Karen M. Puopolo, MD, PhD
Areas of expertise: Neonatal-perinatal medicine
Locations: Main Building, CHOP at Penn Medicine Pennsylvania Hospital
About Karen M. Puopolo, MD, PhD
Titles
Attending Neonatologist
Section Chief for Newborn Medicine, Pennsylvania Hospital
Professor of Pediatrics, Perelman School of Medicine at the University of Pennsylvania
Certifications
Neonatal-Perinatal Medicine – American Board of Pediatrics
Pediatrics – American Board of Pediatrics
Awards and Honors
2023, Eastern Society for Pediatric Research Mentor of the Year
2022, Pennsylvania Pediatrician of the Year Award from the American Academy of Pediatrics (AAP)
2021, Schmidt-Kirpalani Mentoring Award
Leadership and Memberships
Memberships in Professional Organizations
1993-present, American Academy of Pediatrics
2006-present, Society for Pediatric Research
2014-2021, American Academy of Pediatrics Committee on Fetus and Newborn
2016-present, American Pediatric Society
2000-present, Pediatric Infectious Diseases Society
Editorial and Academic Positions
Editorial positions
2013-2019, Editorial Board, NeoReviews
2020-2023, Editorial Board, Pediatrics
2023-present, Associate Editor, Pediatrics
2023-present, Section Editor, UpToDate
2020-present, Pediatrics, Editorial Board Member
Education & training
Graduate Degree
PhD in Medicine and Cellular and Molecular Physiology - Tufts University School of Medicine, Boston, MA (Alpha Omega Alpha)
Medical Degree
MD - Tufts University School of Medicine, Boston, MA (Alpha Omega Alpha)
Residency
Pediatrics - Boston Children's Hospital, Boston, MA
Fellowship
Neonatal-Perinatal Medicine - Boston Children's Hospital, Boston, MA
Neonatal-Perinatal Medicine (Research) - The Channing Division of Network Medicine, Brigham and Women’s Hospital, Boston, MA
Publications
Publications
2024
Puopolo KM. Postnatally acquired cytomegalovirus infection among preterm infants. Curr Opin Infect Dis. 2024 Oct 1;37(5):425-430. doi: 10.1097/QCO.0000000000001047. Epub 2024 Jul 31. PMID: 39105629.
Flannery DD, Zevallos Barboza A, Mukhopadhyay S, Gerber JS, McDonough M, Shu D, Hennessy S, Wade KC, Puopolo KM. Antibiotic use among extremely low birth- weight infants from 2009 to 2021: a retrospective observational study. Arch Dis Child Fetal Neonatal Ed. 2024 Jul 20:fetalneonatal-2023-326734. doi: 10.1136/archdischild-2023-326734. Epub ahead of print. PMID: 39033026.
Puopolo KM. Hospital-Onset Bacteremia-Counting Them All. JAMA Pediatr. 2024 Aug 1;178(8):750-752. doi: 10.1001/jamapediatrics.2024.2156. PMID: 39008315.
Flannery DD, Shah NC, Puopolo KM. Perinatal COVID-19: Implications for care of the newborn. Semin Perinatol. 2024 Jun;48(4):151921. doi: 10.1016/j.semperi.2024.151921. Epub 2024 Jun 6. PMID: 38871489.
Gottschalk A, Coggins S, Dhudasia MB, Flannery DD, Healy T, Puopolo KM, Gerber J, Mukhopadhyay S. Utility of Anaerobic Blood Cultures in Neonatal Sepsis Evaluation. J Pediatric Infect Dis Soc. 2024 Aug 24;13(8):406-412. doi: 10.1093/jpids/piae056. PMID: 38822536.
Walter J, Hill DL, Cetin A, DeWitt A, Kellom K, Quarshie W, Griffis H, Shults J, Arnold R, Tjia J, Puopolo K, Curley MAQ, Feudtner C. A Pediatric Interprofessional Cardiac Intensive Care Unit Intervention: CICU Teams and Loved Ones Communicating (CICU TALC) is Feasible, Acceptable, and Improves Clinician Communication Behaviors in Family Meetings. Pediatr Cardiol. 2024 May 3. doi: 10.1007/s00246-024-03497-7. Epub ahead of print. PMID: 38700711.
