Rebecca A. Simmons, MD
Areas of expertise: Developmental aspects of glucose transport, Intrauterine growth retardation and diabetes
Locations: CHOP at Penn Medicine Hospital of the University of Pennsylvania, Main Building
About Rebecca A. Simmons, MD
Rebecca A. Simmons, MD, is the Hallam Hurt Professor of pediatrics at the Perelman School of Medicine at the University of Pennsylvania, with a joint appointment in the department of Obstetrics and Gynecology. She serves as the Director of the NIEHS funded Children’s Environmental Health Center, and the Deputy Director of the Center for Excellence in Environment and Toxicology funded by the NIEHS. She is a PI of the March of Dimes Preterm Birth Research Center at UPENN. Dr. Simmons is the past chair of the Faculty Senate at UPENN and is the Chair of Committee for Appointments and Promotions, Department of Pediatrics and Associate Chair of Faculty Affairs.
Dr. Simmons’s research focuses on the underlying molecular mechanisms that link the an abnormal intrauterine milieu associated with obesity, intrauterine growth restriction and environmental exposures on the long term health and disease risk in the offspring, She has been continuously funded by the NIH for over 30 years. Currently she is the principal investigator of a study entitled “Novel Biomarkers of Preterm Birth”; a study entitled “Placental Molecular Signature in Preterm Birth”. She was recently awarded an NIH grant: Novel Mechanisms Underlying the Development of Obesity which is focused on the role of extracellular vesicles in placenta development in obese pregnancies.
Titles
Attending Neonatologist
Hallam Hurt Professor Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Certifications
Neonatal-Perinatal Medicine – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Editorial and Academic Positions
Editorial Positions
2018-present, Biology of Reproduction, Editorial Board
Academic and Institutional Committees
2012-present, The Journal of Nutritional Biochemistry, Associate Editor
2012-present, American Journal of Physiology, Endo & Metabolism, Associate Editor
Research Interests
Neonatal hypoglycemia Intrauterine growth restriction Developmental origins of disease Dr. Simmons research program is focused on elucidating the mechanisms by which an adverse intrauterine milieu associated with intrauterine growth restriction, diabetes or obesity in pregnancy, and exposure to chemicals such as endocrine disruptors and lead (Pb) cause the later development of diseases such as obesity and diabetes. A second major area of interest is the mechanism by which placenta mal-development leads to the development of spontaneous preterm birth. This work is funded by the March of Dimes and the NIH. She is exploring the role of mitochondrial dysfunction and extracellular vesicle trafficking of mtDNA and miRNAs to the early embryo and the placenta and elucidating the epigenetic mechanisms underlying the development of adverse postnatal outcomes. As COVID-19 infection during pregnancy is associated with a higher risk of preterm birth and other adverse pregnancy outcomes, Dr. Simmons and colleagues are exploring the mechanisms underlying placenta abnormalities that have been noted in most pregnant women with COVID-19 and how placenta failure contributes to preterm birth and preeclampsia in women with COVID-19. Dr. Simmons has trained over 50 medical students, graduate students, postgraduate and clinical fellows.
Education & training
Medical Degree
MD - University of Arizona, Tucson, AZ
Internship
Northwestern University Medical School, Chicago, IL
Children's Memorial Hospital, Chicago, IL
Residency
Pediatrics - University of Arizona Medical Center, Tucson, AZ
Fellowship
Cardiovascular Research Institute, University of California, San Francisco, CA
Publications
Publications
2021
Obesity-related IL-18 Impairs Treg Function and Promotes Lung Ischemia-reperfusion Injury. Akimova T, Zhang T, Christensen LM, Wang Z, Han R, Negorev D, Samanta A, Sasson IE, Gaddapara T, Jiao J, Wang L, Bhatti TR, Levine MH, Diamond JM, Beier UH, Simmons RA, Cantu E, Wilkes DS, Lederer DJ, Anderson M, Christie JD, Hancock WW. Am J Respir Crit Care Med. 2021 Aug 4. doi: 10.1164/rccm.202012-4306OC. Online ahead of print. PMID: 34346860
Variably methylated retrotransposons are refractory to a range of environmental perturbations. Bertozzi TM, Becker JL, Blake GET, Bansal A, Nguyen DK, Fernandez-Twinn DS, Ozanne SE, Bartolomei MS, Simmons RA, Watson ED, Ferguson-Smith AC. Nat Genet. 2021 Jul 29. doi: 10.1038/s41588-021-00898-9. Online ahead of print. PMID: 34326545
Human Placental Transcriptome Reveals Critical Alterations in Inflammation and Energy Metabolism with Fetal Sex Differences in Spontaneous Preterm Birth. Lien YC, Zhang Z, Cheng Y, Polyak E, Sillers L, Falk MJ, Ischiropoulos H, Parry S, Simmons RA. Int J Mol Sci. 2021 Jul 23;22(15):7899. doi: 10.3390/ijms22157899. PMID: 34360662 Free PMC article.
