Christopher S. Thom, MD, PhD
Locations: Main Building
About Christopher S. Thom, MD, PhD
Titles
Attending Physician
Assistant Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Certifications
Neonatal-Perinatal Medicine – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Awards and Honors
2024, Children’s Hospital of Philadelphia Foerderer Award
2023, Hartwell Foundation Individual Biomedical Research Award
2022, Eastern Society for Pediatric Research Young Investigator Travel Award
2021, American Academy of Pediatrics Section on Neonatal and Perinatal Medicine Young Investigator Award
2021, American Academy of Pediatrics Section on Neonatal and Perinatal Medicine Travel Grant
2020, 62nd American Society of Hematology Conference Abstract Achievement Award
2020, Society for Pediatric Research Fellows’ Basic Research Award
2020, Eastern Society of Pediatric Research Trainee Young Investigator Award
2020, The Children’s Hospital of Philadelphia Distinguished Research Trainee Award
2019, 61st American Society of Hematology Conference Abstract Achievement Award
2019, American Academy of Pediatrics Trainees and Early Career Neonatologists Travel Award
2019, Philadelphia Perinatal Society Thomas R Boggs Award for Neonatal-Perinatal Research
2019, American Academy of Pediatrics Marshall Klaus Perinatal Research Award
2018, UPenn Biomedical Council Postdoc Symposium Sanjeev Kumar Memorial Award Finalist
2017, Senior Resident Research Award, The Children’s Hospital of Philadelphia
2014, Adolph J. Creskoff Paper Prize for Research in Hematology, Perelman School of Medicine at the University of Pennsylvania
2013, Best Speaker Award (2012-2013), Abramson Family Cancer Research Institute/UPenn Cancer Biology Program Student Seminar Series
2013, Cancer Biology Student Poster Award, 17th Annual University of Pennsylvania Cell and Molecular Biology Graduate Group Symposium
2013, Alexandra Kefalides Award, University of Pennsylvania Abramson Family Cancer Center Hematologic Malignancies Program & The Children’s Hospital of Philadelphia Research Institute Normal and Malignant Hematopoiesis Research Affinity Group
2013, Edward Holmes Award for Bench Research, Hospital of the University of Pennsylvania Department of Medicine
2013, Research Poster Day Award, The Children’s Hospital of Philadelphia
2012, 54th American Society of Hematology Conference Abstract Achievement Award
2012, Research Poster Award, 18th Hemoglobin Switching Meeting, Pacific Grove, CA
2011, Research Poster Day Award, The Children’s Hospital of Philadelphia
Leadership and Memberships
Memberships in Professional Organizations
2024-present, American Society of Human Genetics
2023-present, American Heart Association
2019-present, American Academy of Pediatrics Trainees and Early Career Neonatologists
2019-present, American Society of Hematology
2017-present, Society for Pediatric Research
2015-present, American Academy of Pediatrics
Research Interests
Chris Thom Lab >
Education & training
Graduate Degree
PhD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Medical Degree
PhD - Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA
Residency
Pediatrics - Children’s Hospital of Philadelphia, Philadelphia, PA
Fellowship
Neonatology - Children’s Hospital of Philadelphia, Philadelphia, PA
Publications
Publications
2024
Visner M^. Phosphoproteomics reveals content and signaling differences between neonatal and adult platelets. Journal of Thrombosis and Haemostasis, 2024 May;22(5):1447-1462. PMID: 38160730. PMCID: PMC11055671. Associated commentary by Babur et al. *co-first ^co-corresponding
Pavani G, Klein JG, Nations CC, Sussman JH, Tan K, An HH, Abdulmalik O, Thom CS, Gearhart PA, Willet CM, Maguire JA, Chou ST, French DL, Gadue P. Modeling primitive and definitive erythropoiesis with induced pluripotent stem cells. Blood Adv, 2024 Mar 26;8(6):1449-1463. PMID: 38290102.
Hui D, Sanford E, Lorenz K, Damrauer SM, Assimes TL, Thom CS, Voight BF. Mendelian randomization analyses reveal mediating factors for the causal effect of height on cardiovascular diseases. PLoS One 2024, Jul 3;19(7):e0298786. PMID 38959188.
