Lea F. Surrey, MD

2022

Bruehl FK, Kim AS, Li MM, Lindeman NI, Moncur JT, Souers RJ, Vasalos P, Voelkerding KV, Xian RR, Surrey LF: Tiered Somatic Variant Classification Adoption Has Increased Worldwide with Some Practice Differences Based on Location and Institutional Setting. Archives of Pathology and Laboratory Medicine Jan 2022 Notes: doi: 10.5858/arpa.2021-0179-CP [Epub ahead of print]

Devereaux KA, Souers RJ, Graham RP, Portier BP, Surrey LF, Yemelyanova A, Vasalos P, Trembath DG, Moncur JT: Neoplastic Cellularity Assessment in Molecular Testing. Archives of Pathology and Laboratory Medicine Jan 2022 Notes: Online ahead of print, doi: 10.5858/arpa.2021-0166-CP.

Tomás-Velázquez A, Surrey LF, Miele E, Li MM, Alaggio R, Goitz RJ, Reyes-Múgica M, Salgado CM: Mesenchymal PLAG1 Tumor With PCMTD1-PLAG1 Fusion in an Infant: A New Type of "Plagoma" American Journal of Dermatopathology 44(1): 54-57, Jan 2022.

2021

Lopez-Nunez O, Cafferata B, Santi M, Ranganathan S, Pearce TM, Kulich SM, Bailey KM, Broniscer A, Rossi S, Zin A, Nasrallah MP, Li MM, Zhong Y, Miele E, Alaggio R, Surrey LF: The spectrum of rare central nervous system (CNS) tumors with EWSR1-non-ETS fusions: experience from three pediatric institutions with review of the literature. Brain Pathology 31(1): 70-83, Jan 2021.

Lopez-Nunez O, Surrey LF, Alaggio R, Herradura A, McGough RL, John I: Novel APOD-GLI1 rearrangement in a sarcoma of unknown lineage. Histopathology 78(2): 338-340, Jan 2021.

Zhao X, Kotch C, Fox E, Surrey LF, Wertheim GB, Baloch ZW, Lin F, Pillai V, Luo M, Kreiger PA, Pogoriler JE, Linn RL, Russo PA, Santi M, Resnick AC, Storm PB, Hunger SP, Bauer AJ, Li MM: NTRK Fusions Identified in Pediatric Tumors: The Frequency, Fusion Partners, and Clinical Outcomes. JCO Precision Oncology 1, Jan 2021 Notes: ecollection 2021, doi: 10.1200/PO.20.00250.Kennedy GT, Sande CM, Surrey LF, Azari FS, Deshpande C, Singhal S: Anterior Mediastinal Neuroblastoma Associated with Syndrome of Inappropriate Antidiuretic Hormone Secretion: A Morphologic, Immunohistochemical, and Genetic Case Report and Review of the Literature. International Journal of Surgical Pathology Feb 2021 Notes: doi: 10.1177/10668969221080061 [Epub ahead of print]

Kundra R, Zhang H, Sheridan R, Sirintrapun SJ, Wang A, Ochoa A, Wilson M, Gross B, Sun Y, Madupuri R, Satravada BA, Reales D, Vakiani E, Al-Ahmadie HA, Dogan A, Arcila M, Zehir A, Maron S, Berger MF, Viaplana C, Janeway K, Ducar M, Sholl L, Dogan S, Bedard P, Surrey LF, Sanchez IH, Syed A, Rema AB, Chakravarty D, Suehnholz S, Nissan M, Iyer GV, Murali R, Bouvier N, Soslow RA, Hyman D, Younes A, Intlekofer A, Harding JJ, Carvajal RD, Sabbatini PJ, Abou-Alfa GK, Morris L, Janjigian YY, Gallagher MM, Soumerai TA, Mellinghoff IK, Hakimi AA, Fury M, Huse JT, Bagrodia A, Hameed M, Thomas S, Gardos S, Cerami E, Mazor T, Kumari P, Raman P, Shivdasani P, MacFarland S, Newman S, Waanders A, Gao J, Solit D, Schultz N: OncoTree: A Cancer Classification System for Precision Oncology. JCO Clinical Cancer Informatics 5, Feb 2021.