Neonatal IL-4 exposure decreases adipogenesis of male rats into adulthood. Ying T, Golden TN, Cheng L, Ishibashi J, Seale P, Simmons RA. Am J Physiol Endocrinol Metab. 2021 Apr 19. doi: 10.1152/ajpendo.00600.2020. Online ahead of print. PMID: 33870712
Ying T, Simmons RA. The Role of Adipocyte Precursors in Development and Obesity. Front Endocrinol (Lausanne). 2021 Feb 19;11:613606. doi: 10.3389/fendo.2020.613606. eCollection 2020.PMID: 33679601 Free PMC article. Review.
Bhat SF, Pinney SE, Kennedy KM, McCourt CR, Mundy MA, Surette MG, Sloboda DM, Simmons RA. Exposure to high fructose corn syrup during adolescence in the mouse alters hepatic metabolism and the microbiome in a sex-specific manner. J Physiol. 2021 Jan 15. doi: 10.1113/JP280034. Online ahead of print. PMID: 33450094
2020
Lien YC, Won KJ, Simmons RA. Transcriptomic and Quantitative Proteomic Profiling Reveals Signaling Pathways Critical for Pancreatic Islet Maturation. Endocrinology. 2020 Dec 1;161(12):bqaa187. doi: 10.1210/endocr/bqaa187.PMID: 33053583
Binder RA, Alarja NA, Robie ER, Kochek KE, Xiu L, Rocha-Melogno L, Abdelgadir A, Goli SV, Farrell AS, Coleman KK, Turner AL, Lautredou CC, Lednicky JA, Lee MJ, Polage CR, Simmons RA, Deshusses MA, Anderson BD, Gray GC. Environmental and Aerosolized Severe Acute Respiratory Syndrome Coronavirus 2 Among Hospitalized Coronavirus Disease 2019 Patients. J Infect Dis. 2020 Nov 9;222(11):1798-1806. doi: 10.1093/infdis/jiaa575.PMID: 32905595 Free PMC article.
Lien YC, Zhang Z, Barila G, Green-Brown A, Elovitz MA, Simmons RA. Intrauterine Inflammation Alters the Transcriptome and Metabolome in Placenta. Front Physiol. 2020 Nov 5;11:592689. doi: 10.3389/fphys.2020.592689. eCollection 2020.PMID: 33250783 Free PMC article.
Laktabai J, Saran I, Zhou Y, Simmons RA, Turner EL, Visser T, O'Meara W. Subsidise the test, the treatment or both? Results of an individually randomised controlled trial of the management of suspected malaria fevers in the retail sector in western Kenya. BMJ Glob Health. 2020 Nov;5(11):e003378. doi: 10.1136/bmjgh-2020-003378.PMID: 33148541 Free PMC article.
Rashid CS, Bansal A, Mesaros C, Bartolomei MS, Simmons RA. Paternal bisphenol A exposure in mice impairs glucose tolerance in female offspring. Food Chem Toxicol. 2020 Nov;145:111716. doi: 10.1016/j.fct.2020.111716. Epub 2020 Sep 3.PMID: 32890688
Lien YC, Won KJ, Simmons RA. Transcriptomic and Quantitative Proteomic Profiling Reveals Signaling Pathways Critical for Pancreatic Islet Maturation. Endocrinology. 2020 Oct 15:bqaa187. doi: 10.1210/endocr/bqaa187. Online ahead of print. PMID: 33053583
Troy JD, Simmons RA. Statistical properties of Continuous Composite Outcomes: Implications for clinical trial design. Contemp Clin Trials Commun. 2020 Sep 24;20:100655. doi: 10.1016/j.conctc.2020.100655. eCollection 2020 Dec.PMID: 33024883 Free PMC article.
