Simone S. Riedel, PhD
About Simone S. Riedel, PhD
Titles
Researcher
Research Assistant Professor of Pediatrics (Oncology), Perelman School of Medicine at the University of Pennsylvania
Awards and Honors
2019, Abstract Achievement Award, American Society of Hematology Annual Meeting
2019, Oral Presentation Award, FASEB SRC, The Hematologic Malignancies Conference
2014, 2015, Abstract Achievement Award, American Society of Hematology Annual Meeting
Leadership and Memberships
Memberships in Professional Organizations
2019-present, The American Society of Hematology
Education & training
Graduate Degree
PhD in Immunology - Wuerzburg University, Germany
MS in Biology - Kaiserslautern Technical University, Germany
Fellowship
Postdoctoral Fellow - Kathrin Bernt Lab, Center for Childhood Cancer Research, Children's Hospital of Philadelphia,Philadelphia, PA
Postdoctoral Fellow - Kathrin Bernt Lab, Department of Pediatrics, University of Colorado, Denver, CO
Publications
Publications
2022
Huijuan Lin, Keren Cheng, Hiroshi Kubota, Yemin Lan, Simone S Riedel, Kazue Kakiuchi, Kotaro Sasaki, Kathrin M Bernt, Marisa S Bartolomei, Mengcheng Luo, P Jeremy Wang: Histone methyltransferase DOT1L is essential for self-renewal of germline stem cells. Genes & Development 1(36): 752-763, Jun 2022.
2021
Carina A Bäuerlein, Musga Qureischi, Zeinab Mokhtari, Paula Tabares, Christian Brede, Ana-Laura Jordán Garrote, Simone S Riedel, Martin Chopra, Simone Reu, Anja Mottok, Estibaliz Arellano-Viera, Carolin Graf, Miriam Kurzwart, Katharina Schmiedgen, Hermann Einsele, Matthias Wölfl, Paul-Gerhardt Schlegel, Andreas Beilhack: A T-Cell Surface Marker Panel Predicts Murine Acute Graft-Versus-Host Disease. Frontiers in immunology 11(5): 593321, Jan 2021.
Clara Libbrecht, Hongbo M Xie, Molly C Kingsley, Jessica N Haladyna, Simone S Riedel, Fatemeh Alikarami, Alexandra Lenard, Gerard M McGeehan, Patricia Ernst, Kathrin M Bernt: Menin is necessary for long term maintenance of meningioma-1 driven leukemia. Leukemia 35(5): 1405-17, May 2021.
Simone S Riedel, Congcong Lu, Hongbo M Xie, Kevin Nestler, Marit W Vermunt, Alexandra Lenard, Laura Bennett, Nancy A Speck, Ichiro Hanamura, Julie A Lessard, Gerd A Blobel, Benjamin A Garcia, Kathrin M Bernt: Intrinsically disordered Meningioma-1 stabilizes the BAF complex to cause AML. Molecular cell 81(11): 2332-48, Jun 2021.
Pamela J. Sung, Simone Sidoli, Simone S. Riedel, Katarzyna Kulej, Hongbo Xie, Bryan Manning, Daniel Tsai, Gerald Wertheim, Benjamin A. Garcia, Sara E. Meyer, Kathrin M. Bernt, Martin P. Carroll: FLT3 Inhibition Downregulates EZH2 in AML and Promotes Myeloid Differentiation. Blood 138(1): 785, 2021.
2020
Alexandra Lenard, Hongbo Michael Xie, Taylor Pastuer, Tyler Shank, Clara Libbrecht, Molly Kingsley, Simone S Riedel, Zuo-Fei Yuan, Nan Zhu, Tobias Neff, Kathrin M Bernt: Epigenetic regulation of protein translation in KMT2A-rearranged AML. Experimental hematology 85(1): 57-69, May 2020.
Molly C Kingsley, Hongbo M Xie, Bo-Rui Chen, Simone S Riedel, Taylor Pastuer, Madelyn K Bollig, Tyler Shank, Clara Libbrecht, Sally P Stabler, Aniruddha J Deshpande, Andrew M Intlekofer, Kathrin M Bernt: Specific patterns of H3K79 methylation influence genetic interaction of oncogenes in AML. Blood advances 4(13): 3109-22, Jul 2020.
2016
Sebastian Dietl, Stefanie Schwinn, Susanne Dietl, Simone Riedel, Frank Deinlein, Stefan Rutkowski, Andre O von Bueren, Jürgen Krauss, Tilmann Schweitzer, Giles H Vince, Daniel Picard, Matthias Eyrich , Andreas Rosenwald, Vijay Ramaswamy, Michael D Taylor, Marc Remke, Camelia M Monoranu, Andreas Beilhack, Paul G Schlegel, Matthias Wölfl: MB3W1 is an orthotopic xenograft model for anaplastic medulloblastoma displaying cancer stem cell-and Group 3-properties. BMC cancer 16(1): 1-13, Feb 2016.