Lopez-Nunez O, Alaggio R, John I, Ciolfi A, Pedace L, Mastronuzzi A, Gianno F, Giangaspero F, Rossi S, Donofrio V, Cinalli G, Surrey LF, Tartaglia M, Locatelli F, Miele E: Melanotic Neuroectodermal Tumor of Infancy (MNTI) and Pineal Anlage Tumor (PAT) Harbor A Medulloblastoma Signature by DNA Methylation Profiling. Cancers (Basel) 13(4), Feb 2021.

Malige A, Surrey LF, Davidson R: Dorsal Medial Cuneiform Bony Outgrowth-Apophysis or Exostosis: A Case Report. JBJS Case Connect 11(1): e20.00194, Feb 2021.

Lalonde E, Rentas S, Wertheim G, Cao K, Surrey LF, Lin F, Zhao X, Obstfeld A, Aplenc R, Luo M, Li MM: Clinical impact of genomic characterization of 15 patients with acute megakaryoblastic leukemia-related malignancies. Cold Spring Harb Mol Case Stud 7(2), Apr 2021.

Jain P, Surrey LF, Straka J, Russo P, Womer R, Li MM, Storm PB, Waanders AJ, Hogarty MD, Resnick AC, Picarsic J: BRAF fusions in pediatric histiocytic neoplasms define distinct therapeutic responsiveness to RAF paradox breakers. Pediatric Blood & Cancer 68(6): e28933, Jun 2021 Notes: Surrey and Jain are co-first authors.

Ahmed AA, Habeebu S, Farooqi MS, Gamis AS, Gonzalez E, Flatt T, Sherman A, Surrey L, Arnold MA, Conces M, Koo S, Dioufa N, Barr FG, Tsokos MG: MYOD1 as a prognostic indicator in rhabdomyosarcoma. Pediatric Blood & Cancer 68(9): e29085, Sep 2021.

Killian K, Leckey BD, Naous R, McGough RL, Surrey LF, John I: Novel MEAF6-SUZ12 fusion in ossifying fibromyxoid tumor with unusual features. Genes Chromosomes and Cancer 60(9): 631-634, Sep 2021.

Hitt TA, Eisenberg J, Surrey LF, Gokli A, Semeao E, De Leon DD: Clinical case conundrum: Hyperlactataemia in a case of type 1 diabetes with chronic hyperglycaemia. Diabetic Medicine 38(10): e14629, Oct 2021.

Sudoko CK, Jenks CM, Bauer AJ, Isaza A, Mostoufi-Moab S, Surrey LF, Bhatti TR, Franco A, Adzick NS, Kazahaya K: Thyroid Lobectomy for T1 Papillary Thyroid Carcinoma in Pediatric Patients. JAMA Otolaryngology, Head and Neck Surgery 147(11): 943-950, Nov 2021.

Jia MR, Baran JA, Bauer AJ, Isaza A, Surrey LF, Bhatti T, McGrath C, Jalaly J, Mostoufi-Moab S, Adzick NS, Kazahaya K, Sisko L, Franco AT, Escobar FA, Krishnamurthy G, Patel T, Baloch Z: Utility of Fine-Needle Aspirations to Diagnose Pediatric Thyroid Nodules. Hormone Research in Paediatrics 94(7-8): 263-274, 2021.

2020

Balci TB, Strong A, Kalish JM, Zackai E, Maris JM, Reilly A, Surrey LF, Wertheim GB, Marcadier JL, Graham GE, Carter MT: Tatton-Brown-Rahman Syndrome: Six Individuals with Novel Features. American Journal of Medical Genetics 182(4): 673-680, Apr 2020.

Lopez-Nunez O, John I, Panasiti RN, Ranganathan S, Santoro L, Grélaud D, Wu T, Buccoliero AM, Casanova M, Alaggio R, Surrey LF: Infantile inflammatory myofibroblastic tumors: clinicopathological and molecular characterization of 12 cases. Modern Pathology 33(4): 576-590, Apr 2020.