Golden TN, Simmons RA. Maternal and neonatal response to COVID-19. Am J Physiol Endocrinol Metab. 2020 Aug 1;319(2):E315-E319. doi: 10.1152/ajpendo.00287.2020. Epub 2020 Jun 23.PMID: 32574110 Free PMC article.
Giusto A, Green EP, Simmons RA, Ayuku D, Patel P, Puffer ES. A multiple baseline study of a brief alcohol reduction and family engagement intervention for fathers in Kenya. J Consult Clin Psychol. 2020 Aug;88(8):708-725. doi: 10.1037/ccp0000559.PMID: 32700954
Anderson BD, Yondon M, Bailey ES, Duman EK, Simmons RA, Greer AG, Gray GC. Environmental bioaerosol surveillance as an early warning system for pathogen detection in North Carolina swine farms: A pilot study. Transbound Emerg Dis. 2020 Jun 14. doi: 10.1111/tbed.13683. Online ahead of print.PMID: 32535997
Lien YC, Wang PZ, Lu XM, Simmons RA. Altered Transcription Factor Binding and Gene Bivalency in Islets of Intrauterine Growth Retarded Rats. Cells. 2020 Jun 9;9(6). pii: E1435. doi: 10.3390/cells9061435. PMID: 32527043 [PubMed - in process] Free Article. Similar articles.
Elshenawy S, Pinney SE, Stuart T, Doulias PT, Zura G, Parry S, Elovitz MA, Bennett MJ, Bansal A, Strauss JF 3rd, Ischiropoulos H, Simmons RA. The Metabolomic Signature of the Placenta in Spontaneous Preterm Birth. Int J Mol Sci. 2020 Feb 4;21(3). pii: E1043. doi: 10.3390/ijms21031043. PMID: 32033212.
2019
Russell MW, Moldenhauer JS, Rychik J, Burnham NB, Zullo E, Parry SI, Simmons RA, Elovitz MA, Nicolson SC, Linn RL, Johnson MP, Yu S, Sampson MG, Hakonarson H, Gaynor JW. Damaging Variants in Proangiogenic Genes Impair Growth in Fetuses with Cardiac Defects. J Pediatr. 2019 Jun 18. pii: S0022-3476(19)30578-5. doi: 10.1016/j.jpeds.2019.05.013. [Epub ahead of print]
Schmatz M, Srinivasan L, Grundmeier RW, Elci OU, Weiss SL, Masino AJ, Tremoglie M, Ostapenko S, Harris MC: Surviving Sepsis in a Referral Neonatal Intensive Care Unit: Association between Time to Antibiotic Administration and In-Hospital Outcomes. J. Pediatr pii: S0022-3476(19)31081-9. DOI: 10.1016/j.jpeds.2019.08.023. PMID: 31604632.
Agawu A, Fahl C, Alexis D, Diaz T, Harris D, Harris MC, Aysola J, Cronholm PF, Higginbotham EJ: The Influence of Gender and Underrepresented Minority Status on Medical Student Ranking of Residency Programs. J Natl Med Assoc. 2019 Oct 23. pii: S0027-9684(18)30414-0. doi: 10.1016/j.jnma.2019.09.002. PMID: 31668360.
2018
Xin F, Fischer E, Krapp C, Krizman EN, Lan Y, Mesaros C, Snyder NW, Bansal A, Robinson MB, Simmons RA, Bartolomei MS. Mice exposed to bisphenol A exhibit depressive-like behavior with neurotransmitter and neuroactive steroid dysfunction. Horm Behav. 2018 May 12. pii: S0018-506X(18)30023-0. doi: 10.1016/j.yhbeh.2018.05.010. [Epub ahead of print]
Jensen EA, Foglia EE, Dysart KC, Simmons RA, Aghai ZH, Cook A, Greenspan JS, DeMauro SB. Adverse effects of small for gestational age differ by gestational week among very preterm infants. Arch Dis Child Fetal Neonatal Ed. 2018 May 5. pii: fetalneonatal-2017-314171. doi: 10.1136/archdischild-2017-314171. [Epub ahead of print]
Alexander J, Teague AM, Chen J, Aston CE, Leung YK, Chernausek S, Simmons RA, Pinney SE. Offspring sex impacts DNA methylation and gene expression in placenta from women with diabetes during pregnancy. PLoS One. 2018 Feb 22;13(2):e0190698. doi: 10.1371/journal.pone.0190698. eCollection 2018.