Shukla VV, Carper BA, Ambalavanan N, Rysavy MA, Bell EF, Das A, Patel RM, D'Angio CT, Watterberg KL, Cotten CM, Merhar SL, Wyckoff MH, Sánchez PJ, Kumbhat N, Carlo WA; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Social distancing and extremely preterm births in the initial COVID-19 pandemic period. J Perinatol. 2024 Jul;44(7):1050-1057. doi: 10.1038/s41372-024-01898-3. Epub 2024 Feb 22. PMID: 38388715; PMCID: PMC11226398.
Coggins SA, Puopolo KM. Neonatal Group B Streptococcus Disease. Pediatr Rev. 2024 Feb 1;45(2):63-73. doi: 10.1542/pir.2023-006154. PMID: 38296778; PMCID: PMC10919294.
van der Weijden BM, Janssen SWCM, Benitz WE, Kuzniewicz MW, Puopolo KM, Plötz FB, Achten NB. Open-source code to extend early-onset sepsis calculator accessibility. Lancet Digit Health. 2024 Mar;6(3):e153. doi: 10.1016/S2589-7500(23)00253-4. Epub 2024 Jan 22. Erratum in: Lancet Digit Health. 2024 Mar;6(3):e156. doi: 10.1016/S2589-7500(24)00029-3. PMID: 38262801.
2023
Flannery DD, Puopolo KM. EBNEO Commentary: Safety and immunogenicity of GBS vaccine in pregnancy and determination of a serocorrelate for infant protection. Acta Paediatr. 2024 Jan;113(1):157-158. doi: 10.1111/apa.17038. Epub 2023 Nov 10. PMID: 37950357.
Flannery DD, Zevallos Barboza A, Mukhopadhyay S, Wade KC, Gerber JS, Shu D, Puopolo KM. Antibiotic Use Among Infants Admitted to Neonatal Intensive Care Units. JAMA Pediatr. 2023 Dec 1;177(12):1354-1356. doi: 10.1001/jamapediatrics.2023.3664. PMID: 37812442; PMCID: PMC10562984.
Coggins SA, Mukhopadhyay S, Triebwasser J, Downes KJ, Christie JD, Puopolo KM. Association of delivery risk phenotype with early-onset sepsis in preterm infants. J Perinatol. 2023 Sep;43(9):1166-1172. doi: 10.1038/s41372-023-01743-z. Epub 2023 Aug 5. PMID: 37543652; PMCID: PMC10530160.
Coggins SA, Willis Z, Benjamin DK, Mukhopadhyay S, Laughon M, Greenberg RG, Clark RH, Puopolo KM. Early antibiotic exposure in very-low birth weight infants and infection risk at 3-7 days after birth. J Perinatol. 2023 Sep;43(9):1158-1165. doi: 10.1038/s41372-023-01737-x. Epub 2023 Jul 25. PMID: 37491474; PMCID: PMC10529484.
Young LW, Ounpraseuth ST, Merhar SL, Hu Z, Simon AE, Bremer AA, Lee JY, Das A, Crawford MM, Greenberg RG, Smith PB, Poindexter BB, Higgins RD, Walsh MC, Rice W, Paul DA, Maxwell JR, Telang S, Fung CM, Wright T, Reynolds AM, Hahn DW, Ross J, McAllister JM, Crowley M, Shaikh SK, Puopolo KM, Christ L, Brown J, Riccio J, Wong Ramsey K, Akshatha, Braswell EF, Tucker L, McAlmon KR, Dummula K, Weiner J, White JR, Howell MP, Newman S, Snowden JN, Devlin LA; ACT NOW Collaborative. Eat, Sleep, Console Approach or Usual Care for Neonatal Opioid Withdrawal. N Engl J Med. 2023 Jun 22;388(25):2326-2337. doi: 10.1056/NEJMoa2214470. Epub 2023 Apr 30. PMID: 37125831; PMCID: PMC10433732.
Sidell MA, Getahun D, Tartof SY, Xiang AH, Sharma AJ, Mukhopadhyay S, Puopolo KM, Schrag SJ, Kunani P, Koebnick C. Higher body mass index after intrapartum antibiotic exposure in children persists over 10-years. Pediatr Obes. 2023 Jul;18(7):e13035. doi: 10.1111/ijpo.13035. Epub 2023 Apr 7. PMID: 37026509; PMCID: PMC11299422.