Ryall S, Zapotocky M, Fukuoka K, Nobre L, Guerreiro Stucklin A, Bennett J, Siddaway R, Li C, Pajovic S, Arnoldo A, Kowalski PE, Johnson M, Sheth J, Lassaletta A, Tatevossian RG, Orisme W, Qaddoumi I, Surrey LF, Li MM, Waanders AJ, Gilheeney S, Rosenblum M, Bale T, Tsang DS, Laperriere N, Kulkarni A, Ibrahim GM, Drake J, Dirks P, Taylor MD, Rutka JT, Laughlin S, Shroff M, Shago M, Hazrati LN, D'Arcy C, Ramaswamy V, Bartels U, Huang A, Bouffet E, Karajannis MA, Santi M, Ellison DW, Tabori U, Hawkins C: Integrated Molecular and Clinical Analysis of 1,000 Pediatric Low-Grade Gliomas. Cancer Cell 37(4)(13): 569-583, Apr 2020.

Davis JL, Vargas SO, Rudzinski ER, López Marti JM, Janeway K, Forrest S, Winsnes K, Pinto N, Yang SE, VanSandt M, Boyd TK, Corless CL, Liu YJ, Surrey LF, Harris MH, Church A, Al-Ibraheemi A: Recurrent RET Gene Fusions in Pediatric Spindle Mesenchymal Neoplasms. Histopathology 76(7): 1032-1041, Jun 2020.

Franco AT, Labourier E, Ablordeppey KK, Surrey LF, Mostoufi-Moab S, Isaza A, Adzick NS, Kazahaya K, Kumar G, Bauer AJ: miRNA expression can classify pediatric thyroid lesions and increases the diagnostic yield of mutation testing. Pediatric Blood & Cancer 67(6): e28276, Jun 2020.

Trusty PM, Wei ZA, Rychik J, Graham A, Russo PA, Surrey LF, Goldberg DJ, Yoganathan AP, Fogel MA: Cardiac Magnetic Resonance Derived Metrics are Predictive of Liver Fibrosis in Fontan Patients. Annals of Thoracic Surgery  109(6): 1904-1911, Jun 2020.

Jain NK, Mostoufi-Moab S, Hawkes CP, Nelson ND, Surrey LF, Jones ZS, Adzick NS, Kazahaya K, Bauer AJ: Extrathyroidal Extension is an Important Predictor of Regional Lymph Node Metastasis in Pediatric Differentiated Thyroid Cancer. Thyroid 30(7): 1037-1043, Jul 2020.

Nasrallah MLP, Desai A, O'Rourke DM, Surrey LF, Stein JM: A dual-genotype oligoastrocytoma with histologic, molecular, radiological and time-course features. Acta Neuropathologica Communications 20(8): 115, Jul 2020.

Lopez-Nunez O, Surrey LF, Alaggio R, Fritchie KJ, John I: Novel PPP1CB-ALK fusion in spindle cell tumor defined by S100 and CD34 coexpression and distinctive stromal and perivascular hyalinization. Genes Chromosomes and Cancer 59(8): 495-499, Aug 2020.

2019

Merker JD, Devereaux K, Iafrate AJ, Kamel-Reid S, Kim AS, Moncur JT, Montgomery SB, Nagarajan R, Portier BP, Routbort MJ, Smail C, Surrey LF, Vasalos P, Lazar AJ, Lindeman NI: Proficiency Testing of Standardized Samples Shows Very High Interlaboratory Agreement for Clinical Next-Generation Sequencing-Based Oncology Assays. Archives of Pathology and Laboratory Medicine 143(4): 463-471, April 2019.

Surrey LF, MacFarland SP, Chang F, Cao K, Rathi KS, Akgumus GT, Gallo D, Lin F, Gleason A, Raman P, Aplenc R, Bagatell R, Minturn J, Mosse Y, Santi M, Tasian SK, Waanders AJ, Sarmady M, Maris JM, Hunger SP, Li MM.: Clinical utility of custom-designed NGS panel testing in pediatric tumors. Genome Medicine 11(1): 32, May 2019.

Surrey LF, Oakley FD, Merker JD, Long TA, Vasalos P, Moncur JT, Kim AS: Next-Generation Sequencing (NGS) Methods Show Superior or Equivalent Performance to Non-NGS Methods on BRAF, EGFR, and KRAS Proficiency Testing Samples. Archives of Pathology and Laboratory Medicine 143(8): 980-984, Aug 2019.