Etienne Danis, Taylor Yamauchi, Kristen Echanique, Xi Zhang, Jessica N Haladyna, Simone S Riedel, Nan Zhu, Huafeng Xie, Stuart H Orkin, Scott A Armstrong, Kathrin M Bernt, Tobias Neff: Ezh2 controls an early hematopoietic program and growth and survival signaling in early T cell precursor acute lymphoblastic leukemia. Cell reports 14(8): 1953-65, Mar 2016.
Simone S Riedel, Jessica N Haladyna, Matthew Bezzant, Brett Stevens, Daniel A Pollyea, Amit U Sinha, Scott A Armstrong, Qi Wei, Roy M Pollock, Scott R Daigle, Craig T Jordan, Patricia Ernst, Tobias Neff, Kathrin M Bernt: MLL1 and DOT1L cooperate with meningioma-1 to induce acute myeloid leukemia. The Journal of clinical investigation 126(4): 1438-50, Apr 2016.
Haladyna JN, Pastuer T, Riedel SS, Perraud A-L, Bernt KM: Transient potential receptor melastatin-2 (Trpm2) does not influence murine MLL-AF9-driven AML leukemogenesis or in vitro response to chemotherapy. Experimental hematology 44(7): 596-602, Jul 2016.
2015
Etienne Danis, Taylor Yamauchi, Kristen Echanique, Jessica Haladyna, Roshni Kalkur, Simone Riedel, Nan Zhu, Huafeng Xie, Kathrin M Bernt, Stuart H Orkin, Scott A Armstrong, Tobias Neff: Inactivation of Eed impedes MLL-AF9-mediated leukemogenesis through Cdkn2a-dependent and Cdkn2aindependent mechanisms in a murine model. Experimental hematology 43(11): 930-5, Nov 2015.
2014
Johannes Trebing, Isabell Lang, Martin Chopra, Steffen Salzmann, Mahan Moshir, Karen Silence, Simone S Riedel, Daniela Siegmund, Andreas Beilhack, Christoph Otto, Harald Wajant: A novel llama antibody targeting Fn14 exhibits anti-metastatic activity in vivo. MAbs 6(1): 297-308, Jan 2014.
2013
Tanja Heimberger, Mindaugas Andrulis, Simone Riedel, Thorsten Stühmer, Heike Schraud, Andreas Beilhack, Thomas Bumm, Bjarne Bogen, Hermann Einsele, Ralf C Bargou, Manik Chatterjee: The heat shock transcription factor 1 as a potential new therapeutic target in multiple myeloma. British Journal of Haematology. 160(4): 465-76, Feb 2013.
Carina A Bäuerlein, Simone S Riedel, Jeanette Baker, Christian Brede, Ana-Laura Jordán Garrote, Martin Chopra, Miriam Ritz, Georg F Beilhack, Stephan Schulz, Robert Zeiser, Paul G Schlegel, Hermann Einsele, Robert S Negrin, Andreas Beilhack: A diagnostic window for the treatment of acute graft-versus-host disease prior to visible clinical symptoms in a murine model. BMC medicine 11(1): 1-9, May 2013.
Martin Chopra, Simone S Riedel, Marlene Biehl, Stefanie Krieger, Viktoria von Krosigk, Carina A Bäuerlein, Christian Brede, Ana-Laura Jordan Garrote, Sabrina Kraus, Viktoria Schäfer, Miriam Ritz, Katharina Mattenheimer, Axelle Degla, Anja Mottok, Hermann Einsele, Harald Wajant, Andreas Beilhack: Tumor necrosis factor receptor 2-dependent homeostasis of regulatory T cells as a player in TNF-induced experimental metastasis. Carcinogenesis 34(6): 1296-303, Jun 2013.
Andreas Thalheimer, Doreen Korb, Lars Bönicke, Armin Wiegering, Bettina Mühling, Manuela Schneider, Silvia Koch, Simone S Riedel, Christoph Thomas Germer, Andreas Beilhack, Stephanie Brändlein, Christoph Otto: Noninvasive visualization of tumor growth in a human colorectal liver metastases xenograft model using bioluminescence in vivo imaging. journal of surgical research. Journal of Surgical Research 185(1): 143-51, Nov 2013.
2012
Christian Brede, Mike Friedrich, Ana-Laura Jordán-Garrote, Simone S Riedel, Carina A Bäuerlein, Katrin G Heinze, Tobias Bopp, Stephan Schulz, Anja Mottok, Carolin Kiesel, Katharina Mattenheimer, Miriam Ritz, Viktoria von Krosigk, Andreas Rosenwald, Hermann Einsele, Robert S Negrin, Gregory S Harms, Andreas Beilhack: Mapping immune processes in intact tissues at cellular resolution. The Journal of Clinical Investigation 122(12): 4439-46, Dec 2012.
Simone S Riedel, Anja Mottok, Christian Brede, Carina A Bäuerlein, Ana-Laura Jordán Garrote, Miriam Ritz, Katharina Mattenheimer, Andreas Rosenwald, Hermann Einsele, Bjarne Bogen, Andreas Beilhack: Non-invasive imaging provides spatiotemporal information on disease progression and response to therapy in a murine model of multiple myeloma. PloS one 7(12): e52398, 2012.