Qiu R, Petit C, Thom CS. Nuclear isolation from cryopreserved in vitro derived blood cells. Journal of Visualized Experiments, 2024 Mar 15;(205):10.3791/66490. PMID: 38558008. PMCID: PMC11190953.
Wilken MB, Fonar G, Qiu R, Bennett L, Tober J, Nations C, Pavani G, Nations C, Tsao V, Garifallou J, Petit C, Maguire JA, Gagne A, Okoli N, Gadue P, Chou ST, French DL, Speck NA, Thom CS. Tropomyosin 1 deficiency facilitates cell state transitions and enhances hemogenic endothelial cell specification during hematopoiesis. Stem Cell Reports 2024; Aug 20:S2213-6711(24)00222-4. PMCID: PMC10491315.
Shivakumar S, Wilken MB, Tsao V, Bitarello B, Thom CS^. Smoking behavior impacts genetic erythroid trait variation via alcohol intake. PloS One 2024; Sep 5;19(9):e0309608. PMID: 39236005. PMCID: PMC11376579. ^corresponding
2023
Wilken MB, Maguire JA, Dungan LV, Gagne A, Osorio-Quintero C, Waxman EA, Chou ST, Gadue P, French DL, Thom CS. Generation of a human Tropomyosin 1 knockout iPSC line. Stem Cell Research 2023 Jun 28;71:103161.PMID: 37422949. PMCID: PMC10507314.
Dulmovits BM, Wild KT, Flibotte JJ, Lambert MP, Kwiatkowski J, Thom CS. Prolonged neonatal thrombocytopenia as a presenting finding in de novo pyruvate kinase deficiency. Neonatology 2023 July 20;1-5. PMID: 37473739. PMCID: PMC11027091.
2022
Thom CS, Wilken MB, Chou ST, Voight BF. Body mass index and adipose distribution have opposing genetic impacts on human blood traits. eLife. 2022 Feb 15;11:e75317. PMID: 35166671.
2021
Gu H, Devine M, Hedrick HL, Rintoul NE, Thom CS. High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients. Platelets. 2021 Oct 26;1-3. PMID: 34697983.
2020
Thom CS, Deshmukh H, Soorikian L, Jacobs I, Fiadjoe J, Lioy J. Airway emergency management in a pediatric hospital before and during the COVID-19 pandemic. International Journal of Pediatric Otorhinolaryngology. 2020 Dec;139:110458. PMID: 33130467.
Thom CS, Echevarria E, Osborne AD, Carr L, Rubey K, Salazar E, Callaway D, Pawlowski T, Devine M, Kleinman S, Flibotte J, Lambert MP. Extreme thrombocytosis is associated with critical illness and young age, but not increased thrombotic risk, in hospitalized pediatric patients. Journal of Thrombosis and Haemostasis. 2020 Sep 26;10.1111/jth.15103. PMID: 32979018.
Thom CS, Ding Z, Levin MG, Damrauer SM, Lee KM, Lynch JA, Chang KM, Tsao PS, Cho K, Wilson PWF, Assimes TL, Sun YV, O’Donnell CJ, VA Million Veteran Program, Vujkovic M, Voight BF. Genetic determinants of increased body mass index mediate the effect of smoking on increased risk for type 2 diabetes risk but not coronary artery disease. Human Molecular Genetics. 2020. Aug 24;ddaa193. PMID: 32833022.
Thom CS, Voight BF. Genetic colocalization atlas points to common regulatory sites and genes for hematopoietic traits and hematopoietic contributions to disease phenotypes. BMC Medical Genomics. 2020. Jun 29;13(1):89. PMID: 32600345.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, Gagne A, Gadue P, French DL, Voight BF. Tropomyosin 1 genetically constrains in vitro hematopoiesis. BMC Biology. 2020. May 14;18(1):52. PMID: 32408895.
Thom CS, Brandsma E, Lambert MP. Thrombocytosis in an infant with a TRPV4 mutation: a case report. Platelets. 2020 Apr 22:1-3. PMID 32319342. PMCID: PMC6982552.
Thom CS, Devine M, Kleinman S, Jensen EA, Lambert MP, Padula MA. Neonatal platelet count trends during inhaled nitric oxide therapy. British Journal of Haematology. 2020 Feb;188(3):e28-e30. PMID 31840227.