Chang F, Lin F, Cao K, Surrey LF, Aplenc R, Bagatell R, Resnick AC, Santi M, Storm PB, Tasian SK, Waanders AJ, Hunger SP, Li MM: Development and Clinical Validation of a Large Fusion Gene Panel for Pediatric Cancers. Journal of Molecular Diagnostics 21(5): 873-883, Sep 2019.

Picarsic J, Pysher T, Zhou H, Fluchel M, Pettit T, Whitehead M, Surrey LF, Harding B, Goldstein G, Fellig Y, Weintraub M, Mobley B, Sharples P, Sulis ML, Diamond EL, Jaffe R, Shekdar KV, Santi-Vicini M: BRAF-V600E Mutation in Juvenile Xanthogranuloma Family Neoplasms of the Central Nervous System (CNS-JXG): A revised diagnostic algorithm to include pediatric Erdheim-Chester Disease. Acta Neuropathologica Communications 7(1): 168, Nov 2019.

Shenoy A, Surrey L, Jain P, Foster J, Straka J, Resnick A, Waanders A, Luo M, Li M, Kazahaya K, Bagatell R, Wojcik J, Pogoriler J: Sclerosing Epithelioid Fibrosarcoma of the Bone With Rare EWSR1-CREB3L3 Translocation Driving Upregulation of the PI3K/mTOR Signaling Pathway. Pediatric and Developmental Pathology 22(6): 594-598, Nov-Dec 2019.

Surrey LF, Jain P, Zhang B, Straka J, Zhao X, Harding B, Resnick AC, Storm PB, Buccoliero AM, Genitori L, Li MM, Waanders AJ, Santi M: Genomic Analysis of Dysembryoplastic Neuroepithelial Tumor Spectrum Reveals a Diversity of Molecular Alterations Dysregulating the MAPK and PI3K/mTOR Pathways  Journal of Neuropathology and Experimental Neurology 78(12): 1100-1111, Dec 2019.

Szafranski P, Liu Q, Karolak JA, Song X, de Leeuw N, Faas B, Gerychova R, Janku P, Jezova M, Valaskova I, Gibbs KA, Surrey LF. Poisson V, Bérubé D,  Oligny LL, Michaud JL, Pope E, Stankiewicz P: Association of rare non-coding SNVs in the lung-specific FOXF1 enhancer with mitigation of the lethal ACDMPV phenotype. Human Genetics 138(11-12): 1301-1311, Dec 2019.

2018

Viaene AN, Santi M, Rosenbaum J, Li MM, Surrey LF, Nasrallah MP: SETD2 mutations in primary central nervous system tumors. Acta Neuropathol Commun 6(1): 123, Nov 2018.

MacFarland SP, Duffy K, Bhatti T, Bagatell R, Balamuth NJ, Brodeur GM, Ganguly A, Mattei P, Surrey LF, Balis FM, Kalish JM: Diagnosis of Beckwith-Wiedemann syndrome in children presenting with Wilms tumor. Pediatric Blood & Cancer 65(10): e27296, October 2018.

MacFarland S, Bauer AJ, Adzick NS, Surrey LF, Noyes J, Kazahaya K, Baloch Z, Mostoufi-Moab S: Disease Burden and Outcome in Children and Young Adults with Concurrent Graves Disease and Differentiated Thyroid Carcinoma. J Clin Endocrinol Metab 103(8): 2918-2925, Aug 1 2018.

Trusty PM, Wei Z, Rychik J, Russo PA, Surrey LF, Goldberg DJ, Fogel MA, Yoganathan AP: Impact of Hemodynamics and Fluid Energetics on Liver Fibrosis after Fontan Operation. Journal of Thoracic and Cardiovascular Surgery 156(1): 267-275, July 2018.

Jain P*, Surrey LF*, Straka J, Luo M, Lin F, Harding B, Resnick AC, Storm PB, Buccoliero AM, Santi M, Li MM, Waanders AJ: Novel FGFR2-INA Fusion Identified in Two Low-Grade Mixed Neuronal-Glial Tumors Drives Oncogenesis via MAPK and PI3K/mTOR Pathway Activation. Acta Neuropathologica 136(1): 167-169, Jul 2018 Notes: *Surrey and Jain are co-first authors.