Hudak ML, Flannery DD, Barnette K, Getzlaff T, Gautam S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Ellington SR, Galang RR, Snead MC, Woodworth KR, Zapata LB, Puopolo KM; AMERICAN ACADEMY OF PEDIATRICS NPC-19 REGISTRY INVESTIGATORS. Maternal and Newborn Hospital Outcomes of Perinatal SARS-CoV-2 Infection: A National Registry. Pediatrics. 2023 Feb 1;151(2):e2022059595. doi: 10.1542/peds.2022-059595. PMID: 36995183; PMCID: PMC11292484.
Flannery DD, Zevallos Barboza A, Wade KC, Pfeifer MR, Gerber JS, Morris JS, Puopolo KM. Measles Serostatus Among Parturient Patients at 2 Philadelphia Hospitals in 2021. JAMA. 2023 Feb 28;329(8):682-684. doi: 10.1001/jama.2023.0166. PMID: 36735270; PMCID: PMC9975922.
Coggins SA, Edwards EM, Flannery DD, Gerber JS, Horbar JD, Puopolo KM. Serratia Infection Epidemiology Among Very Preterm Infants in the Neonatal Intensive Care Unit. Pediatr Infect Dis J. 2023 Feb 1;42(2):152-158. doi: 10.1097/INF.0000000000003736. Epub 2022 Nov 2. PMID: 36638403; PMCID: PMC9846441.
2022
Flannery, D.D., Zevallos Barboza, A., Pfeifer, M.R. et al. Perinatal COVID-19 maternal and neonatal outcomes at two academic birth hospitals. J Perinatol (2022). https://doi.org/10.1038/s41372-022-01446-x
Flannery DD, Puopolo KM, Hansen NI, Gerber JS, Sánchez PJ, Stoll BJ, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Antimicrobial Susceptibility Profiles Among Neonatal Early-Onset Sepsis Pathogens. Pediatr Infect Dis J. March 2022 Mar; 41(3):263-271/ PMID: 34862339; PubMed Central PMCID: PMC8831448
Flannery DD, Mukhopadhyay S, Morales KH, Dhudasia MB, Passarella M, Gerber JS, Puopolo KM. Delivery Characteristics and the Risk of Early-Onset Neonatal Sepsis. Pediatrics. 2022;149(2):e2021052900. PubMed PMID: 35022750; PubMed Central PMCID: pending doi: 10.1542/peds.2021-052900. Online ahead of print.
Flannery DD, Chiotos K, Gerber JS, Puopolo KM. Neonatal multidrug resistant gram-negative infection: epidemiology, mechanisms of resistance, and management. Pediatr Res. 2022; 91(2):380-391. PubMed PMID: 34599280; PubMed Central PMCID: PMC8819496
Flannery DD, Passarella M, Mukhopadhyay S, Dhudasia MB, Gerber JS, Lorch SA, Hennessy S, Puopolo KM. Early Childhood Antibiotic Utilization for Infants Discharged from the Neonatal Intensive Care Unit. J Perinatol. 2022. In press.
O'Leary EN, Edwards JR, Srinivasan A, Neuhauser MM, Soe MM, Webb AK, Edwards EM, Horbar JD, Soll RF, Roberts J, Hicks LA, Wu H, Zayack D, Braun D, Cali S, Edwards WH, Flannery DD, Fleming-Dutra KE, Guzman-Cottrill JA, Kuzniewicz M, Lee GM, Newland J, Olson J, Puopolo KM, Rogers SP, Schulman J, Septimus E, Pollock DA. National Healthcare Safety Network 2018 Baseline Neonatal Standardized Antimicrobial Administration Ratios. Hosp Pediatr. 2022 Feb 1;12(2):190-198. doi: 10.1542/hpeds.2021-006253. PubMed PMID: 35075483; PubMed Central PMCID: pending
Mukhopadhyay S, Briker SM, Flannery DD, Dhudasia MB, Coggins SA, Woodford E, Walsh EM. Li S, Puopolo KM, Kuzniewicz MW. Time to Positivity of Blood Cultures in Neonatal Late-Onset Bacteremia. Arch Dis Child – Fetal Neonat Ed. Published Online First: 10 March 2022. doi: 10.1136/archdischild-2021-323416
Flannery DD, Zevallos Barboza A, Pfeifer MR, Hudak ML, Barnette K, Getzlaff TR, Ellington SR, Woodworth KR, Dhudasia MB, Mukhopadhyay S, Weinberg DD, Foglia EE, Puopolo KM. Perinatal COVID-19 maternal and neonatal outcomes at two academic birth hospitals. J Perinatol. 2022 Oct;42(10):1338-1345. doi: 10.1038/s41372-022-01446-x. Epub 2022 Jul 1. PMID: 35778485; PMCID: PMC9247898.