2019
Lechauve C, Keith J, Khandros E, Fowler S, Mayberry K, Freiwan A, Thom CS, Delbini P, Romero EB, Zhang J, Motta I, Tillman H, Cappellini MD, Kundu M, Weiss MJ. Unc 51–like autophagy-activating kinase (ULK1) mediates clearance of free α-globin in β-thalassemia. Sci Transl Med. 2019 Aug 21;11(506). PMID 31434755.
2018
Traxler EA, Thom CS, Yao Y, Paralkar V, Weiss MJ. Non-specific inhibition of erythropoiesis by short hairpin RNAs. Blood. 2018 Jun 14;131(24):2733-2736. PMID 29728407.
Romasko EJ, Devkota B, Biswas S, Jayaraman V, Rajagopalan R, Dulik M, Thom CS, Choi J, Jairam S, Scarano MI, Spinner NB, Krantz ID, Conlin LK, Lambert MP. Utility and limitations of exome sequencing in the molecular diagnosis of pediatric inherited platelet disorders. American Journal of Hematology. 2018 Jan;93(1):8-16. PMID 28960434.
2017
Vo KK, Jarocha DJ, Lyde RB, Hayes V, Thom CS, Sullivan SK, French DL, Poncz M. FLI1 level during megakaryopoiesis affects thrombopoiesis and platelet biology. Blood. 2017 Jun 29;129(26):3486-3494. PMID: 28432223.
2014
Thom CS, Traxler EA, Khandros E, Nickas JM, Zhou OY, Lazarus JE, Silva APG, Prabhu D, Aribeana C, Fuchs SY, Mackay JP, Holzbaur ELF, Weiss MJ. Trim58 degrades dynein and regulates terminal erythropoiesis. Developmental Cell. 2014 Sep 29:30(6):688-700. PMID: 25241935.
Mora-Blanco EL, Mishina Y, Tillman EJ, Cho YJ, Thom CS, Pomeroy SL, Shao W, Roberts CW. Activation of b-catenin/TCF targets following loss of the tumor suppressor SNF5. Oncogene. 2014 Feb 13;33(7):933-938. PMID: 23435428.
2013
Zou Z, Enis DR, Bui H, Khandros E, Kumar V, Jakus Z, Thom CS, Yang Y, Dhillon V, Chen M, Lu M, Weiss MJ, Kahn ML. The secreted lymphangiogenic factor CCBE1 is essential for fetal liver erythropoiesis. Blood. 2013 April 18;121(16):3228-36. PMID: 23426945.
2012
Khandros E, Thom CS, D’Souza J, Weiss MJ. Integrated protein quality control pathways regulate free a globin in murine b-thalassemia. Blood. 2012 May 31;119(22):5265-75. PMID: 22427201.
2011
Wang X, Werneck M, Wilson B, Kim H, Kluk M, Thom CS, Wischhusen J, Evans J, Jesneck J, Nguyen P, Sansam CG, Cantor H, Roberts CW. T cell receptor dependent transformation of mature memory phenotype T cells in mice. Journal of Clinical Investigation. 2011 Oct;121(10):3834-45. PMID: 21926465.
2009
Wang X, Sansam CG, Thom CS, Metzger D, Evans JA, Nguyen PT, Roberts CW. Oncogenesis caused by loss of the SNF5 tumor suppressor is dependent on the activity of BRG1, the ATPase of the SWI/SNF chromatin remodeling complex. Cancer Research. 2009 Oct 15;69(20):8094-101. PMID: 19789351.
2008
McKenna ES, Sansam CG, Cho YJ, Greulich H, Evans JA, Thom CS, Moreau LA, Biegel JA, Pomeroy SL, Roberts CW. Loss of the epigenetic tumor suppressor SNF5 leads to cancer without genomic instability. Molecular and Cellular Biology. 2008 Oct;28(20):6223-33. PMID: 18710953.
Abstracts (includes Posters and Scientific Presentations)
2024
Coletti K, Hershey JA, Devin MD, Friedman D, Lambert MP, Gibbs K, Schinella J, Taft J, Ajiboye S, Zierk A, Thom CS. Less is More! Standardized platelet transfusion practices in the NICU safely reduces prescribed transfusion volumes. Eastern Society of Pediatric Research Annual Scientific Meeting (Philadelphia, PA).