Samuels SL, Surrey LF, Hawkes CP, Amberge M, Mostoufi-Moab S, Langer JE, Adzick NS, Kazahaya K, Bhatti TR, Baloch Z, LiVolsi VA, Bauer AJ: Characteristics of Follicular Variant Papillary Thyroid Carcinoma in a Pediatric Cohort. The Journal of Clinical Endocrinology & Metabolism 103(4): 1639-1648, April 2018.

2016

Canna SW, Girard C, Malle L, de Jesus A, Romberg N, Kelsen K, Surrey LF, Russo P, Sleight A, Schiffrin E, Gabay C, Goldbach-Mansky R, and Behrens EM: Life-threatening NLRC4-associated hyperinflammation successfully treated with Interleukin-18 inhibition. Journal of Allergy and Clinical Immunology November 2016.

Surrey LF, Russo P, Rychik J, Goldberg DJ, Dodds K, O'Byrne ML, Glatz AC, Rand EB, Lin HC.: Prevalence and characterization of fibrosis in surveillance liver biopsies of patients with Fontan circulation. Human Pathology 57: 106-115, November 2016.

Saul D, Degenhardt K, Iyoob SD, Surrey LF, Johnson AM, Johnson MP, Rychik J, Victoria T.: Hypoplastic left heart syndrome and the nutmeg lung pattern in utero: a cause and effect relationship or prognostic indicator? Pediatric Radiology 64(4): 483-489, April 2016.

Papasavvas E, Surrey LF, Glencross DK, Azzoni L, Joseph J, Omar T, Feldman MD, Williamson AL, Siminya M, Swarts A, Yin X, Liu Q, Firnhaber C, Montaner LJ.: High-risk oncogenic HPV genotype infection associates with increased immune activation and T cell exhaustion in ART-suppressed HIV-1-infected women. OncoImmunology 5(5): e1128612, Jan 2016.

2014

Surrey LF, Frank R, Zhang PJ, Furth EE: TTF-1 and Napsin-A are Expressed in a Subset of Cholangiocarcinomas Arising from the Gallbladder and Hepatic Ducts: Continued Caveats for Utilization of Immunohistochemistry Panels. American Journal of Surgical Pathology 38(2): 224-227, Feb 2014.

Sadri N, Surrey LF, Fraker DL, Zhang PJ: Retroperitoneal dedifferentiated liposarcoma lacking MDM2 amplification in a patient with a germ line CHEK2 mutation. Virchows Archive 464(4): 505-9, 2014.

2012

Cotticelli MG, Rasmussen L, Kushner NL, McKellip S, Sosa MI, Manouvakhova A, Feng S, White EL, Maddry JA, HeemskerkJ, Oldt RJ, Surrey LF, Ochs R, Wilson RB: Primary and Secondary Drug Screening Assays for Friedreich Ataxia. Journal of Biomolecular Screening 17(3): 303-313, March 2012.

Surrey LF, Thaker AA, Zhang PJ, Karakousis G, Feldman MD: Ectopic Functioning Adrenocortical Oncocytic Adenoma (Oncocytoma) with Myelolipoma Causing Virilization. Case Reports in Pathology 2012: 326418, 2012.

2010

Kim S, Yu A, Filippone L, Kolansky D, Raina A: Inverted-Takotsubo Pattern Cardiomyopathy Secondary to Pheochromocytoma: A Clinical Case and Literature Review. Clinical Cardiology 33(4): 200-5, 2010 Notes: This was published under her maiden name.

2004

Dobson-Stone C, Veleyos-Baeza A, Filippone LA, Westbury S, Storch A, Erdmann T, Wroe SJ, Leenders KL, Lang AE, Dotti MT, Federico A, Mohiddin SA, Fananapazir L, Daniels G, Danek A, Monaco AP: Corein Detection for the Diagnosis of Chorea-acanthocytosis. Annals of Neurology 56(2): 299-302, Aug 2004.

2020

Guerrero JC, Kreiger P, Surrey LF: Using Image-guided Needle Core Biopsies to Obtain Molecular Genetics in Pediatric Lymphatic-Vascular Malformation. Society for Pediatric Pathology Spring Meeting February 2020 Notes: Los Angeles, California; Poster.