Triebwasser JE, Dhudasia MB, Mukhopadhyay S, Flannery DD, Gouma S, Hensley SE, Puopolo KM. Assessment of SARS-CoV-2 serostatus and hypertensive disorders of pregnancy. Am J Obstet Gynecol. 2022 Oct;227(4):664-666.e1. doi: 10.1016/j.ajog.2022.06.012. PubMed PMID: 35718110; PubMed Central PMCID: PMC9212257
Flannery DD, Puopolo KM. The imperfect science of neonatal sepsis. Pediatr Res. Pediatr Res. 2022 Mar;91(4):733-734. doi: 10.1038/s41390-021-01863-2. Epub 2021 Nov 20. PubMed PMID: 34802037
Flannery DD, Puopolo KM, Hansen NI, Sánchez PJ, Stoll BJ; Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Neonatal infections: Insights from a multicenter longitudinal research collaborative. Semin Perinatol. 2022 Nov;46(7):151637. doi: 10.1016/j.semperi.2022.151637. Epub 2022 Jun 10. PubMed PMID: 35864010
Flannery DD, Puopolo KM. Neonatal Early-Onset Sepsis. Neoreviews, American Academy of Pediatrics. 2022 Nov 1;23(11):756-770. doi: 10.1542/neo.23-10-e756. PubMed PMID: 36316253
Flannery DD, Edwards EM, Coggins SA, Horbar JD, Puopolo KM. Late-onset sepsis among very preterm infants. Pediatrics. 2022. doi: 10.1542/peds.2022-058813.
Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Briker SM, Triebwasser JE, Gerber JS, Morris JS, Weirick ME, McAllister CM, Hensley SE, Puopolo KM. Comparison of Maternal and Neonatal Antibody Levels After COVID-19 Vaccination vs SARS-CoV-2 Infection. JAMA Netw Open. 2022;5(11):e2240993. PubMed PMID: 36350652.
Flannery DD, Edwards EM, Coggins SA, Horbar JD, Puopolo KM. Late-Onset Sepsis Among Very Preterm Infants. Pediatrics. 2022;150(6):e2022058813. PubMed PMID: 36366916.
Burris HH, Mullin AM, Dhudasia MB, Flannery DD, Mukhopadhyay S, Pfeifer MR, Woodford EC, Briker SM, Triebwasser JE, Morris JS, Montoya-Williams D, Gouma S, Hensley SE, Puopolo KM. Neighborhood Characteristics and Racial Disparities in Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Seropositivity in Pregnancy. Obstet Gynecol. 2022. In press.
Puopolo KM, Mukhopadhyay S, Hansen NI, Flannery DD, Greenberg RG, Sanchez PJ, Bell EF, DeMauro SB, Wyckoff MH, Eichenwald EC, Stoll BJ, for the Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. Group B Streptococcal Infection in Extremely Preterm Neonates and Neurodevelopmental Outcomes at 2 Years. Clin Infect Dis. March 2022. PubMed PMID: pending; PubMed Central PMCID: pending. doi:10.1093/CID/CIAC222. Online ahead of print.
2021
Flannery DD, Edwards EM, Puopolo KM, Horbar JH. Early-Onset Sepsis Among Very Preterm Infants. Pediatrics. 2021 Oct;148(4):e2021052456. PubMed PMID: 34493539; PubMed Central PMCID: pending
Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Triebwasser JE, Gerber JS, Morris JS, Weirick ME, McAllister CM, Bolton MJ, Arevalo CP, Anderson EM, Goodwin EC, Hensley SE, Puopolo KM. Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatr. 2021 Jun 1;175(6):594-600. PubMed PMID: 33512440; PubMed Central PMCID: PMC7846944.