Gilmore L, Chou ST, Ghavam S, Thom CS. Consensus Transfusion Guidelines for a Large Neonatal Care Network. Eastern Society of Pediatric Research Annual Scientific Meeting (Philadelphia, PA).
Fonar G, Thom CS. Science Slam Flash Talk. Children’s Hospital of Philadelphia Research Institute Scientific Symposium (Philadelphia, PA).
2023
Davenport P, Thom CS, Soule-Albridge E, Nolton E, Liu ZJ, Feldman HA, Sola-Visner MC. Developmental Differences between Neonatal and Adult Platelets in Regard to Immune Protein Content and Regulation of Monocyte Inflammatory Responses. Platform presentation at the American Society of hematology Annual Meeting (San Diego, CA).
2022
Thom CS, Wilken MB, Chou ST, Voight BF. Obesity and adipose distribution impact genetically determine blood traits. Platform presentation at the 1st Annual Eastern Medical Research Conference (Virtual).
Wilken MB, Voight BF, Chou ST, French DL, Thom CS. Endothelial expansion contributes to enhanced blood cell production from Tropomyosin 1-deficient induced pluripotent stem cells. Platform presentation at the 1st Annual Eastern Medical Research Conference (Virtual).
2021
Thom CS, Soorikian L, Jacobs I, Fiadjoe J, Lioy J. Airway emergency management before and during COVID-19. 50th Society of Critical Care Medicine Congress (Virtual).
Thom CS and Voight BF. Blood trait regulatory genes and hematopoietic contributions to disease phenotypes revealed through genetic colocalization analysis. 33rd Eastern Society for Pediatric Research Annual Scientific Meeting (Virtual).
Thom CS, Jobaliya C, Wilken M, Voight BF, Chou ST, French DL. Endothelial expansion contributes to enhanced blood cell production from Tropomyosin 1 deficient induced pluripotent stem cells. American Academy of Pediatrics National Conference & Exhibition, Philadelphia, PA.
2020
Thom CS, Jobaliya CD, Voight BF, Chou ST, French DL. Manipulation of Tropomyosin 1 in iPSCs to enhance in vitro blood cell production, 62nd American Society of Hematology Annual Meeting (Virtual). 2020.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Advancing in vitro hematopoiesis through genetic enhancement. NHLBI Progenitor Cell Translational Consortium Blood Progenitor Group Meeting, Boston, MA (Virtual). 2020.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Tropomyosin 1 genetically constrains hematopoiesis. Eastern Society for Pediatric Research Meeting, Philadelphia, PA (Virtual). 2020.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Tropomyosin 1 genetically constrains hematopoiesis. Pediatric Academic Societies Meeting, Philadelphia, PA (Virtual). 2020.
Thom CS. Blood trait regulatory sites and genes revealed through genetic colocalization analysis. NIDDK Bioinformatic Exploration of Hematology Cohort Data Webinar, Rockville, MD (Virtual). 2020.
Thom CS. Manipulating Tropomyosin 1 in iPSCs to enhance in vitro hematopoiesis. 4th Annual NHLBI Progenitor Cell Translational Consortium Annual Conference, Philadelphia, PA (Virtual). 2020.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Advancing in vitro hematopoiesis through genetic enhancement. NHLBI Progenitor Cell Translational Consortium Blood Progenitor Group Meeting, Boston, MA (Virtual). 2020.
2019
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Machine learning reveals genetic determinants of platelet traits. University of Pennsylvania Platelet Club, Philadelphia, PA. 2019.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Tropomyosin 1 genetically constrains hematopoiesis. Philadelphia Perinatal Society Meeting, Philadelphia, PA. 2019.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Tropomyosin 1 genetically constrains hematopoiesis and megakaryocyte development. The Children’s Hospital of Philadelphia Research Symposium, Philadelphia, PA. 2019.