Lopez-Nunez O, Alaggio R, Ciolfi A, Mastronuzzi A, Giangaspero F, Santoro L, Donofrio V, Surrey L, Miele E: Melanotic Neuroectodermal Tumor of Infancy (MNTI) Harbors a Medulloblastoma Signature by DNA Methylation Profiling. Society for Pediatric Pathology Spring Meeting February 2020 Notes: Platform Presentation; Los Angeles, California.

2019

Nya Nelson, Tricia Bhatti, Diana Corao, Dan Martinez, Bruce Pawel, Mariarita Santi, Lisa Sullivan, Paul J. Zhang, Lea F. Surrey: Pediatric Mismatch Repair Deficient Solid Tumors Detected by Immunohistochemistry are Rare but Enriched in the Central Nervous System: Implications for Checkpoint Inhibitor Therapy. Society for Pediatric Pathology Spring Meeting March 2019 Notes: Platform Presentation.

Nya Nelson, Mariarita Santi, Fumin Lin, Minjie Luo, Marilyn Li, Lea Surrey: Diagnostic Changes in Pediatric Tumors as a Result of Comprehensive Genomic Testing: An Institutional Experience. Society for Pediatric Pathology Spring Meeting March 2019 Notes: Platform Presentation.

2022

Surrey L. "Kinase-Altered Mesenchymal Spindle Cell Tumors: Algorithmic Approaches for Diagnosis and Therapeutic Target Identification", Session 3: Regulatory, Lab Diagnostics, Advocacy at Personalizing Pediatric Cancer Care: Innovation Through Collaboration, Philadelphia, PA. Mar 2022.

2021

Surrey L. "A Case of Neonatal Cushing Syndrome", United States and Canadian Academy of Pathology, Pediatric Pathology Evening Specialty Conference (given virtually due to COVID-19 pandemic). Mar 2021.

Surrey L. "Rising Stars: Novel Molecular Methods Poised to Move from the Research Laboratory to the Clinical Laboratory", Society for Pediatric Pathology Spring Symposium (given virtually due to COVID-19 pandemic). Mar 2021.

Surrey L. "Navigating the Muddy Molecular Waters: A guide for All Pathologists from Vintage to Millennial", Society for Pediatric Pathology Spring Meeting Symposium (given virtually due to COVID-19 pandemic). Mar 2021.

Surrey L. "Clinical Impact of Integrated Genomic Profiling for Pediatric Tumors: The CHOP Experience", St. Jude Children's Research Hospital, Memphis, TN (given virtually due to COVID-19 travel restrictions). Jan 2021.

2020

Surrey L. Surrey L. "Clinical Utility of Integrated Genomic Profiling for Pediatric Tumors", Lurie Children's Hospital, Chicago, Illinois (given virtually due to COVID-19 travel restrictions). Aug 2020.

Surrey L. "How Useful is it?: Genomic Profiling for Pediatric Tumors", Texas Children's Hospital, Houston, Texas (cancelled due to COVID-19). June 2020.

Surrey L. "How the Molecular Laboratory Enables Precision Medicine for Pediatric Tumors", Sidra Medicine, Doha, Qatar (Cancelled due to COVID-19). Apr 2020.

Surrey L. "Clinical Utility of Integrated Genomic Profiling for Pediatric Tumors", Children's Healthcare of Atlanta, Atlanta, Georgia. Jan 2020.

2019

Surrey L. "Clinical Utility of Integrated Genomic Profiling for Pediatric Tumors", British Columbia Children's Hospital, Vancouver, Canada. Apr 2019.

Surrey L. "Clinical Utility of Integrated Genomic Profiling for Pediatric Tumors", AI Dupont Hospital for Children, Wilmington, Delaware. Apr 2019.

2022

Surrey LF, Antonescu CR: Chapter 5.2.2.10 Inflammatory myofibroblastic tumour. In: WHO Classification of Tumours Editorial Board. Paediatric tumours (5th Edition). Alaggio RA, Lazar AJ, et al (eds.). International Agency for Research on Cancer, 7, 2022 Notes: In Press.

Surrey LF, Le Loarer F: Chapter 5.3.0.2 Round cell sarcoma with EWSR1-non-ETS fusions  In: WHO Classification of Tumours Editorial Board. Paediatric tumours (5th Edition). Alaggio R, Lazar AJ, et al (eds.). International Agency for Research on Cancer, 7, 2022 Notes: In press.