Flannery DD, Akinboyo IC, Mukhopadhyay S, Tribble AC, Song L, Chen F, Li Y, Gerber JS, Puopolo, KM. Antibiotic Susceptibility of Escherichia coli Among Infants Admitted to Neonatal Intensive Care Units Across the US from 2009 to 2017. JAMA Pediatr. 2021 Feb 1;175(2):168-175. PubMed PMID: 33165599; PubMed Central PMCID: PMC7653538.
Flannery DD, Puopolo KM. The imperfect science of neonatal sepsis. Pediatr Res. 2021 Nov 20. PubMed PMID: 34802037; doi: 10.1038/s41390-021-01863-2. Online ahead of print.
Flannery DD, Puopolo KM. Perinatal COVID-19: guideline development, implementation, and challenges. Curr Opin Pediatr. 2021 Apr 1;33(2):188-194. PubMed PMID: 33534424. PMCID: PMC8048376
Dhudasia MD, Flannery DD, Pfeifer MR, Puopolo KM. Updated Guidance: Prevention and Management of Perinatal Group B Streptococcus Infection. American Academy of Pediatrics NeoReviews 2021 Mar;22(3):e177-e188. PubMed PMID: 33649090.
Garber SJ, Dhudasia MB, Flannery DD, Passarella MR, Puopolo KM, Mukhopadhyay S. Delivery-based criteria for empiric antibiotic administration among preterm infants. J Perinatol. 2021 Feb;41(2):255-262. PubMed PMID: 32792629; PubMed Central PMCID: PMC7881045.
Mukhopadhyay S, Bryan M, Dhudasia MB, Quarshie W, Gerber JS, Grundmeier RW, Koebnick C, Sidell MA, Getahun D, Sharma AJ, Spiller MW, Schrag SJ, Puopolo KM. Intrapartum group B Streptococcal prophylaxis and childhood weight gain. Arch Dis Child Fetal Neonatal Ed. 2021 May 6:fetalneonatal-2020-320638. doi: 10.1136/archdischild-2020-320638. Epub ahead of print. PMID: 33958387.
Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Triebwasser JE, Gerber JS, Morris JS, Weirick ME, McAllister CM, Bolton MJ, Arevalo CP, Anderson EM, Goodwin EC, Hensley SE, Puopolo KM. Assessment of Maternal and Neonatal Cord Blood SARS-CoV-2 Antibodies and Placental Transfer Ratios. JAMA Pediatr. 2021 Jan 29:e210038. doi: 10.1001/jamapediatrics.2021.0038. Epub ahead of print. PMID: 33512440; PMCID: PMC7846944.
Mukhopadhyay S, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, Cotten CM, Sanchez PJ, Bell EF, Eichenwald EC, Stoll BJ; NICHD Neonatal Research Network. Neurodevelopmental outcomes following neonatal late-onset sepsis and blood culture-negative conditions. Arch Dis Child Fetal Neonatal Ed. 2021 Jan 21:fetalneonatal-2020-320664. doi: 10.1136/archdischild-2020-320664. Epub ahead of print. PMID: 33478957.
Koebnick C, Sidell MA, Getahun D, Tartof SY, Rozema E, Taylor B, Xiang AH, Spiller MW, Sharma AJ, Mukhopadhyay S, Puopolo KM, Schrag SJ. Intrapartum Antibiotic Exposure and Body Mass Index in Children. Clin Infect Dis. 2021 Jan 25:ciab053. doi: 10.1093/cid/ciab053. Epub ahead of print. PMID: 33493270.