Gaynor JW, Parry S, Moldenhauer JS, Simmons RA, Rychik J, Ittenbach RF, Russell WW, Zullo E, Ward JL, Nicolson SC, Spray TL, Johnson MP. The impact of the maternal-fetal environment on outcomes of surgery for congenital heart disease in neonates. Eur J Cardiothorac Surg. 2018 Feb 13. doi: 10.1093/ejcts/ezy015. [Epub ahead of print] PMID: 29447332 [PubMed - as supplied by publisher]
Stuart TJ, O'Neill K, Condon D, Sasson I, Sen P, Xia Y, Simmons RA. Diet-induced obesity alters the maternal metabolome and early placenta transcriptome and decreases placenta vascularity in the mouse. Biol Reprod. 2018 Jan 18. doi: 10.1093/biolre/ioy010. [Epub ahead of print] PMID: 29360948
Rashid CS, Lien YC, Bansal A, Jaeckle-Santos LJ, Li C, Won KJ, Simmons RA. Transcriptomic analysis reveals novel mechanisms mediating islet dysfunction in the intrauterine growth restricted (IUGR) rat. Endocrinology. 2018 Jan 4. doi: 10.1210/en.2017-00888. [Epub ahead of print] PMID: 29309562
2017
Gordon SM, Srinivasan L, Harris MC. Neonatal Meningitis: Overcoming Challenges in Diagnosis, Prognosis and Treatment with Omics. Front Pediatr. 5: 139, 2017. PMID: 28670576.
2014
Tran PV, Kennedy BC, Lien YC, Simmons RA, Georgieff MK. Fetal iron deficiency induces chromatin remodeling at the Bdnf locus in adult rat hippocampus. Am J Physiol Regul Integr Comp Physiol. 2014 Dec 17:ajpregu.00429.2014. doi: 10.1152/ajpregu.00429.2014. [Epub ahead of print]. Read the abstract.
2013
Simmons RA: Preclampsia and prematurity as precursors to adolescent obesity. J Pediatr 162: 889-890, 2013.
Simmons RA: Programming of DNA methylation in type 2 diabetes. Diabetologia 56: 947-948, 2013. Invited commentary.
2012
Pinney SE, Simmons R: Metabolic programming, epigenetics, and gestational diabetes mellitus. Curr Diab Rep 12: 67-74, 2012.
Simmons RA: Developmental Origins of Diabetes: The Role of Oxidative Stress. Best Pract Res Clin Endocrinol Metab 26: 701-708, 2012, NIHMS 375424.
2011
Simmons RA: Abnormalities of Fetal Growth in Avery's Diseases of the Newborn. Avery's Diseases of the Newborn. SU Devaskar, CA Gleason (eds.). WB Saunders, Philadelphia, Page: 51-59, 2011.
Simmons RA: Cell glucose transport and glucose handling during fetal and neonatal development. Fetal and Neonatal Physiology Fourth Edition. R Poin, W Fox, S Abman (eds.). Elsevier Saunders, Philadelphia, Page: 560-568, 2011.
Simmons R: Epigenetics and maternal nutrition: nature v. nurture. Proc Nutri Soc 70: 73-81, 2011.
French HM, Simmons RA: Infant of a Diabetic Mother in Rudolph's Pediatrics, 22nd edition. Rudolph's Pediatrics. C Rudolph, G Lister, A Gershon, L First, A Rudolph (eds.). McGraw-Hill, New York, 2011.
2010
Sen S, Simmons RA. Maternal Antioxidant Supplementation Prevents Adiposity in the Offspring of Western diet-fed Dams. Diabetes. Epub 2010 Sep 7. Read the abstract.