Thom CS, Soorikian L, Jacobs I, Fiadjoe JE, and Lioy J. Longitudinal Experience with Airway Emergencies in a Large Pediatric Hospital. 9th International Symposium on the Pediatric Airway, Geneva University, Geneva, Switzerland. 2019.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Tropomyosin 1 genetically constrains hematopoiesis. 3rd Annual NHLBI Progenitor Cell Translational Consortium Conference, Boston, MA. 2019.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Tropomyosin 1 constrains hematopoiesis from iPSCs. UPenn/CHOP Induced Pluripotent Stem Cell Club Meeting, Philadelphia, PA. 2019.
Thom CS, Soorikian L, Jacobs I, Fiadjoe JE, and Lioy J. Longitudinal Experience with Airway Emergencies in a Large Pediatric Hospital. Eastern Society for Pediatric Research Annual Scientific Meeting, Philadelphia, PA. 2019.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Tropomyosin 1 genetically constrains hematopoiesis. University of Pennsylvania Post-doctoral Council Research Symposium, Philadelphia, PA. 2019.
Thom CS, Soorikian L, Jacobs I, Fiadjoe JE, and Lioy J. Longitudinal Experience with Airway Emergencies in a Large Pediatric Hospital. 11th Children’s Hospitals Neonatal Consortium Annual Symposium, Atlanta, GA. 2019.
Thom CS, Jobaliya CD, Lorenz K, Maguire JA, French DL, Voight BF. Tropomyosin 1 genetically constrains hematopoiesis. 61st American Society of Hematology Annual Meeting, Orlando, FL. 2019.
Lectures by Invitation
2024
Thom CS. Research and Career Opportunities in Neonatology. University of South Carolina Pediatric Medicine Group, Columbia, SC, USA (Virtual)
2023
Thom CS. Translational Opportunities in Neonatal Hematology and Transfusion Medicine. NHLBI Celebration of Progenitor Cell Research and Translation, Bethesda, MD, USA.
2022
Thom CS. Unraveling genetic determinants of blood traits. Harvard Program in Neonatology Newborn Medicine Research Seminar (Virtual)
2021
Thom CS. Genetic approaches to increase in vitro blood cell production. Yale School of Medicine Neonatology Research Seminar (Virtual). 2021.
2020
Thom CS. Using genetic insights to make more blood cells. The Children’s Hospital of Philadelphia Neonatology Research Seminar Series, Philadelphia, PA. 2020.
Thom CS. Using genetic insights to make more blood cells. The Children’s Hospital of Philadelphia Pediatric Grand Rounds, Philadelphia, PA. 2020.
Thom CS. Using genetic insights to make more blood cells. University of Rochester Medical Center Neonatology Research Seminar Series (Virtual). 2020.
Thom CS. Genetic approaches to increase in vitro blood cell production. Children’s Hospital of Philadelphia Neonatology Research Seminar (Virtual). 2020.
Thom CS. Genetic approaches to increase in vitro blood cell production. Cincinnati Children’s Hospital Medical Center Neonatology Research Seminar (Virtual). 2020.
Thom CS. Learning new platelet biology from babies and other patients. St. Christopher’s Hospital Neonatology Research Conference (Virtual). 2020.
Thom CS. Using genetic insights to make more blood cells. Cardeza Foundation for Hematologic Research Seminar Series, Thomas Jefferson University, Philadelphia, PA. 2020.
Editorials, Reviews, Chapters
2022
Gu H, Devine M, Hedrick HL, Rintoul NE, Thom CS: High rate of extreme thrombocytosis indicates bone marrow hyperactivity and splenic dysfunction among congenital diaphragmatic hernia patients. Platelets Page: 1-3, July 2022.
2014
Thom CS, Dickson CF, Gell DA, Weiss MJ. Normal and Abnormal Hemoglobins: Ch 19. In Orkin SH, Nathan DG, Ginsburg D, et al (eds): Hematology and Oncology of Infancy and Childhood, Eighth Edition. Philadelphia: Elsevier (Saunders), 2014 Dec 5.
2013
Thom CS, Dickson CF, Gell DA, Weiss MJ. Hemoglobin Variants: Biochemical Properties and Clinical Correlates. In Weatherall DJ, Schechter AN & Nathan DG (eds): Hemoglobin and Its Diseases. 2013. New York: Cold Spring Harbor Laboratory Press, March 1;3(3):a011858, pp 383-404. PMID: 23388674.