2020
Kuzniewicz MW, Puopolo KM. Antibiotic stewardship for early-onset sepsis. Semin Perinatol. 2020 Dec;44(8):151325. doi: 10.1016/j.semperi.2020.151325. Epub 2020 Oct 12.PMID: 33221072
Coffin SE, Abanyie F, Bryant K, Cantey J, Fiore A, Fritz S, Guzman-Cottrill J, Hersh AL, Huskins WC, Kociolek LK, Kronman M, Lautenbach E, Lee G, Linam M, Logan LK, Milstone A, Newland J, Nyquist AC, Palazzi DL, Patel S, Puopolo K, Reddy SC, Saiman L, Sandora T, Shane AL, Smith M, Tamma PD, Zaoutis T, Zerr D, Gerber JS; Pediatric research priorities in healthcare-associated infections and antimicrobial stewardship. CDC Prevention Epicenters Program.Infect Control Hosp Epidemiol. 2020 Nov 26:1-4. doi: 10.1017/ice.2020.1267. Online ahead of print.PMID: 33239122
Patrick SW, Barfield WD, Poindexter BB; Neonatal Opioid Withdrawal Syndrome. COMMITTEE ON FETUS AND NEWBORN, COMMITTEE ON SUBSTANCE USE AND PREVENTION.Pediatrics. 2020 Nov;146(5):e2020029074. doi: 10.1542/peds.2020-029074.PMID: 33106341 Review.
Hand IL, Shellhaas RA, Milla SS; Routine Neuroimaging of the Preterm Brain. COMMITTEE ON FETUS AND NEWBORN, SECTION ON NEUROLOGY, SECTION ON RADIOLOGY.Pediatrics. 2020 Nov;146(5):e2020029082. doi: 10.1542/peds.2020-029082.PMID: 33106343
Mukhopadhyay S, Wade KC, Dhudasia MB, Skerritt L, Chou JH, Dukhovny D, Puopolo KM. Clinical impact of neonatal hypoglycemia screening in the well-baby care. J Perinatol. 2020 Sep;40(9):1331-1338. doi: 10.1038/s41372-020-0641-1. Epub 2020 Mar 9.PMID: 32152490 Free PMC article.
Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Gerber JS, Arevalo CP, Bolton MJ, Weirick ME, Goodwin EC, Anderson EM, Greenplate AR, Kim J, Han N, Pattekar A, Dougherty J, Kuthuru O, Mathew D, Baxter AE, Vella LA, Weaver J, Verma A, Leite R, Morris JS, Rader DJ, Elovitz MA, Wherry EJ, Puopolo KM, Hensley SE. SARS-CoV-2 seroprevalence among parturient women in Philadelphia. Sci Immunol. 2020 Jul 29;5(49):eabd5709. doi: 10.1126/sciimmunol.abd5709.PMID: 32727884 Free PMC article.
Flannery DD, Gouma S, Dhudasia MB, Mukhopadhyay S, Pfeifer MR, Woodford EC, Gerber JS, Arevalo CP, Bolton MJ, Weirick ME, Goodwin EC, Anderson EM, Greenplate AR, Kim J, Han N, Pattekar A, Dougherty J, Kuthuru O, Mathew D, Baxter AE, Vella LA, Weaver J, Verma A, Leite R, Morris JS, Rader DJ, Elovitz MA, Wherry EJ, Puopolo KM, Hensley SE. SARS-CoV-2 Seroprevalence Among Parturient Women. medRxiv. 2020 Jul 10:2020.07.08.20149179. doi: 10.1101/2020.07.08.20149179. Preprint.PMID: 32676623 Free PMC article. Updated.
