balistreri1 WF, Murray KF, Rosenthal P, Bansal S, Lin HC, Kersey K, Massetto B, Zhu Y, Kanwar B, German P, Svarovskaia E, Brainard DM, Wen J, Gonzalez-Peralta RP, Jonas MM, and Schwarz K: The safety and effectiveness of Ledipasvir-Sofosbuvir in adolescents 12 to 17 Years old with hepatitis C virus genotype 1 infection. Hepatology. 2016 Dec 20. doi: 10.1002/hep.28995. [Epub ahead of print]
Muir A, Otero H, Blinman T, Wen J: Use of MRI with hepatobiliary specific contrast agent for precise localization of bile duct leak. J Pediatr Gastroenterol Nutr 63(3): e36, September 2016 Notes: DOI: 10.1097/MPG.0000000000000531
Schwarz K. Molleston JP, Jonas MM, Wen J, Murray K, Rosenthal P, Gonzalez-Peralta RP, Lobritto SJ, Mogul D, Hooper G, Warne C, Thompson B: Durability of response in children treated with pegylated interferon alfa-2a +/- ribavirin for chronic hepatitis C. J Pediatr Gastroenterol Nutr 62(1): 93-6, Jan 2016.
2015
Stoddard MB, Li H, Wang S, Saeed M, Andrus L, Ding W, Jiang X, Learn GH, von Schaewen M, Wen J, Goepfert PA, Hahn BH, Ploss A, Rice CM, Shaw GM.: Identification, molecular cloning, and analysis of full-length hepatitis C virus transmitted/founder genotypes 1, 3, and 4. MBio. 6(2): e02518-14, Febuary 2015.
2014
Jonas MM, Schwarz KB, Gonzalez-Peralta R, Lobritto S, Molleston JP, Murray KF, Rosenthal P, Wen J, Wat C, Pavlovic V, Warne C: Long-term growth outcomes in children treated for chronic hepatitis C J Pediatr 165(6): 1252-4, December 2014.
Wen JW, Furth SL, Ruebner RL: Kidney and liver transplantation in children with fibrocystic liver-kidney disease: Data from the US Scientific Registry of Transplant Recipients: 1990-2010. Pediatric Transplantation 18(7): 726-32, November 2014.
2012
Wen Jessica, Friedman Joshua R: miR-122 regulates hepatic lipid metabolism and tumor suppression. The Journal of clinical investigation 122(8): 2773-6, Aug 2012. PMCID: PMC3408753.
2011
Wen, J.: Congenital Hepatic Fibrosis in Autosomal Recessive Polycystic Kidney Disease. Clinical and Translational Science 4(6): 460-465, December 2011.
Abstracts (includes Posters and Scientific Presentations)
2023
Leung DH, Whitworth S, Wen J et al.: Long-Term Safety and Efficacy of Sofosbuvir-Based Direct-Acting Antivirals in Pediatric Patients With Hepatitis C Virus. AASLD: The Liver Meeting 2023 2023.
2022
Wen, J., Whitworth, S., Leung, D.H., Rosenthal, P., Lin, C.H., Karnsaku, W., Bansal, S., Arnon, R., Romero, R., Rao, G.S., Narkewicz, M.R., Honegger, J.R., Jolly, C., Jonas, M.M., Shao, J., Brainard, D.M., Kersey, K., Gaggar, A., Balistreri, W.F., Hardikar, W., Gonzalez-Peralta, R.P.: Long term follow-up of safety and efficacy of sofosbuvir-based treatments for chronic HCV infection in pediatric patients. 54th Annual Meeting of ESPGHAN June 2022.
2021
Mizuochi, T., Jonas, M.M., Rhee, S., Kelly, D.A., Del Valle-Segarra, A., Feiterna-Sperling, C., Gilmour, S., Gonzalez-Peralta, R., Hierro, L., Leung, D.H., Ling, S.C., Lobzin, Y., Lobritto, S., Narkewicz, M.R., Sabharwal, V., Wen, J., Lon, H.K., Marcinak, J., Topp, A., Tripathi, R., Sokal, E.: Safety and efficacy of glecaprevir/pibrentasvir in pediatric patients with genotypes 1-6 chronic hepatitis C virus (HCV) infection: part 2 of the DORA study. Japan Society of Hepatology - 57th Annual Meeting June 2021.
Wen, J., Whitworth, S., Leung, D., Rosenthal, P., Lin, C.H., Karnsakul, W., Bansal, S., Arnon, R., Romero,R., Rao, G.S., Narkewicz, M.R., Honegger, J.R., Jolly, C., Jonas, M., Shao, J., Gaggar, A., Kersey, K., Balistreri, W.F., Hardikar, W., Gonzalez-Peralta, R.P.: Long term follow-up of safety and efficacy of sofosbuvir-based HCV DAAs in pediatric patients Asian Pacific Association for the Study of the Liver (APASL) Annual Meeting 2021.
Lectures by Invitation
2022
Wen, J. "Chronic viral hepatitis in children." The Children's Hospital of Philadelphia Division of Infectious Disease Journal Club. Dec 2022.
Books
2014
Ruchelli, E.D., Wen, J.W., Rand, E.B. : Hepatitis and Liver Failure in Infancy and Childhood. Pathology of Pediatric Gastrointestinal and Liver Disease. Russo, P., Ruchelli, E., Piccoli, D. (eds.). March 2014.
Editorials, Reviews, Chapters
2022
Ruchelli, E.D., Wen, J.W.: Hepatitis and Liver Failure in Infancy and Childhood. Pathology of Pediatric Gastrointestinal and Liver Disease. Russo, P., Ruchelli, E., Piccoli, D. (eds.). 2022 Notes: In press.
Wen J, Liacouras C: Chapters on peritonitis and chylous ascites. Nelson Textbook of Pediatrics, 21st Ed 2022 Notes: In press.
2015
Wen J, Liacouras C: Chapters on peritonitis and chylous ascites Nelson Textbook of Pediatrics, 20th Ed Kliegman RM (eds.). Elsevier, May 2015.
2014
Ruchelli E, Wen J, Rand E : Hepatitis and liver failure in infancy and childhood. Pathology of Pediatric Gastrointestinal and Liver Disease, 2nd Edition. Russo P, Ruchelli E, Piccoli D (eds.). Springer, June 2014.
2012
Wen, J. & Fernando del Rosairo, J.: Chapter on Congenital Hepatic Fibrosis. 5 Minute Pediatric Consult, 6th ed. M. William Schwartz (eds.). Lippincott Williams & Wilkins, Page: 214-215, 2012.
2011
Wen, J. & Liacouras, C: Chapters on Peritonitis and Chylous Ascites. Nelson Textbook of Pediatrics, 19th Ed. Kliegman, R.M. et al. (eds.). Elsevier, Page: 1416-1418, 2011.
Wen, J. & Graham R.: Chapter on Inflammatory Bowel Disease. Netter's Pediatrics Florin, T. & Ludwig, S. (eds.). Elsevier, Page: 698-703, June 2011.
Wen, J. & Piccoli, D.: Biliary Tree- Normal Anatomy, Development, Physiology, and Microanatomy The NASPGHAN Fellows Concise Review of Pediatric Gastroenterology, Hepatology and Nutrition. Sondheimer, J. & Waasdorp Hurtado, C. (eds.). Castle Connolly Graduate Medical Publishing, Ltd, Page: 207-208, 2011.