Stoll BJ, Puopolo KM, Hansen NI, Sánchez PJ, Bell EF, Carlo WA, Cotten CM, D'Angio CT, Kazzi SNJ, Poindexter BB, Van Meurs KP, Hale EC, Collins MV, Das A, Baker CJ, Wyckoff MH, Yoder BA, Watterberg KL, Walsh MC, Devaskar U, Laptook AR, Sokol GM, Schrag SJ, Higgins RD; Early-Onset Neonatal Sepsis 2015 to 2017, the Rise of Escherichia coli, and the Need for Novel Prevention Strategies. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. JAMA Pediatr. 2020 Jul 1;174(7):e200593. doi: 10.1001/jamapediatrics.2020.0593. Epub 2020 Jul 6.PMID: 32364598
Kuzniewicz MW, Mukhopadhyay S, Li S, Walsh EM, Puopolo KM. Time to Positivity of Neonatal Blood Cultures for Early-onset Sepsis. Pediatr Infect Dis J. 2020 Jul;39(7):634-640. doi: 10.1097/INF.0000000000002632.PMID: 32379197
Fitzgerald MP, Massey SL, Fung FW, Puopolo KM, Posencheg M, Allen-Napoli L, Malcolm M, Abend NS. Expanding Access to Continuous EEG Monitoring in Neonatal Intensive Care Units. J Clin Neurophysiol. 2020 Jun 9. doi: 10.1097/WNP.0000000000000730. Online ahead of print.PMID: 32541608
Mukhopadhyay S, Puopolo KM, Hansen NI, Lorch SA, DeMauro SB, Greenberg RG, Cotten CM, Sánchez PJ, Bell EF, Eichenwald EC, Stoll BJ; Impact of Early-Onset Sepsis and Antibiotic Use on Death or Survival with Neurodevelopmental Impairment at 2 Years of Age among Extremely Preterm Infants. Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network. J Pediatr. 2020 Jun;221:39-46.e5. doi: 10.1016/j.jpeds.2020.02.038. PMID: 32446491 [PubMed - in process]
Wang KS, Cummings J, Stark A, Houck C, Oldham K, Grant C, Fallat M; Optimizing Resources in Children's Surgical Care: An Update on the American College of Surgeons' Verification Program. SECTION ON SURGERY, COMMITTEE ON FETUS AND NEWBORN, SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE.Pediatrics. 2020 May;145(5):e20200708. doi: 10.1542/peds.2020-0708. Epub 2020 Apr 20.PMID: 32312909
Wang KS, Cummings J, Stark A, Houck C, Oldham K, Grant C, Fallat M; Optimizing Resources in Children's Surgical Care: An Update on the American College of Surgeons' Verification Program. SECTION ON SURGERY, COMMITTEE ON FETUS AND NEWBORN, SECTION ON ANESTHESIOLOGY AND PAIN MEDICINE.Pediatrics. 2020 May;145(5):e20200708. doi: 10.1542/peds.2020-0708. Epub 2020 Apr 20.PMID: 32312909
Watterberg K; Providing Care for Infants Born at Home. COMMITTEE ON FETUS AND NEWBORN.Pediatrics. 2020 May;145(5):e20200626. doi: 10.1542/peds.2020-0626. Epub 2020 Apr 20.PMID: 32312908 Review.
Flannery DD, Mukhopadhyay S, Jensen EA, Gerber JS, Passarella MR, Dysart K, Aghai ZH, Greenspan J, Puopolo KM. Influence of Patient Characteristics on Antibiotic Use Rates Among Preterm Infants. J Pediatric Infect Dis Soc. 2020 Mar 14. pii: piaa022. doi: 10.1093/jpids/piaa022. [Epub ahead of print]. PMID: 32170951
2019
Puopolo KM, Lynfield R, Cummings JJ; COMMITTEE ON FETUS AND NEWBORN; COMMITTEE ON INFECTIOUS DISEASES. Management of Infants at Risk for Group B Streptococcal Disease. Pediatrics. 2019 Jul 8. pii: e20191881. doi: 10.1542/peds.2019-1881. [Epub ahead of print]
Shankaran S, Bell EF, Laptook AR, Saha S, Newman NS, Puopolo KM, Eunice Kennedy Shriver National Institute of Child Health, and Human Development Neonatal Research Network, et al. Weaning of Moderately Preterm Infants from the Incubator to the Crib: A Randomized Clinical Trial. J Pediatr. 2019 Jan;204:96-102.e4. doi: 10.1016/j.jpeds.2018.08.079. PMID: 30337189.
Greenberg RG, Chowdhury D, Hansen NI, Smith PB, Stoll BJ, Puopolo KM, Eunice Kennedy Shriver National Institute of Child Health and Human Development Neonatal Research Network, et al. Prolonged duration of early antibiotic therapy in extremely premature infants. Pediatr Res. 2019 Jan 22. doi: 10.1038/s41390-019-0300-4. [Epub ahead of print]. PMID: 30737489.
Mukhopadhyay S, Puopolo KM. Preventing Neonatal Group B Streptococcus Disease: The Limits of Success. JAMA Pediatr. 2019 Jan 14. doi: 10.1001/jamapediatrics.2018.4824. [Epub ahead of print]
PMID: 30640370
2018
Flannery DD, Ross RK, Mukhopadhyay S, Tribble AC, Puopolo KM, Gerber JS. Temporal Trends and Center Variation in Early Antibiotic Use Among Premature Infants. JAMA Network Open. 2018;1(1):e180164.
Flannery DD, Puopolo KM. Neonatal Antibiotic Use: How Much is Too Much? Pediatrics. 2018; 142(3):e20181942
Flannery DD, Puopolo KM. Neonatal Antibiotic Use: What Are We Doing and Where Shall We Go? Neoreviews, American Academy of Pediatrics. 2018;19(9):e516-525
Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≥35 0/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6). pii: e20182894. doi: 10.1542/peds.2018-2894. PMID: 30455342
Puopolo KM, Benitz WE, Zaoutis TE; Committee on Fetus and Newborn; Committee on Infectious Diseases. Management of Neonates Born at ≤34 6/7 Weeks' Gestation With Suspected or Proven Early-Onset Bacterial Sepsis. Pediatrics. 2018 Dec;142(6). pii: e20182896. doi: 10.1542/peds.2018-2896. PMID: 30455344
Mukhopadhyay S, Sengupta S, Puopolo KM. Challenges and opportunities for antibiotic stewardship among preterm infants. Arch Dis Child Fetal Neonatal Ed. 2018 Nov 13. pii: fetalneonatal-2018-315412. doi: 10.1136/archdischild-2018-315412. [Epub ahead of print] Review. PMID: 30425110
2017
Kuzniewicz MW, Puopolo KM, Fischer A, Walsh EM, Li S, Newman TB, Kipnis P, Escobar GJ. A Quantitative, Risk-Based Approach to the Management of Neonatal Early-Onset Sepsis. JAMA Pediatr. 2017 Apr 1;171(4):365-371.
2014
Escobar GJ, Puopolo KM, Wi S, Turk BJ, Kuzniewicz MW, Walsh EM, Newman TB, Zupancic J, Lieberman E, Draper D. Stratification of risk of early-onset sepsis in newborns >=34 weeks' gestation. Pediatrics. 2014 Jan;133(1):30-6.
Mukhopadhyay S, Dukhovny D, Mao W, Eichenwald EC, Puopolo KM. 2010 Perinatal GBS Prevention Guideline and Resource Utilization. Pediatrics. 2014 Jan 20. [Epub ahead of print].
Little SE, Robinson JN, Puopolo KM, Mukhopadhyay S, Wilkins-Haug LE, Acker DA, Zera CA. The effect of obstetric practice change to reduce early term delivery on perinatal outcome. J Perinatol. 2014 Jan 9.[Epub ahead of print]
Newman TB, Draper D, Puopolo KM, Wi,S, Escobar GJ. Combining Immature and Total Neutrophil Counts to Predict Early Onset Sepsis in Term and Late Preterm Newborns: Use of the I/T2. Pediatric Infectious Diseases Journal, accepted for publication, 2014.
Puopolo KM and Escobar GJ. Neonatal Sepsis. In Workbook in Practical Neonatology, 5th edition, 2014. Eds. Polin RA and Yoder MC.
2013
Mukhopadhyay S, Eichenwald EC, Puopolo KM. Neonatal early-onset sepsis evaluations among well-appearing infants: projected impact of changes in CDC GBS guidelines. J Perinatol. 2013 33(3):198-205.
Cape A, Tuomala RE, Taylor C, Puopolo KM. Peripartum Bacteremia in the Era of Group B Streptococcus Prophylaxis. Obstet Gynecol. 2013 121(4):812-818.
Klinzing DC, Ishmael N, Dunning Hotopp JC, Tettelin H, Shields KR, Madoff LC, Puopolo KM. The Two-Component Response Regulator LiaR Regulates Cell Wall Stress Responses, Pili Expression and Virulence in Group B Streptococcus. Microbiology. 2013 Jul;159(Pt 7):1521-34.
Puopolo KM and Escobar GJ. Early-Onset Sepsis: A Predictive Model Based on Maternal Risk Factors. Curr Opin Pediatr. 2013 25(2):161-166.